Lipid droplet (LD)
Suppressive actions of eicosapentaenoic acid on lipid droplet formation in 3T3-L1 adipocytes
... phospho- lipid monolayer that occurs in close association with a complex array of proteins ...a lipid droplet scaffold protein ...on LD size, however, alterations in ATGL activity profoundly ...
8
The effect of diet and exercise on lipid droplet dynamics in human muscle tissue
... muscle lipid droplet (LD) dynamics addressed in this ...Intramyocellular lipid (IMCL) storage occurs in LDs, which are considered to be highly dynamic organelles with an important role in ...
12
Dynamics of the Lipid Droplet Proteome of the Oleaginous Yeast Rhodosporidium toruloides
... potential LD structural protein, we carried out experiments to verify its LD localization, to examine its cellular distribution, and more importantly, to determine whether it was a key player for giant ...
13
YC-1 induces lipid droplet formation in RAW 264.7 macrophages
... on lipid droplet accumulation and foam cell formation in ...of lipid droplets in a murine macrophage cell line, RAW ...intracellular lipid droplets in ...of lipid droplets and the mean ...
9
CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation
... and lipid droplet accumulation, as well as the modulation of tran- script levels in SPRY2 KO cells suggest that SPRY2 may be involved in metabolic homeostasis in hepatocytes, although whether this ...
11
The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells
... saline). Lipid droplet for- mation was analyzed by fluorescence microscopy and the area within the cells was quantified by the use of the Olympus xcellence software (Olympus, Hamburg, Germany) at 546 nm ...
11
Uridine prevents tamoxifen-induced liver lipid droplet accumulation
... tamoxifen-induced lipid accumulation in liver tissues made TAG and DAG to be readily available for PC ...intracellular lipid droplet accumulation, but not able to prevent other side effects ...
10
RNA Interference Silencing of a Major Lipid Droplet Protein Affects Lipid Droplet Size in Chlamydomonas reinhardtii
... membrane lipid and neutral lipid ...for lipid droplet formation and turnover. Lipid droplets in animal cells are surrounded by a monolayer of phospholipids, and the availability of ...
10
Review Article Lipid droplet-associated proteins in alcoholic liver disease: a potential linkage with hepatocellular damage
... intracellular lipid droplets are coated with a phospholipid monolayer, on which many kinds of lipid droplet-associated proteins are ...in lipid metabolism in the physiological ...the ...
10
Krahmer, Natalie (2011): Analysis of Lipid Droplet Proteins and their Contribution to Phospholipid Homeostasis during Lipid Droplet Expansion. Dissertation, LMU München: Fakultät für Biologie
... the LD surface (Guo et ...bilayer, LD binding proteins must contain special structural features in comparison to other membrane ...the LD monolayer because it would be energetically unfavourable if ...
122
Perilipins: a diversity of intracellular lipid droplet proteins
... Knockdown of PLIN3 using siRNA led to decreased TG levels in THP-1 macrophages. In addition, expres- sion of full length PLIN3 resulted in TG accumula- tion in THP-1 cells [60], and compensatory upregulation of PLIN3 was ...
11
Lipid droplet growth : regulation of a dynamic organelle
... the LD-ER contact, acting as a scaffolding protein recruiting PA-metabolism enzymes such as LIPIN1 and AGPAT2 [16, 17] as well as controlling PA levels by inhibiting GPAT ...facilitates LD fusion [19, 20] ...
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Chlamydomonas carries out fatty acid beta-oxidation in ancestral peroxisomes using a bona fide acyl-CoA oxidase
... understand lipid turnover processes in green microal- gae, we screened an insertional mutant library for strains perturbed in their capacity to remobilize oil ...the lipid droplet (LD) was ...
15
Dictyostelium Lipid Droplets Host Novel Proteins
... Next, we turned to two newly discovered proteins that do not have an obvious function in lipid metabolism. The protein en- coded by the DDB0184006 gene did not bear significant homolo- gies to any gene from other ...
13
Lipid droplets: FSP27 knockout enhances their sizzle
... unilocular lipid droplet structure within each white adipocyte (see the related article beginning on page ...of lipid droplets in white adipocytes from FSP27-KO mice caused both increased lipolysis ...
5
Fear vs Hope: Do Discrete Emotions Mediate Message Frame Effectiveness In Genetic Cancer Screening Appeals
... in lipid droplets. The study of lipid droplets in the scientific community now known as lipid droplet biology has, through genetic techniques, focused primarily on the various proteins located ...
69
A Novel Protein Kinase Localized to Lipid Droplets Is Required for Droplet Biogenesis in Trypanosomes
... in lipid homeostasis by increasing the number of lipid droplets ...induce lipid droplet biogenesis were still able to do so when LDK was ...of lipid, presumably yield- ing a ...
9
Pulsatilla koreana Nakai Downregulates C/EBPs/PPAR-gamma and Suppresses Fatty Acid Synthase via activation of AMPK-alpha in 3T3-L1 cells
... decreased lipid droplet accumulation, the expression of transcription factors, including CCAAT/enhancer-binding protein α, β, δ, peroxisome proliferator-activated receptor gamma and mRNA levels of fatty ...
7
miR-25 modulates triacylglycerol and lipid accumulation in goat mammary epithelial cells by repressing PGC-1beta
... Results: Using a highly sensitive method of S-poly(T) plus for miRNAs detection, we analyze the expression patterns of 715 miRNAs in goat mammary gland tissues at different stages of lactation. We observed that miR-25 ...
10
Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
... regulates lipid droplet turnover [12], we examined whether G0S2-mediated radioresistance is related with G0S2 lipolytic inhibitor ...promote lipid droplet formation ...that lipid ...
13