Lipogenic enzymes
Synergism of thyroid hormone and high carbohydrate diet in the induction of lipogenic enzymes in the rat Mechanisms and implications
... of lipogenic enzymes in two rat tissues, liver, and ...diet. Enzymes studied included malic enzyme (ME), fatty acid synthetase, glucose-6-phosphate dehydrogenase, and 6-phosphogluconate ...four ...
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Effect of dietary fatty acids on expression of lipogenic enzymes and fatty acid profile in tissues of bulls
... To summarise, this study established that: (i) a long-term feeding regime with n-3 fatty acids supplementation results in an accumulation of these health-beneficial fatty acids in cattle muscle; (ii) ACC, SCD and D6d ...
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Increased serum levels of lipogenic enzymes in patients with severe liver steatosis
... FAS and LPL are central enzymes of lipid metabolism. FAS is believed to be a major determinant of the max- imal hepatic capacity to generate fatty acids by de novo lipogenesis [5]. Over-expression of FAS has been ...
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Effect of Passive Immunization with Specific Anti-FSH on Tes- ticular Lipids and Some Lipogenic Enzymes of Adult Bonnet Monkeys
... suggest an impaired lipogenesis in testes of bonnet monkeys. Malic enzyme which acts on malate, utilizing NADP as a cofactor to generate NADPH and NADP-isocitrate dehydrogenase also produces NADPH by the conversion of ...
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Biochemical Characterization for Lipid Synthesis in Aspergillus niger Ekhlass M. Taha | Hayyan I. Al-Taweil | Noura K.M.S | Wan Mohtar Wan Yusoff | |Othman Omar | Aidil Abdul Hamid
... the lipogenic enzymes –fatty acid synthase , ATP:Citrate lyase and malic enzyme as well as to NADPH-generating enzymes- glucose-6-phosphate dehydrogenase , 6- phosphogluconate dehydrogenase, and NAD- ...
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The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation
... We reasoned that, as an upstream regulator of key lipogenic enzymes, depletion of BRG1 should also increase the sensitivity of cells to fatty acid synthesis inhibitors. 5-tetradecyloxy-2-furoic acid (TOFA) ...
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Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1
... rate-limiting enzymes for the synthesis of fatty ac- ids, monounsaturated fatty acids, and cholesterol, respectively (16, 20, ...key lipogenic enzymes by quantitative ...these enzymes ...
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Lipogenic transcription factor ChREBP mediates fructose induced metabolic adaptations to prevent hepatotoxicity
... major lipogenic enzymes (fatty acid synthase [FASN], stearoyl-coenzyme A desaturase 1 [SCD1], and glucokinase [GCK]) were markedly induced by a HFrD, along with the induction of the lipogenic ...
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Feeding oxidized fat during pregnancy up-regulates expression of PPARα-responsive genes in the liver of rat fetuses
... oxidized fats are strong activators of peroxisome prolifer- ator-activated receptor α (PPARα) [1-3], a ligand-acti- vated transcription factor that belongs to the family of nuclear receptors. PPARα is centrally involved ...
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Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes
... controlling lipogenic enzymes, namely SREBP-1c, and genes coding lipogenic enzymes (FAS, phosphoenol pyru- vate carboxykinase (PEPCK), ATP citrate-lyase, pyruvate carboxylase) [25-27] has been ...
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Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice
... Results: After 3 weeks of feeding, the hepatomegaly and hepatic triglyceride accumulation were markedly alleviated in the lotus polyphenol-diet-fed db/db mice relative to the control mice. Although the lipolytic enzyme ...
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Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency
... Consistent with these findings, the expres- sion of lipogenic genes, Srebp1 , and Ppar γ , or lipolytic gene, Atgl , in the liver did not change significantly with BDE-47 treatment (Figu[r] ...
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Effect of different dietary oil sources on the growth performance, blood characteristics, fatty acid profiles, and expression of lipogenic genes in the liver of broiler chickens
... of enzymes is shared for the conversion of n-3 and n-6 fatty acids, a competition exists between the n-3 and n-6 fatty acid families for metabolism with an excess of one causing a significant decrease in the ...
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Oxidized eicosapentaenoic acids more potently reduce LXRα-induced cellular triacylglycerol via suppression of SREBP-1c, PGC-1β and GPA than its intact form
... First of all, we noticed that 4–16 h OEPA significantly decreased the T0901317-induced accumulation of TG in liver cells more than did intact EPA. In this experiment, 4 h OEPA was the most effective agent which was able ...
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SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1
... The transient changes in AT lipogenic capacity produced in ad-Insig1 mice result in changes in whole- body glucose and TG metabolism (Figure 2). The prevailing claim is that whole-body insulin sensitivity pos- ...
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E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis
... reveal that E2F1 plays an essential role in liver physiopathology through the regulation of glycolysis and lipogenesis. We demonstrate that E2F1 deficiency leads to a decrease in glycolysis and de novo synthesis of fatty ...
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Hypoxia induces a lipogenic cancer cell phenotype via HIF1α- dependent and -independent pathways
... hypoxic lipogenic phenotype was demonstrated to be the result of increased lipid scavenging activity in MDA-MB-468, HeLa and A549 cell lines, rather than an augmented lipogenesis [10, 25, ...
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Role for monokines in the metabolic effects of endotoxin Interferon gamma restores responsiveness of C3H/HeJ mice in vivo
... the lipogenic effects of endotoxin (LPS), we studied the effects of LPS and cytokines on hepatic fatty acid synthesis in LPS-sensitive C3H/OuJ mice and in LPS-resistant C3H/HeJ mice, whose macrophages are ...
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Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cells
... The results from 48 hour fatty acid analysis of FAO cells showed that at 48 hours the PL of cells treated with DPA contained both DPA and EPA. Therefore it was not clear if the results obtained in gene expression and ...
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1.5 Enzymes
... • Spiders and flies secrete an enzyme soup into or on their food. In spiders, this is injected into the prey's body. The enzymes digest the prey's body contents and the spider sucks up the resulting digested food. ...
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