Liquid Chromatography and Impurities
Determination and quantification of imiquimod and its related impurities from bulk drug production by high-performance liquid chromatography
... thin-layer chromatography (TLC) and ultra-performance liquid chromatography (UPLC) have been described for the determination of imiquimod and its ...four impurities in bulk ...high-performance ...
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DEVELOPMENT & VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS DETERMINATION OF IRBESARTAN AND ITS RELATED IMPURITIES IN PHARMACEUTICAL TABLETS
... development. Chromatographic impurity profiles are most often developed using reversed-phase high-performance liquid chromatography (RP-HPLC). The chromatographic impurity profile should allow detecting and ...
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Non chiral High Performance Liquid Chromatography method for monitoring unknown impurities generated during stability of Clopidogrel tablets
... performance liquid chromatography (HPLC) method for separating the unknown impurities generated during the accelerated stability storage of Clopidogrel Bisulphate ...unknown impurities in the ...
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Reversed phase liquid chromatography with mass detection and characterization of saxagliptin degradation related impurities
... performance liquid chromatography (HPLC) reveals a few selected methods for the determination of Saxagliptin either single or in combination with some other drugs like, metformin, ...degradation-related ...
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Method development and validation for determination and quantitative estimation of impurities in milnacipran hydrochloride by liquid chromatography technique
... organic impurities of the same, percentage and relative standard deviation of the results of organic impurities were calculated and results were compiled and results indicates the ruggedness of the ...
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An improved validated ultra high pressure liquid chromatography method for separation of Rotigotine impurities in Rotigotine Transdermal Patch
... HPLC system has been proved to be a promising tool for separation with shorter run time. Use of BEH C18 (100x2.6) mm, 1.7µ as stationary phase enabled optimization of UPLC for both peak selectivity and analysis speed. ...
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REVERSED PHASE LIQUID CHROMATOGRAPHY WITH MASS DETECTION AND NMR CHARACTERIZATION OF SITAGLIPTIN DEGRADATION RELATED IMPURITIES
... ABSTRACT: The current work on impurity profiling of Sitagliptin in its bulk drugs, included development of a stability- indicating reverse-phased liquid chromatographic method and its validation for the estimation ...
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Significance of various chromatographic techniques in herbal drug analysis
... hyphenated chromatography, are strongly recommended for the purpose of quality control of herbal medicines, since they might represent appropriately the “chemical integrities” of the herbal medicines and therefore ...
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ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY: A REVIEW
... their impurities in raw materials and final product testing is an essential ...high-resolution chromatography capable of reliably and reproducibly separating and detecting all of the known impurities ...
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Isolation and screening of lovastatin producing microorganisms
... layer chromatography and the estimation of lovastatin was calculated ...layer chromatography it was observed that, both commercial lovastatin and the sample spots had same Rf ...performance liquid ...
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IMPURITY PROFILE AND VALIDATION OF PHARMACEUTICAL (API) BULK DRUG
... three impurities were found during the analysis. High performance liquid chromatography method was developed and validated for the Impurities of albuterol in bulk and capsules dosage ...
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Isolation, Synthesis and Characterization of Novel Process Related Impurities in Cetirizine Dihydrochloride by Mass and NMR Spectrometry Laki P. Magar* 1,2 Bhaskar H. Zaware 1, Kishor More2 , Brajesh Sharma 2, Kailas Shikhare2 , Rajesh Kamath 2, Prashant Patil2 , Leena Gupta 2
... Cetirizine dihydrochloride batches were synthesized at manufacturing site of Ipca Laboratories Ltd. (Mumbai, India). HPLC grade acetonitrile and concentrated sulfuric acid was from Merck. Deuterated chloroform and D2O ...
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ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-A NEW REVOLUTION IN LIQUID CHROMATOGRAPHY
... Performance Liquid Chromatography (UPLC) can be regarded as a new direction for liquid ...of Liquid chromatography namely speed, resolution, and sensitivity of analysis by using ...
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“Chromatographic Analysis of Phytopharmaceuticals – A Review” by Aruna M. Garud, Varsha M. Jadhav, Vilasrao J. Kadam, India.
... Layer Chromatography (TLC), High Performance Thin Layer Chromatography (HPTLC), High Pressure Liquid Chromatography (HPLC), Gas Chromatography (GC) are used for the analysis of ...
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One-step ionic liquid-based ultrasound-assisted dispersive liquid–liquid microextraction coupled with high-performance liquid chromatography for the determination of pyrethroids in traditional Chinese medicine oral liquid preparations
... oral liquid preparations were investigated in this study. Simotang oral liquid (composed of Aucklandia lappa Decne, Citrus aurantium ...oral liquid (composed of Isatis indigotica Fort, Phragmites ...
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Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study
... thin-layer chromatography and HPLC-UV methods had been used to study the pharmacokinetics of saponins in PNS [5,6], the specific and more sensitive LC-MS/MS method allows for the simultaneous deter- mination of ...
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Dyed Fiber Analysis towards the Development of a LC-MS Comparative Finished Fiber Database for Forensic Purposes.
... TLC is used in forensic science for the analysis of dyes extracted from forensic fiber evidence when comparison microscopy and microspectrophotometry of the visible range are not able to discriminate between fibers of ...
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Determination of Glimepiride in Rat Serum by Rp Hplc Method
... performance liquid chromatography (RP-HPLC) method was de- veloped for the determination of glimepiride in rat ...step liquid-liquid extrac- tion with ...
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Biotransformation of ginsenosides Rb1, Rg3 and Rh2 in rat gastrointestinal tracts
... performance liquid chromatography; LC-MS: High performance liquid chromatography coupled with mass spectrometry; MS-MS: Tandem mass spectrometry; LC-MS-MS: High performance liquid ...
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Vol 3, No 3 (2014)
... Gas chromatography-ion trap mass spectrometry (GC-IT- MS) was employed for the investigation of the metabolite profile of the aqueous extract obtained from Dracaene draco ...
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