lysophosphatidic acid
Activation of fibroblast like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid lysophosphatidic acid receptor 1 cascade
... of lysophosphatidic acid receptor 1 on the expression of adhesion molecules on fibroblast-like ...a lysophosphatidic acid (LPA) receptor 1 inhibitor (LA-01; 0, 1 or 10 nM) for 30 minutes, then ...
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Clinical evaluation on the determination of plasma lysophosphatidic acid concentration in Chinese human pancreatic cancer
... Aims: Observing the alteration of plasma Lysophosphatidic acid (LPA) concentration in patients with pancreatic cancer and evaluating its clinical potential for diagnosis. Methods: We examined the plasma LPA ...
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Regulation of the pulmonary vasculature by lysophospholipase D autotaxin - lysophosphatidic acid signaling
... 109. Tager AM, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z, Polosukhin V, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD. The lysophosphatidic acid receptor ...
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<p>Inhibitors of the Autotaxin-Lysophosphatidic Acid Axis and Their Potential in the Treatment of Interstitial Lung Disease: Current Perspectives</p>
... properties. Lysophosphatidic acid (LPA) is a member of the PLGF family that promotes a diverse range of physiological cellular functions by binding to speci fi c G-protein-coupled receptors (LPAR 1 – 6), ...
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Increased triacylglycerol production in oleaginous microalga Neochloris oleoabundans by overexpression of plastidial lysophosphatidic acid acyltransferase
... pathway, lysophosphatidic acid acyltransferase (LPAAT or LPAT; EC ...of lysophosphatidic acid to generate a key intermediate, phosphatidic acid ...
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Original Article Differential expression of lysophosphatidic acid receptors between benign and malignant tissues in humans
... with lysophosphatidic acid (LPA) and malignant asci- tes, both LPAR1 and LPAR2 are activated, their migration is induced by activated LPAR1, but inhibited by activated LPAR2 ...
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Plasma levels of lysophosphatidic acid in ovarian cancer versus controls: a meta-analysis
... (“lysophosphatidic acid” or “MOPA” or “LPA” or “1-oleoyl-lysophosphatidic acid” or “monooleyl- phosphatidate” or “1-O-oleyllysophosphatidic acid”) and (“ovarian neoplasms” or “ovary ...
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Lysophosphatidic acid plasma concentrations in healthy subjects: circadian rhythm and associations with demographic, anthropometric and biochemical parameters
... Background: Lysophosphatidic acid (LPA) is a bioactive lipid with a wide biological ...uric acid and negatively with estimated glomerular filtration rate and serum ...
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Over expression of lysophosphatidic acid receptor 2 in human invasive ductal carcinoma
... Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3- phosphate), the simplest glycerophospholipid, mediates a broad range of cellular responses including smooth muscle cell contraction, platelet ...
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The lysophosphatidic acid (LPA) and sphingosine 1 phosphate (S1P) receptor gene families: cloning and comparative expression analysis in Xenopus laevis
... and lysophosphatidic acid (LPA) are endogenous bioactive lipids which mediate a variety of biological cell responses such as cell proliferation, migration, differentiation and ...
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Autocrine lysophosphatidic acid signaling activates β catenin and promotes lung allograft fibrosis
... Tissue fibrosis is the primary cause of long-term graft failure after organ transplantation. In lung allografts, progressive terminal airway fibrosis leads to an irreversible decline in lung function termed bronchiolitis ...
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Serum induced changes in the physiology of mammalian retinal glial cells: role of lysophosphatidic acid
... that their role in K¤ redistribution has been particularly well studied (Newman, 1995). By a specialized mechanism of K¤ spatial buffering, termed K¤ siphoning (Newman, Frambach & Odette, 1994), K¤ enters a Muller ...
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Lysophosphatidic acid–induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4
... Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycerol-3-phosphate) is a bioactive lipid mediator that regulates cell migration, prolifera- tion, morphological change, and the production of cytokines (1, ...
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Lysophosphatidic Acid Inhibits Bacterial Endotoxin-Induced Pro-Inflammatory Response: Potential Anti-Inflammatory Signaling Pathways
... Previous studies have demonstrated that heterotrimeric guanine nucleotide-binding regulatory (Gi) protein-deficient mice ex- hibit augmented inflammatory responses to lipopolysaccharide (LPS). These findings suggest that ...
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Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3 kinase signaling pathway
... Lysophosphatidic acid (LPA) is the smallest and structur- ally simplest of all the glycerophospholipids. It occurs nor- mally in serum and binds with high affinity to albumin, while retaining its biological ...
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Lysophosphatidic acid signalling in development
... Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes ...
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The autotaxin-lysophosphatidic acid–lysophosphatidic acid receptor cascade: proposal of a novel potential therapeutic target for treating glioblastoma multiforme
... Glioblastoma multiforme (GBM) is the most highly ma- lignant type of brain tumor. Despite the use of optimal treatments and an evolving standard of care (maximal safe resection with concurrent temozolomide (TMZ) ...
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Endogenous lysophosphatidic acid (LPA1) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts
... Lysophosphatidic acid (1-acyl-2-hydroxy-sn-glycero-3-phosphate; LPA) belongs to a family of endogenous lipid molecules involved in a number of cellular processes including proliferation, apoptosis and ...
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Effect of lysophosphatidic acid on the follicular development and the expression of lysophosphatidic acid receptor genes during in vitro culture of mouse ovary
... Lysophosphatidic acid (LPA) known as a serum-derived growth factor, is involved in several cell physiological functions in the female reproductive system including: oocyte maturation, in vitro fertilization ...
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Theoretical study of lysophosphatidic acid acyltransferase 2 inhibitors
... AGPAT2, 1-acylglycerol-3-phosphate-o-acyltransferase2 (also known as lysophosphatidic acid acyltransferase, is a novel target for cancer therapy. There are several lysophosphatidic acid ...
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