LXR agonist
Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells
... non-steroidal LXR agonist N-(2,2,2-trifluoro- ethyl)-N-[4-(2,2,2-tri-fluoro-1-hydroxy-1-trifluorom- ethyl-ethyl)-phenyl]-benzene sulfonamide (T0901317) was purchased from Sigma (Saint Louis, ...
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The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models
... by LXR deacti- ...with LXR antagonist GSK2033. LXR agonist T0901317 was added for ...that LXR deactivation re- sulted in a lipid composition with increased overall chain lengths and ...
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LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL
... of LXR agonist in mice revealed a slight but non-significant role of LXR in the regulation of apoE in vivo ...than LXR would regulate hepatic apoE gene in mice and probably in humans, ...
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Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment
... Next we examined if the T0-mediated up-regulation of ABCA1 and apolipoproteins had an effect on the level of insoluble Aβ. T0 was administered to 6-month old APP23 mice (n = 5), 5 times per week for 4 weeks at a daily ...
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Liver X Receptor Regulates Rheumatoid Arthritis Fibroblast-like Synoviocyte Invasiveness, Matrix Metalloproteinase 2 Activation, Interleukin-6 and CXCL10
... The LXR agonist significantly reduced FLS ...synthetic LXR agonist T0901317 significantly reduced the number of in- vading DA FLS in a dose-dependent manner by 64% (1 μ mol/L) and 99% (10 μ ...
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LXR promotes the maximal egress of monocyte derived cells from mouse aortic plaques during atherosclerosis regression
... that LXR agonist treatment increased Ccr7 mRNA ...Moreover, LXR agonist treatment of primary human immature DCs resulted in functionally significant upregulation of ...that LXR is ...
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LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target
... of LXR diminishes pathogenic phenotypes associated with ...the LXR agonist GW3965, supplemented in a low-fat diet (LFD + GW), for 5 ...of LXR target genes, Abca1 and Srebp1c, in RPE-choroid ...
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Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain
... full agonist for both LXRα and LXRβ isoforms, which can readily cross the blood-brain barrier to exert its specific actions in brain, exerted an antinociceptive effect in rat joint pain and diabetes-caused thermal ...
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Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2
... of LXR activation on inflammatory gene expression. However, LXR- dependent repression of inflammatory genes has been reported in multiple cell types including astrocytes [37] and therefore would have been ...
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The Role of the Liver X Receptor (LXR) in the Fetal Programming of Hepatic Gluconeogenesis
... of LXR was not altered by neonatal GW3965 treatment, it is still conceivable that LXR activity itself is enhanced ...of LXR to its target ...neonatal LXR agonist treatment. For example, ...
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Intervention in hepatic lipid metabolism : implications for atherosclerosis progression and regression
... For the study on LDLr –/– mice, male homozygous LDL receptor-deficient mice (LDLr –/– ; C57BL/6 background) of 12 weeks old were used. The animals were fed with semi-synthetic Western-type diet (WTD) containing 15% (w/w) ...
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Selective inhibition of liver X receptor α-mediated lipogenesis in primary hepatocytes by licochalcone A
... HepG2 cells were plated into 24-well plates 24 h prior to transfection and grown in DMEM supplemented with 10% charcoal-stripped FBS. Transfections were performed with Gal4-TK-luciferase, Gal4-hLXRα ligand binding domain ...
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ER phospholipid composition modulates lipogenesis during feeding and in obesity
... lowing LXR agonist treatment compared with mice transduced with shRNA adenoviral control (Figure ...to LXR agonism, strongly sug- gesting that LPCAT3 activity is mechanistically linked to SREBP- 1c ...
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Liver X receptor activation induces apoptosis of melanoma cell through caspase pathway
... [4]. LXR agonists have been shown to be effective in treating cardiovascular diseases, metabolic syndromes, and murine models of atherosclerosis, diabetes and Alzheimer’ s disease ...that LXR agonists ...
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A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
... (LXRα) agonist, Abcg5/stero- lin-1 and Abcg8/sterolin-2 appeared to be expressed at the apical ...a LXR agonist, had higher Abcg8 mRNA expression and tended to secrete more biliary cholesterol than ...
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Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
... by LXR activation in Th17 cells (Supplemental Figure 3), while LXR agonists treatment promoted Srebp-1 binding onto the Il17 promoter at the same region (Fig- ure ...without LXR agonist ...
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Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription
... synthetic LXR ligand T0901317 compound on the induction of wild-type Srebp-1c promoter linked to a luciferase reporter in the absence or presence of AMPK activa- tors AICAR and ...the LXR ligand T0901317 ...
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Medicinally active dihalocyclopropanes
... Tamoxifen is a ligand for the ER with an affinity in the nanomolar range. 34 Tamoxifen belongs to a class of molecules called Selective Estrogen Receptor Modulators (SERMs). The characteristic of SERM compounds is that ...
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p38 Mitogen-Activated Protein Kinase and Liver X Receptor-α Mediate the Leptin Effect on Sterol Regulatory Element Binding Protein-1c Expression in Hepatic Stellate Cells
... and LXR binding sites were required for leptin inhibition of SREBP-1c promoter activity (see Fig- ure ...that LXR plays a central role in insulin- mediated activation of SREBP-1c tran- scription in liver ...
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A Machine Learning Approach for the Discovery of
... structure for most of the full agonist trajectory, whereas in the inverse agonist bound trajectories these 440. residues are in a more disordered conformation[r] ...
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