lysine-specific demethylase 1
Original Article Over-expression of lysine-specific demethylase 1 predicts tumor progression and poor prognosis in human esophageal cancer
... Abstract: Lysine specific demethylase 1 (LSD1), the first characterized histone demethylase, roles importantly in epigenetic regulation of carcinogenesis and cancer ...
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Lysine-specific demethylase 1 promotes tumorigenesis and predicts prognosis in gallbladder cancer
... Gallbladder Cancer (GBC), characterized by invasive growth and infiltrative dissemination, is difficult to diagnose and has poor prognosis. Emerging evidence demonstrates that Lysine-Specific ...
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Original Article Epigenetic modulation by lysine-specific demethylase 1 induces gastric cancer metastasis
... Lysine-specific demethylase 1 (LSD1, also na- med KDM1A) was identified as the first histo- ne demethylase that demethylates histone H3- K4 and H3K9, and represses gene transcrip- tion ...
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Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines
... Background: Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in ...
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Lysine specific demethylase 1 mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
... interleukin 1 β -induced histone H3 lysine 9 demethylation and microsomal prostaglandin E synthase 1 protein ...for 1 hour prior to stimulation with 100 pg/ml interleukin 1 β ...
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NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect
... the protein expression level of LSD1 was not changed after NCL1 treatment (Fig. 1A). To determine whether LSD1 inhibition influences gene specific methylation status, LNCaP cells treated with NCL1 were subjected ...
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Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer
... The immunohistochemistry (IHC) for LSD1 (1:100; Cell Signaling Inc., Danvers, MA, USA) was performed on formalin-fixed, paraffin-embedded tissue sections using steam heatinduced epitope retrieval and the DAB ...
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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
... histone demethylase, lysine-specific demethylase 1 (LSD1) in 2004 [43], challenged this notion and proved lysine methylation is dynamically ...
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Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma
... with Lysine-specific demethylase 1 (LSD1) [18, ...catalyzes lysine demethylation in a flavin adenine dinucleotide (FAD)-dependent oxidative reaction [20, ...from lysine 4 (H3K4) ...
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Engagement of the Lysine-Specific Demethylase/HDAC1/CoREST/REST Complex by Herpes Simplex Virus 1
... virus 1 replication are localization of ICP0 in ND10 bodies and accumulation of viral DNA-protein complexes in structures abutting ...the lysine-specific demethylase 1 ...
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Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance
... the demethylase activity of KDM5A (for example [25–29]), there are currently no specific inhibitors shown to target KDM5A without inhibiting other members of the KDM5 ...KDM5A demethylase activity in ...
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KDM1A microenvironment, its oncogenic potential, and therapeutic significance
... KDM1A: lysine‑specific histone demethylase 1A; AOL: amine oxidase‑like domain; SWIRM: Swi3p/Rsc8p/Moira domain/ small alpha helical domain; DNMT1: DNA methyltransferase 1; CoREST: ...
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The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2
... and can thus induce the expression of COX-2 [9, 10]. To explore the effect of the related transcription factors on COX-2 re-expression during TPA treatment, H719 cells were treated with TPA at 100 ng/mL for up to 6 hrs ...
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The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent
... Protein 1), DNMTs are directed to methylated histone ...histone demethylase, KDM1A, is a lysine-specific demethylase (also known as LSD1, KIAA061, and AOF2) shown to be required for ...
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Investigation of Histone Lysine-Specific Demethylase 5D (KDM5D) Isoform Expression in Prostate Cancer Cell Lines: a System Approach
... Figure 1 shows multiple transcript variants encoding three different isoforms. KDM5D isoform transcripts are found to be predominantly expressed in all male tissues. Most tissues, except spleen, exhibit ...
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Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1
... tissues. As shown in Figure 1A, fifty percent (101/202) of tumor tissues exhibited high expression of KDM2A with strong nuclear staining and light cytoplasmic staining. Clinicopathological association study demonstrated ...
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Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C
... and 1 (completely methy- lated) representing the ratio of combined locus ...Sex specific DNA methylation analysis in brain was performed using published dataset (GEO Accession No: GSE15745) ...
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Expanding the zebrafish genetic code through site specific introduction of azido lysine, bicyclononyne lysine, and diazirine lysine
... developments are needed to make this method useful in a large number of biological studies. First, we were unable to carry out photo-crosslinking under conditions in which we successfully carried out photo-crosslinking ...
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Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic ribosomal DNA condensation
... with 1:250 dilutions of anti-DIG mouse monoclonal IgG, luorescein isothiocyanate (FITC)-conju- gated goat anti-mouse IgG and FITC-conjugated donkey anti-goat ...file 1: Figure S3A, a total of 400, 280 and ...
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Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the heam-containing pigment from oxyhaemoglobin
... the HRgpA-oxyHb incubation. To test whether metHb formation in the presence of the R-gingipain was proteolytically mediated, oxyHb was incubated with HRgpA in the presence of the specific R-gingipain protease ...
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