low-dose methotrexate
Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis
... with methotrexate, the drug has been well tolerated, although toxicities were encoun- ...which low- dose methotrexate causes clinically significant liver fi- brosis has been debated but does ...
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Adverse Effects of Low-Dose Methotrexate in Patients with Rheumatoid Arthritis
... of low-dose methotrexate in adult patients of Kashmir valley fulfilling the revised American College of Rheumatology ...recommend methotrexate in all patients of rheumatoid ...on ...
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Low-Dose Methotrexate Inhibits Methionine S-Adenosyltransferase In Vitro and In Vivo
... received methotrexate regimens that reflected low-dose clinical use in ...to methotrexate. Methotrexate but not fo- late depletion suppressed MAT genes, proteins and activity in ...
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Oral events related to low-dose methotrexate in rheumatoid arthritis patients
... Descriptors: Methotrexate; Arthritis, rheumatoid; Oral manifestations; ...and low-dose methotrexate (MTX) is used extensively as a second line therapy in the treatment of ...taking low ...
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Single Low-Dose Methotrexate-Induced Fatal Pancytopenia: Case Report and Review of the Literature
... Adult Hematology Clinic, Medicana International Samsun Hospital, Turkey *Corresponding author: Burak Uz, Yenimahalle Mahallesi, Şehit Mesut Birinci Caddesi, No: 85, 55080, Canik/Samsun, Turkey DOI: ...
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Low-dose methotrexate was first demonstrated to be a. Understanding the Mechanisms of Action of Methotrexate
... of methotrexate on acute ...of methotrexate on chronic ...of methotrexate on adjuvant arthritis of ...with methotrexate treatment ...discontinued methotrexate treat- ment, while the ...
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Low-dose methotrexate in myeloproliferative neoplasm models
... methotrexate is not causing myelosuppression, with the marrow being able to increase erythropoiesis and mount an appropriate reticulocyte response. Intriguingly, we also observed slight increases in pSTAT5 and ...
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A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity
... for low-dose meth- otrexate toxicity were studied in 28 ...of low-dose metho- trexate toxicity seen in ...trend methotrexate levels until the level is ...to low-dose ...
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The Effects of Low Dose Methotrexate on Metabolism in Primary Human PBMCs
... Introduction Methotrexate has been shown to be both a cytotoxic and anti-proliferative drug- at both high and low ...that low-dose MTX has no cytotoxic effect in unactivated primary cells and ...
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Pulmonary function in patients with trophoblastic disease treated with low-dose methotrexate
... This report describes our findings in 16 consecutive patients with low-risk persistent trophoblastic disease who required treatment with methotrexate between February 1994 and August 199[r] ...
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Low dose Methotrexate Therapy for Intravenous Immunoglobulin resistant Kawasaki Disease
... vasculitic syndrome of unknown etiology, occurring primarily in children younger than 5 years of age. In 15% to 25% of children with untreated KD, coronary artery aneurysms or ectasia develop, which can lead to ...
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In vitro inhibition of HUVECs by low dose methotrexate – insights into oral adverse events
... 8. Sokka T: Increases in use of methotrexate since the 1980s. Clin Exp Rheumatol 2010, 28(61):S13 – 20. Epub 2010 Oct 28. 9. Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, Moreland LW, O ‘ Dell ...
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Serosal complications of single-agent low-dose methotrexate used in gestational trophoblastic diseases: first reported case of methotrexate-induced peritonitis
... Summary Methotrexate (MTX) is a folate antagonist widely used both as an anticancer drug and as an ...8-day methotrexate and folinic acid regime may be associated with pleuritic chest pain and ...with ...
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QUANTITATIVE LIVER FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH LOW-DOSE METHOTREXATE: A LONGITUDINAL STUDY
... a low GEC or ABT at baseline seemed not to be risk factors for further declines during MTX therapy in view of negative correlations between annual change in quantitative liver function and baseline value for both ...
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Low-risk persistent gestational trophoblastic disease treated with low-dose methotrexate: efficacy, acute and long-term effects
... patients had only mild side effects. Three patients had a rash, two had mild liver function changes and three had thrombo- cytopenia. Vomiting occurred in 57%. Treatment courses were shorter and less costly in hospital ...
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Similar short term clinical response to high dose versus low dose methotrexate in monotherapy and combination therapy in patients with rheumatoid arthritis
... MTX dose with or without other csDMARD or glucocorticoids does not result in better clinical efficacy after 3–6 months compared to a low ...a low MTX dose may induce delays in suppression of ...
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Similar short-term clinical response to high-dose versus low-dose methotrexate in monotherapy and combination therapy in patients with rheumatoid arthritis
... MTX dose with or without other csDMARD or glucocorticoids does not result in better clinical efficacy after 3–6 months compared to a low ...a low MTX dose may induce delays in suppression of ...
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Low-dose methotrexate in sickle-cell disease: a pilot study with rationale borrowed from rheumatoid arthritis
... developed low blood platelet counts: grade 1 (Patient #5: 91,000/μl) and grade 4 (Patient #10: 24,000/μl and #13: 11,000/μl) attributable to hydroxyurea that returned to normal levels in a few days after ...
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Clinical Outcomes of Low-Dose Methotrexate Therapy as a Second-Line Drug for Intravenous Immunoglobulin-Resistant Kawasaki Disease
... Nevertheless, none of the patients enrolled in this study showed the common side effects of MTX, such as leukopenia, hepato- toxicity, and ulcerative stomatitis. 29 The most serious complication of KD is CAL, and we have ...
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Clinical Outcomes of Low Dose Methotrexate Therapy as a Second Line Drug for Intravenous Immunoglobulin Resistant Kawasaki Disease
... Nevertheless, none of the patients enrolled in this study showed the common side effects of MTX, such as leukopenia, hepato- toxicity, and ulcerative stomatitis. 29 The most serious complication of KD is CAL, and we have ...
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