low-dose-combination therapy
Exploiting Autoimmunity Unleashed by an Off-Label Low-Dose Immune Checkpoint Blockade to Treat Advanced Cancer
... cancer therapy by blockade of co-inhibitory ...is dose-dependent. While the combination of two immune checkpoint inhibitors (ICIs) increased efficacy, the incidence of severe adverse events was also ...
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Combined low-dose LiCl and LY294002 for the treatment of osteoporosis in ovariectomized rats
... the low-dose combination therapy was superior to the individual administration of LiCl or LY294002 and whether it could exert an anti-osteoporotic effect by promoting bone formation and ...
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... is dose dependent. High dose (40-80 mg) of statin therapy showed significant increase in blood glucose parameters after 6 months of therapy whereas, low dose is associated with ...
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Case Report Sustained complete remission of a limited-stage blastic plasmacytoid dendritic cell neoplasm followed by a simultaneous combination of low-dose DeVIC therapy and radiation therapy: a case report and review of the literature
... of low-dose DeVIC therapy and LRT and sustained a complete ...regimen low-dose DeVIC therapy and LRT appeared to be a well- tolerated useful method of treatment for limit- ...
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Fixed combination of lercanidipine and enalapril in the management of hypertension: focus on patient preference and adherence
... a combination, both drugs can be given in lower dosage, thus minimizing the risk of side effects compared with full-dose ...fixed low-dose combinations are available, allowing two agents to be ...
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Combination therapy with low-dose teriparatide and zoledronate contributes to fracture healing on rat femoral fracture model
... of low-dose rhPTH (1 – 34; 10 μ g/kg) in a rat femoral fracture model, in which treatment increased callus bone mineral content (BMC) and bone density, as well as dynamic strength and was thus found to be ...
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Similar short term clinical response to high dose versus low dose methotrexate in monotherapy and combination therapy in patients with rheumatoid arthritis
... in dose was allowed (e.g. step-up MTX dose or step-down prednisone dose) but no change in medication type was allowed between initial treatment and the follow- up visit after 3–6 ...MTX dose ...
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Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single centre study
... conclusion, low-dose infliximab treatment leads to decreased neoangiogenesis and deactivation of the endothelium, resulting in decreased cell infiltration and clinical improvement in psoriasis and psoriatic ...
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Fixed dose combination therapy for the prevention of atherosclerotic cardiovascular diseases
... and low- to middle-income countries (Lonn 2010; Yusuf 2011) and may not meet with patient ...fixed-dose combination therapy is expected to be better than with multiple tablets, but it has been ...
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Case Report A case of secondary plasma cell leukemia resistant to novel agents, in which stringent complete remission was achieved and maintained for a long period of time after VAD therapy and tandem autologous transplantation
... a low- er degree of efficacy aga- inst PCL than against ...in combination with vincristine-doxorubicin- dexamethasone (VAD) therapy and autologous peripheral blood stem cell transplantation (Au- ...
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Combination therapy with rituximab, low-dose cyclophosphamide, and prednisone for idiopathic membranous nephropathy: a case series
... In an attempt to more effectively induce remission while allowing for a reduced exposure to high-dose glu- cocorticoids, the practice pattern in our group for the treatment of newly diagnosed, relapsing, and ...
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Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis
... demographic data and present medications were recorded; a complete history was taken; and a physical examination and routine laboratory examinations, including whole blood counts, tests of renal and hepatic function, and ...
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Aclidinium bromide/formoterol fixed-dose combination therapy for COPD: the evidence to date
... formoterol combination on isolated human bronchial ...the combination model indicated a synergistic action at the low doses of aclidinium and formoterol in inducing smooth muscle relaxation in ...
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Real-world medication persistence and outcomes associated with basal insulin and glucagon-like peptide 1 receptor agonist free-dose combination therapy in patients with type 2 diabetes in the US
... Generalized linear regression models with appropri- ate data transformation and data distribution were used to evaluate the impact of persistence vs nonpersistence with basal insulin and GLP-1 RA combination ...
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Gastric Cancer Immunotherapy: An Overview
... by low levels of pro-inflammatory TNF-α, IL-1, IL-12, and interferon gamma (IFN-γ) but markedly ele- vated levels of anti-inflammatory IL-6, IL-10, and IL-1 ...
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Vol 24, No 2 (2014)
... the combination in old world ...in combination with 20 mg/kg of allopurinol, while other trials have mostly used a higher dose of meglumine ...effective dose of antimony in combination ...
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Efficacy of Ezetimibe/Simvastatin (10/10 mg) Versus High Dose Statin in Dyslipidemia Patients: A Meta-analysis of Randomized Controlled Trials
... (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), high sensitivity C-reactive protein (hs-CRP), triglyceride (TG), and non-high-density lipoprotein cholesterol (non- ...
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Adherence to treatment with artemether–lumefantrine or amodiaquine–artesunate for uncomplicated malaria in children in Sierra Leone: a randomized trial
... This study also identified specific characteristics which may impact adherence to AL and AQAS. AL was less likely to be taken correctly at one site, but was better tol- erated than AQAS at both sites. The complexity of ...
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Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial
... Previous trials on low dose primaquine’s transmission- reducing properties have assessed efficacy based on gam- etocyte carriage [10]. However, the non-linear relationship between gametocyte levels and ...
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aime201701030-m160570.pdf
... One placebo-controlled trial of tenoxicam (40 mg once daily) showed that it reduces pain but is no differ- ent from placebo for swelling in patients with acute gout. High-quality evidence from 1 RCT (38) and ob- ...
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