lung tumorigenesis
NLRP3 deletion inhibits inflammation-driven mouse lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide
... NLRP3 deletion significantly suppressed the tumor incidence, mean tumor count and tumor size of visible tumors on the surface of lungs induced by B(a)p or B(a)p plus LPS, implying NLRP3 inflammasome may be involved in ...
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Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D driven lung tumorigenesis
... 3 lung cancer cell lines harboring the same codon 12 Kras mutation and found that siRNA-based Sag knockdown caused in general accumulation of (a) pIκBα to inac- tivate NF-κB, which is required for Kras-mediated ...
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O GlcNAcylation is required for mutant KRAS induced lung tumorigenesis
... Alteration of cellular metabolism has been shown to be import- ant for survival and progression of established cancer cells (42). It is likely that metabolic byproducts reinforce the cancer phenotype by modulating not ...
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KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling
... cell lung cancer (NSCLC), which is the leading cause of cancer deaths worldwide, remains largely ...in lung tumorigenesis and metastasis, suggesting that KDM2A may be a promising therapeutic target ...
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Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis
... human lung adenocarcinomas, we found that compound-heterozygous deletion of Dok2 and Dusp4 in mice resulted in lung tumorigenesis with short latency and high incidence, and that their co-deletion ...
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Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis
... human lung adenocarcinomas, we found that compound-heterozygous deletion of Dok2 and Dusp4 in mice resulted in lung tumorigenesis with short latency and high incidence, and that their co-deletion ...
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MicroRNA 31 initiates lung tumorigenesis and promotes mutant KRAS driven lung cancer
... during tumorigenesis in several types of can- cer, including breast, ovarian, prostate, bladder, hepatocellu- lar, and gastric carcinoma and melanoma ...small-cell lung, and esophageal squamous cell ...
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Elevated expression of STIM1 is involved in lung tumorigenesis
... transforming growth factor β (TGF-β) signaling pathway [35, 36]. Zhang et al. reported that TGIF participated in the regulation of Wnt/β-catenin signaling pathway [37]. Our published paper revealed that the increased ...
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Wnt/β catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
... in lung cancer is ...mouse lung does not itself promote tumor ...in lung epithelium to produce a more aggressive tumor phenotype by imposing an embryonic distal progenitor phenotype and by decreasing ...
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Presenilin Mutation Suppresses Lung Tumorigenesis via Inhibition of Peroxiredoxin 6 Activity and Expression
... squamous lung cancer, but decreased in mutant presenilin 2 (PS2) containing AD ...carcinogen-induced lung tumor development compared to wildtype transgenic ...suppress lung tumor development by ...
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Arsenic, asbestos and radon: emerging players in lung tumorigenesis
... In lung epithelial cells, asbestos-induced glutathione de- pletion results in phosphorylation and activation of EGFR, overexpression of different AP-1 proto-onco- genes, and AP-1 transactivation ...
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HIF2α cooperates with RAS to promote lung tumorigenesis in mice
... HIF2α-producing lung tumors are poorly differentiated, with focal squamous differentiation, and display increased invasiveness. Histologi- cal examination of tumors from 40-week-old LSL-Kras mice, as expected, ...
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overexpression in transgenic mice and amelioration of tumor formation by miR-16
... Angiogenesis is one of the crucial causes of cancer development, and vascular endothelial growth factor (VEGF) overexpression is associated with poor prognosis in patients with non-small cell lung cancer (NSCLC). ...
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Original Article The expression of actate dehydrogenase A (ADA) in NSCLC stem cells (SC) affects tumor progression and metastasis
... Lung cancer is the most prevalent and deadly malignant tumor worldwide, and about 85% of lung cancer cases belong to non-small-cell lung carcinoma (NSCLC) [1]. With the progression of medical science ...
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Original Article A detrimental mutation on USP40 unlocks the tumorigenesis in a rare case of lung cancer
... Abstract: Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung ...in lung cancer, with the parallel existence of multiple subclones characterized by their own specific mutational ...
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A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer
... in tumorigenesis of NSCLC, we transplanted USP9X- or TTK-depleted A549 cells into the right flank region of nude mice, and observed greatly suppressed tumor growth in nude mice with A549 cells expressing lower ...
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Blood and lung microRNAs as biomarkers of pulmonary tumorigenesis in cigarette smoke-exposed mice
... the lung fragment undergoing miRNA analysis were subjected, as blind samples, to lung ...the lung and blood serum of all mice, we aimed at validating the detection of circulating miRNAs as a ...
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ABCC4 is required for cell proliferation and tumorigenesis in non-small cell lung cancer
... in lung cancer cell lines were measured by real- time polymerase chain reaction and Western blot, ...cell lung cancer patients were detected by real-time polymerase chain ...
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<p>DUB3 Facilitates Growth and Inhibits Apoptosis Through Enhancing Expression of EZH2 in Oral Squamous Cell Carcinoma</p>
... It has been demonstrated that DUB3 is overexpressed in many cancer, involving in non-small cell lung cancer. 13 In this present study, the tumor and normal tissues were obtained from 50 con fi rmed OSCC patients. ...
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DACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis
... cell lung cancer; OD: Optical densities; OS: Overall survival; PBS: Phosphate buffered solution; PMSF: Phenylmethanesulfonyl fluoride; PRX3: Peroxiredoxin 3; PVDF: Polyvinylidene fluoride; RFS: Relapsed-free ...
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