live attenuated
Temperature-Sensitive Live-Attenuated Canine Influenza Virus H3N8 Vaccine
... IMPORTANCE Two influenza A virus subtypes has been reported in dogs in the last 16 years: the canine influenza viruses (CIV) H3N8 and H3N2 of equine and avian ori- gins, respectively. To date, only inactivated influenza ...
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Live Attenuated Influenza Vaccine: Will the Phoenix Rise Again?
... It was found in a meta-analysis of 14 randomized controlled trials, 8 cohort studies, 1 case-control study, and 1 randomized controlled trial that live attenuated influenza vaccine– trivalent (LAIV3) had ...
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Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines
... a live attenuated vaccine approach based on mutation of coronavirus NSP16, a 2=O methyltransferase ...an attenuated strain sensitive to the activity of IFN-stimulated IFIT1 ...for live ...
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Live Attenuated Varicella Vaccine Use in Immunocompromised Children and Adults
... Live attenuated vanicella vaccine has been administered to 307 children with leukemia in remission.. Members of the NIAID Vanicella Vaccine Study Group: William Bonkowsky, MD, Philip LaR[r] ...
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Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines
... The live attenuated Candid#1 strain of JUNV has been shown to be an effective vaccine against AHF (22), but outside Argentina Candid#1 has only investigational new drug (IND) status, and studies addressing ...
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Genetically engineered live attenuated influenza A virus vaccine candidates.
... with live attenuated viruses, which can be admin- istered ...Such live vaccines induce an immune re- sponse which more closely mimics that raised after natural infection and theoretically should be ...
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Influenza Viruses with Rearranged Genomes as Live-Attenuated Vaccines
... of live-attenuated influenza virus vaccines (LAIV), there are safety concerns regarding the possibility of reassortment between the H5 gene segment and circulating influenza vi- ...
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Development of Live-Attenuated Arenavirus Vaccines Based on Codon Deoptimization
... of live-attenuated vaccine candidates offers several unique advantages over other current ...CD live-attenuated vaccine contains hundreds of silent mutations at the nucleotide level that would ...
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Development of a Mouse-Adapted Live Attenuated Influenza Virus That Permits In Vivo Analysis of Enhancements to the Safety of Live Attenuated Influenza Virus Vaccine
... The live attenuated influenza virus vaccine (LAIV) is preferentially recommended for use in persons 2 through 49 years of age but has not been approved for children under 2 or asthmatics due to safety ...
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Seasonal Effectiveness of Live Attenuated and Inactivated Influenza Vaccine
... Documented dates of vaccination, vaccine type, and lot numbers were obtained from provider records, electronic medical record, and registry data. If vaccine type could not be documented from these sources, we relied on ...
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Complexities in predicting the immunogenicity of live attenuated influenza vaccines
... We read with interest the findings from Matrajt et al.[1], who propose a novel approach to live attenuated influenza vaccine (LAIV) strain selection based on results from mathematical models. They suggest ...
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General Molecular Strategy for Development of Arenavirus Live-Attenuated Vaccines
... Because live-attenuated vaccines (LAV) induce robust cellular and humoral immune responses following a single immunization, they represent the most feasible approach to control LASV in West Africa and other ...
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Interaction between the nasal microbiota and S pneumoniae in the context of live attenuated influenza vaccine
... between live-attenuated in fl uenza vaccine (LAIV), successive pneumococcal challenge, and the healthy adult nasal microbiota and mucosal immunity using an experimental human challenge ...
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Alternative Strategy for a Quadrivalent Live Attenuated Influenza Virus Vaccine
... Vaccines against seasonal influenza viruses are manufactured to confer protection against circulating IAV and IBV strains. Current vaccines rely primarily on antibody re- sponses to the virus’ hemagglutinin (HA) surface ...
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Description and characterization of a novel live attenuated tri segmented Machupo virus in Guinea pigs
... Background: Machupo virus (MACV) is a member of the Mammarenavirus genus, Arenaviridae family and is the etiologic agent of Bolivian hemorrhagic fever, which causes small outbreaks or sporadic cases. Several other ...
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Live Attenuated Influenza Vaccine Enhances Colonization of Streptococcus pneumoniae and Staphylococcus aureus in Mice
... to live attenuated immunizations, and in particular, live attenuated influenza vaccines ...a live attenuated viral vaccine can directly modulate colonizing dynamics of important ...
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Immunization of Children With Acute Lymphoblastic Leukemia With Live Attenuated Varicella Vaccine Without Complete Suspension of Chemotherapy
... A multicenter trial of live attenuated vanicella vaccine in children with leukemia in remission. Manufacturer’s Production and Safety Testing Syllabus[r] ...
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Type III Interferon Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection In Vivo
... to live attenuated virus, tight control of YFV-17D replication by the host is likely still required to attenuate virulence and prevent evasion of the immune response while adaptive immunity is being ...even ...
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Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines
... vaccines. Live attenuated influenza vaccines with modified NS1 or lacking the entire NS1 coding region have been extensively explored and evaluated in two previous human trials (22, 28, ...fully ...
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An Oral Live Attenuated Vaccine Strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (2019-nCoV)
... oral live attenuated vaccine can be beneficial in SARS-Cov-2 infection because the attenuated virus initially infects the gut, stimulates the mucosa associated immune system sparing the respiratory ...
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