lysyl-oxidase
Purification procedure and assay for the activity of lysyl oxidase
... Lysyl oxidase purification from rodents tissues extracts involved negative adsorption based on the principle where the enzyme molecules in incubation mixture cannot bind to the adsorbent and stay in so- ...
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Non-linear optical microscopy and histological analysis of collagen, elastin and lysyl oxidase expression in breast capsular contracture
... Fig. 3 Histological and NLO microscopy images of capsule with Baker grade 4 (example 1). a An overview of a capsule biopsy with Baker grade 4 stained with hematoxylin and eosin (H&E) with representative magnified ...
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Lysyl oxidase-like 1 polymorphisms in a southwestern Greek cataract population with pseudoexfoliation syndrome
... have been associated with development and heredity of PEX syndrome. The most important evidence for genetic causes is the identification of single nucleotide polymorphisms (SNPs) in the lysyl oxidase-like 1 ...
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Original Article miR-200b is associated with reduced lysyl oxidase in cervical portion of uterosacral ligaments in women with pelvic organ prolapse
... a Lysyl Oxidase Activity Assay Kit (Fluorometric) (Abcam, Ca- mbridge, UK) under the guidance of the kit’s ...(lysyl oxidase standard and blank as positive and negative control) were added ...
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Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress
... is lysyl oxidase (LOX), a copper-binding amine oxidase that oxidizes lysine ε-amino groups in elastin and fibrillar collagens to aldehydes, which then spontaneously react to form covalent linkages ...
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Original Article Expression of lysyl oxidase (LOX) in human placental amnion in preterm labor
... of lysyl oxidase activity, the volume of reaction system per well in a 96-well plate was 100 μL including lysyl oxidase protein (50 μg), 10 mM cadaverine, reaction mix and assay ...inhibit ...
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Detecting quantitative trait loci affecting beef tenderness on bovine chromosome 7 near calpastatin and lysyl oxidase
... Abstract. From a study of 3 large half-sib families of cattle, we describe linkage between DNA polymorphisms on bovine chromosome 7 and meat tenderness. Quantitative trait loci (QTL) for Longissimus lumborum peak force ...
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Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution
... organization. Lysyl oxidase (LOX) activity, exerted by the LOX, LOXL1, LOXL2, LOXL3, and LOXL4 proteins [8], is one of the most important regulator of the ...
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Biological Chemistry The Core Promoter and Redox-sensitive Cis -elements as Key Targets for Inactivation of the Lysyl Oxidase Gene by Cadmium
... Lysyl oxidase (LOX), a copper-dependent enzyme, oxidizes peptidyl lysine residues in substrates, e.g., collagen, elastin and histone H1, essential for organization and stabilization of the extracellular ...
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Original Article Association between expression of lysyl oxidase and prognosis in solid tumor patients: a systematic review and meta-analysis
... Abstract: Background: Recently, lysyl oxidase (LOX) has been frequently reported to be overexpressed in various malignancies and to be involved in tumor invasion and migration. However, a prognostic role of ...
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Lysyl oxidase regulates transforming growth factor-[beta]1 function in bone
... Lysyl oxidase (LOX) is a copper-dependent amine oxidase that initiates the process of covalent intra- and intermolecular cross-linking in collagen and elastin ...
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Relationship between the content of lysyl oxidase dependent cross links in skin collagen, nonenzymatic glycosylation, and long term complications in type I diabetes mellitus
... Many abnormalities in collagen have been reported in insulin-dependent diabetes mellitus, some or all of which have been attributed to increased cross-linking. Although recent work has focused on the role of ...
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Clinical relevance of lysyl oxidase-like 2 and functional mechanisms in glioma
... prognosis. Lysyl oxidase-like 2 (LOXL2) is a kind of lysyl oxidase catalyzing the formation of peptidyl-lysine residues and promoting intramolecular cross-linking, especially for proteins in ...
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A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans
... Purpose: Lysyl oxidase (LOX) controls the cross-linking and maturation of elastin and collagen fibers. In this study, we investigated the association between LOX gene polymorphisms and intracranial aneurysm ...
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Original Article Lysyl oxidase G473A promotes migration, invasion and metastasis of ovarian cancer cells through regulating p38/Akt signaling pathways
... Ovarian cancer is one top leading cause of cancer related death and most ovarian can- cers were diagnosed in advanced stages fol- lowed by low overall survival rate [1]. The patho- genesis of ovarian cancer is identified ...
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Original Article Correlations of lysyl oxidase with MMP2/MMP9 expression and its prognostic value in non-small cell lung cancer
... Abstract: Lysyl oxidase (LOX) has been reported to regulate tumor metastasis and has been found to involve in modification of extracellular matrix (ECM) in the context of ...
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Association of Lysyl Oxidase (LOX) Gene Polymorphisms with Keratoconus Disease in Samples of Iraqi Patients
... the lysyl oxidase enzyme which catalyzes collagen crosslinking in cornea, therefore; one of the fundamental hallmark of KC disease is the lack of cross-links in stromal collagen this was combined with ...
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The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
... Europe PMC Funders Author Manuscripts Keywords lysyl oxidase; breast cancer; hypoxia; pre-metastatic niche; bone; osteoclast; secretome; proteomics Using a primary tumour hypoxic signatu[r] ...
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Lysyl oxidase activates cancer stromal cells and promotes gastric cancer progression: quantum dot-based identification of biomarkers in cancer stromal cells
... Purpose: Semiconductor quantum dots (QDs) are a promising alternative to organic fluorescent dyes for multiplexed molecular imaging of cancer stroma, which have great advantages in holistically analyzing the complex ...
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Abnormal copper metabolism and deficient lysyl oxidase activity in a heritable connective tissue disorder
... exostoses. Lysyl oxidase activity was low in the medium of cultured skin fibroblasts, this abnormality being accompanied by reduced conversion of the newly synthesized collagen into the soluble ...reduced ...
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