Lysine-specific demethylase
Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma
... with Lysine-specific demethylase 1 (LSD1) [18, ...catalyzes lysine demethylation in a flavin adenine dinucleotide (FAD)-dependent oxidative reaction [20, ...from lysine 4 (H3K4) [20] ...
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Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines
... Background: Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and ...
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Original Article Over-expression of lysine-specific demethylase 1 predicts tumor progression and poor prognosis in human esophageal cancer
... as lysine-specific demethylase 1 (LSD1) and his- tone deacetylase 2 (HDAC2), are involved in the initiation and progression of many human can- cers ...
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Lysine-specific demethylase 1 promotes tumorigenesis and predicts prognosis in gallbladder cancer
... Gallbladder Cancer (GBC), characterized by invasive growth and infiltrative dissemination, is difficult to diagnose and has poor prognosis. Emerging evidence demonstrates that Lysine-Specific ...
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Original Article Epigenetic modulation by lysine-specific demethylase 1 induces gastric cancer metastasis
... that lysine-specific demethylase 1 (LSD1) functions as a pro-oncogene and exerts vital roles in cancer cell proliferation and ...H3 lysine 4 (H3K4) ...
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Investigation of Histone Lysine-Specific Demethylase 5D (KDM5D) Isoform Expression in Prostate Cancer Cell Lines: a System Approach
... cancer. Lysine-specific demethylase 5D (KDM5D) is a male-specific histone demethylase that specifically demethylates di- and tri-methyl H3K4 at the start site of active ...
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The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2
... Several lysine methyltransferases (KMTs) and lysine demethylases (KDMs) are involved in H3K36 methylation ...example, lysine-specific demethylase 2A (KDM2A) (also named JHDM1A) can ...
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Engagement of the Lysine-Specific Demethylase/HDAC1/CoREST/REST Complex by Herpes Simplex Virus 1
... Among the early events in herpes simplex virus 1 replication are localization of ICP0 in ND10 bodies and accumulation of viral DNA-protein complexes in structures abutting ND10. ICP0 degrades components of ND10 and ...
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NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect
... Previous studies showed that the expression of LSD1 positively correlates with the malignancy of various organs [13-17]. The members of the amine oxidase family also impair the activity of LSD1. However, many of these ...
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Lysine specific demethylase 1 mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
... H3K9 demethylation may mediate IL-1β-induced mPGES-1 expression through several nonexclusive mecha- nisms. H3K9 demethylation may promote transcriptional activation by enhancing lysine acetylation and allowing ...
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Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer
... histone demethylase which represses and activates transcription by specifically demethylating the methyl groups from mono- and di-methylated Lysine (Lys)4 of histone H3K4me and Lys9 of H3K9me ...
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The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent
... histone demethylase, KDM1A, is a lysine-specific demethylase (also known as LSD1, KIAA061, and AOF2) shown to be required for global DNA methylation in ES cells ...
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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
... histone demethylase, lysine-specific demethylase 1 (LSD1) in 2004 [43], challenged this notion and proved lysine methylation is dynamically ...
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H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming
... H3 lysine 9 tri- and di-methylation (H3K9me3/2), but the intrinsic reason for this remains ...H3K9 demethylase genes, lysine-specific demethylase 4D (KDM4D) and 4E (KDM4E), are related ...
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Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the heam-containing pigment from oxyhaemoglobin
... Oxidation of oxyHb which is brought about by cells of P. gingivalis is inhibited by gingipain inhibitors N-ethylmaleimide and tosyl-Lys-chloromethane [3], suggesting that either cell-associated Lys- and/or ...
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Identification of glucocorticoid inducible cytochromes P 450 in the intestinal mucosa of rats and man
... We used monoclonal antibodies and complementary DNAs (cDNAs) to glucocorticoid- inducible liver cytochromes P-450 in rats (P-450p) and in man (HLp) to search for related cytochromes in intestinal mucosa. In rat ...
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Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C
... We focused the next phases of our downstream analysis on the three top candidate genes FBXL5, SCMH1 and CACYBP with the highest delta Z scores (Table 1). Inter- estingly, the three top CpG sites identified by methyla- ...
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Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic ribosomal DNA condensation
... Set2-engaged active structure accessible to RNA polymer- ase I. During mitosis, however, nucleolar silencing is likely to be primarily regulated by Jhd2, a histone H3K4 demethylase, in a Net1- or Sir2-independent ...
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Genome-wide identification and expression analysis of DNA demethylase family in cotton
... DNA demethylase gene plays an important role in regulating gene ...DNA demethylase gene responded to cold, heat, drought and salt, abiotic stresses ...DML-like demethylase gene in ...DML3 ...
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Expanding the zebrafish genetic code through site specific introduction of azido lysine, bicyclononyne lysine, and diazirine lysine
... of lysine derivatives, including a photo-cleavable amino acid, into zebrafish proteins ...other lysine derivatives not used previously in zebrafish to further expand the tool kit for use in ...
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