Lipid droplet
CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation
... elevated lipid droplet ...and lipid metabolism in hepatocytes and contribute to clarifying the function of this gene in the context of metabolic ...
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YC-1 induces lipid droplet formation in RAW 264.7 macrophages
... on lipid droplet accumulation and foam cell formation in ...of lipid droplets in a murine macrophage cell line, RAW ...intracellular lipid droplets in ...of lipid droplets and the mean ...
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Cytoplasmic activated protein kinase Akt regulates lipid droplet accumulation in Drosophila nurse cells
... dramatic lipid-droplet phenotype in nurse cells? In mammals, Akt can promote the transcription of genes involved in lipid biosynthesis and storage pathways (Eberle et ...altered lipid ...
5
Uridine prevents tamoxifen-induced liver lipid droplet accumulation
... tamoxifen-induced lipid accumulation in liver tissues made TAG and DAG to be readily available for PC ...intracellular lipid droplet accumulation, but not able to prevent other side effects ...
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Dynamics of the Lipid Droplet Proteome of the Oleaginous Yeast Rhodosporidium toruloides
... Ldp1 localized on LDs and promoted giant LD formation. Since Ldp1 has a putative perilipin domain (Pfam number PF03036) and it is a potential LD structural protein, we carried out experiments to verify its LD ...
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The effect of diet and exercise on lipid droplet dynamics in human muscle tissue
... muscle lipid droplet (LD) dynamics addressed in this ...Intramyocellular lipid (IMCL) storage occurs in LDs, which are considered to be highly dynamic organelles with an important role in regulating ...
12
Lipid droplet growth : regulation of a dynamic organelle
... complexes and interact with PA to promote slow LD fusion by the transfer of TAGs from small to large LDs. Phospholipid packing will increase in the shrinking LD and decrease in the expanding LD. Low affinity LD-proteins ...
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The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells
... of lipid droplets, can cause sequestration of palmitic acid into lipid ...between lipid droplet formation and the protection against palmitic acid induced lipotoxicity by unsaturated NEFAs in ...
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Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes
... LDs are far from inert vesicles, and are composed of a central core of neutral lipids surrounded by a phospho- lipid monolayer that occurs in close association with a complex array of proteins [6]. Crucial in the ...
8
Review Article Lipid droplet-associated proteins in alcoholic liver disease: a potential linkage with hepatocellular damage
... intracellular lipid droplets are coated with a phospholipid monolayer, on which many kinds of lipid droplet-associated proteins are ...in lipid metabolism in the physiological ...the ...
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Perilipins: a diversity of intracellular lipid droplet proteins
... minimize lipid– water interfaces. Accordingly, lipid droplet (LD) structures comprise a neutral lipid core surrounded by a monolayer of phospholipids and specialized LD-associated surface pro- ...
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RNA Interference Silencing of a Major Lipid Droplet Protein Affects Lipid Droplet Size in Chlamydomonas reinhardtii
... of lipid droplet-associated proteins in ...the lipid droplet fraction based on Coomassie bril- liant blue staining ...the lipid droplets failed because none of the tested constructs ...
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Dietary supplementation with soy isoflavones or replacement with soy proteins prevents hepatic lipid droplet accumulation and alters expression of genes involved in lipid metabolism in rats
... hepatic lipid droplet (HLD) is the hallmark pathology of non-alcoholic fatty liver disease ...HLD, lipid metabolism and related gene expression in ...
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Krahmer, Natalie (2011): Analysis of Lipid Droplet Proteins and their Contribution to Phospholipid Homeostasis during Lipid Droplet Expansion. Dissertation, LMU München: Fakultät für Biologie
... for lipid storage, such as mammalian adipose tissue or fly fat body react with rapid and dynamic changes in LD size and abundance to changes in nutrient intake and energy ...saturated lipid storage capacity ...
122
Lipases and lipid droplet-associated protein expression in subcutaneous white adipose tissue of cachectic patients with cancer
... Studies of lipid metabolism in cachexia have generally focused on later stages of the disorder when severe loss of adipose tissue has already occurred. Therefore, we also studied adipose tissue in the Walker-256 ...
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Rotaviruses Associate with Cellular Lipid Droplet Components To Replicate in Viroplasms, and Compounds Disrupting or Blocking Lipid Droplets Inhibit Viroplasm Formation and Viral Replication
... Rotaviruses are a major cause of acute gastroenteritis in children worldwide. Early stages of rotavirus assembly in infected cells occur in viroplasms. Confocal microscopy demonstrated that viroplasms associate with ...
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Toxoplasma gondii skeletal muscle cells interaction increases lipid droplet biogenesis and positively modulates the production of IL 12, IFN g and PGE2
... of lipid precur- sors from host cytoplasm and efficiently manufactures them into complex lipids to its own benefit [4,37,38], we hypothesized a role for LD biogenesis during ...
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Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
... reduces lipid droplet turnover and thereby activates mTOR-S6K signaling, inhibits E3 ligase RNF168 expression and RNF168- mediated 53BP1 protein ubiquitination in re- sponse to ...
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Kaeuferle, Theresa (2015): Identification of microRNAs regulating adipocyte differentiation via mTOR nutrient-signaling. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... influence lipid droplet deposition, but revealed an attenuating effect on adipocyte differentiation as evidenced by its influence on adipocyte/pre-adipocyte marker gene expression at late stages of ...and ...
83
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro
... of lipid droplet numbers after 3 days (25% increase in oil-red O staining, P = ...large lipid droplets in vehicle-treated cells, but greater numbers of small lipid droplets in ...
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