Liver X receptors
Liver X receptors regulate adrenal cholesterol balance
... the liver X receptors (LXRa and LXRb) in preventing accumulation of free cholesterol in mouse adrenal glands by controlling expression of genes involved in all aspects of cholesterol utilization, ...
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Liver X Receptors Suppress Activity of Cholesterol and Fatty Acid Synthesis Pathways To Oppose Gammaherpesvirus Replication
... replication. Liver X receptors (LXRs) are transcription factors that are critical regulators of cellular fatty acid and cholesterol synthesis ...
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Liver X receptors as integrators of metabolic and inflammatory signaling
... The liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that are activated ...
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Coordinate regulation of neutrophil homeostasis by liver X receptors in mice
... indeterminate. Liver X receptors (LXRs) are members of the nuclear receptor superfamily that regulate both lipid metabolic and inflammatory gene ...
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Cholestenoic acids regulate motor neuron survival via liver X receptors
... ferent cranial nerves examined (loci III, IV, V, VII, and X; Figure 3, A and B). These effects were specific, as 7αH,3O-CA, which is not an LXR ligand, failed to regulate islet-1–GFP expression (Fig- ure 3B). ...
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Les “Liver X receptors” (LXRs) et le métabolisme lipidique dans l’épididyme murin
... Puisque les LXRs sont connus pour reguler I'expression de srebplc et de fas, codant respectivement pour la <<sterol response element binding protein >> et la &l[r] ...
11
Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
... adrenal glands, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ is ubiquitously expressed (26). The ligand- activated transcription factors form obligate heterodimers with the retinoid X ...
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Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation
... nuclear receptors were strongly associated with AP1 transcriptional regulators, with PPARG displaying an early preference for AP1 motifs and co-occupancy, while LXRs exhibited a more pronounced late associ- ation ...
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Liver X receptors α and β regulate renin expression in vivo
... The renin-angiotensin-aldosterone system controls blood pressure and salt-volume homeostasis. Renin, which is the first enzymatic step of the cascade, is critically regulated at the transcriptional level. In the pres- ...
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Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans
... Liver X receptor (LXR) alpha (NR1H3) and beta (NR1H2) can influence macrophage biology by modula- tion of lipid metabolism and by effects on innate immu- ...
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Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases
... proprotein convertase subtilisin/kexin type 9 (PCSK9) (Zhang et al., 2012). When cellular cholesterol levels rise, oxysterols are formed and serve as ligands for LXRs (Janowski et al., 1999). Activated LXRs induce IDOL ...
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Liver X receptor opens a new gateway to StAR and to steroid hormones
... Liver X receptors (LXRs) broadly limit cholesterol accumulation by regu- lating expression of genes involved in cholesterol efflux and storage. In this issue of the JCI, Cummins et al. report that ...
5
Original Article D-4F alleviates renal lipid abnormalities and increases the protein levels of renal LXRβ in LDL receptor-null mice fed a western diet
... Abstract: Objectives: Lipid abnormalities appear to contribute to both the initiation and progression of renal injury, regardless of etiology. D-4F contains a class A amphipathic helix with a polar face and a nonpolar ...
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Liver X Receptor: A novel therapeutic target
... The liver X receptors α and β are orphan nuclear receptors that are key regulators in maintaining cholesterol ...the liver X receptors also functions in lipid and ...
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Endothelin action in rat liver Receptors, free Ca2+ oscillations, and activation of glycogenolysis
... High affinity binding sites for endothelin (ET) were identified on rat liver plasma membranes. Binding of 125I-ET-1 with its site was specific, saturable, and time dependent (kobs = 0.019 +/- 0.001 min-1), but ...
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Retinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cells.
... nuclear receptors that belong to the steroid/thyroid hormone receptor ...retinoid receptors are grouped into two sub- families (retinoic acid [RA] receptors [RARs] and retinoid X ...
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4. Endocrine physiology (Part 4).pptx
... receptor also stimulate gluconeogenesis , by activation of α receptors on the liver cells and increase muscle glycogenolysis which increase plasma lactate levels:. Also epinephrine [r] ...
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Effect of specific dietary constituents on coronary heart disease risk factors
... the liver is a major deposition site for ...insulin receptors activity/number in the liver which increased the heaptic insulin clearance, and possibly led to a reduced SNS activity and hence lower ...
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Characterization of the hepatitis B virus EnhI enhancer and X promoter complex.
... Since the 2c site is essential for the liverspecific activity of the basal enhancer module, the reduction of X promoter activity in liver cells is likely due to loss of the liver-specifi[r] ...
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The role of the liver X receptor in chronic obstructive pulmonary disease
... Methods: We investigated LXR gene and protein expression levels in alveolar macrophages and whole lung tissue from COPD patients and controls, the effect of LXR activation on the suppres[r] ...
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