Macrocycle Conformational Flexibility in the FMO Complex
Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor
... achieving two specific aims. The first aim was to develop a highly reproducible crystallization method that enables determination of the high-resolution structure of DENV RdRp. The previous pro- tocol requires ...
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Flexibility and Conformational Entropy in Protein-Protein Binding
... components. Complex formation does not restrict the conformational free- dom of the partner proteins as a whole, but, rather, it leads to a redistribution of ...in conformational entropy for seven ...
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Conformational control of cofactors in nature The influence of protein induced macrocycle distortion on the biological function of tetrapyrroles
... Tetrapyrrole‐containing proteins are one of the most fundamental classes of enzymes in nature and it remains an open question to give a chemical rationale for the multitude of biological reactions that can be catalyzed ...
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Conformational Flexibility in the Immunoglobulin Like Domain of the Hepatitis C Virus Glycoprotein E2
... mation at the surface of both HCVpp and HCVcc. One of these conformations has been observed in complex with the human bnAb AR3C (10); insights into another one are provided by our crystal structure of MAb DAO5 in ...
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Ion mobility mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5
... the complex nature of the electric field used in TWIMS devices, the CCS of ions cannot be determined directly from mobility drift time values (t D ), and calibration was ...
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Proteolytic Processing of the Human Immunodeficiency Virus Envelope Glycoprotein Precursor Decreases Conformational Flexibility
... 51. Crooks ET, Tong T, Osawa K, Binley JM. 2011. Enzyme digests eliminate nonfunctional Env from HIV-1 particle surfaces, leaving native Env trim- ers intact and viral infectivity unaffected. J. Virol. 85:5825–5839. 52. ...
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Multimodal switching of a redox active macrocycle
... oxidation-induced conformational changes, photochemical switching and hemiquinhydrone ...hemiquinhydrone complex formation behavior respectively from none to single to ...
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Conformational Flexibility and the Interaction of Huperzine A in the Active Site of Acetylcholinesterase: A Quantum Chemical and Charge Density Study
... molecular conformational flexibility and the charge density distribution and the electrostatic properties of huperzine A in the active site, where the amino acids are interact with the huperzine A molecule ...
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Re(bpy)(CO)[subscript 3]CN as a Probe of Conformational Flexibility in a Photochemical Ribonucleotide Reductase
... volume of assay buffer in a second syringe to yield final concentrations of 45 μM. This baseline emission is shown by the black trace in Figure S2. As a second control pre-reduced α2 and Re-F-βC19 in one syringe were ...
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The conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability
... G94P complex, Arg92 rotates nearly 70 degrees and 8 Å to interact with residues Asp160 and Asp162 of the Asf1 C terminal ...mutant complex. Thus, the overall struc- ture of the Asf1-H3/H4 G94P ...
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Regional Conformational Flexibility Couples Substrate Specificity and Scissile Phosphate Diester Selectivity in Human Flap Endonuclease 1
... DNA complex in regions of the protein distal to the active site that were not observed at the same magnitude upon ad- dition of Ca 2+ to hFEN1. Several studies have shown that divalent metal ions and arch region ...
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Predicting sumoylation sites using support vector machines based on various sequence features, conformational flexibility and disorder
... Rapidly progressing research on sumoylation showed that sumoylation can alter the target ’ s localization, intra/ intermolecular interactions, and resulting roles in protein stability, protein-DNA binding activity, ...
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Contribution of bacteriochlorophyll conformation to the distribution of site energies in the FMO protein
... particular macrocycle conformation by qualitative comparison of the pigment conformations from different crystal ...of macrocycle distortions obtained from previous model compound and theoretical studies ...
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Study of protein-macrocycle Interactions for lessons in drug design
... 16 fragments that lead to experimentally validated hits (Evers and Klabunde, 2005). Because of their small size, doubts have been raised about the use of docking for fragments concerning the potential for binding mode ...
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Conformational flexibility of the pharmacologically important insulin analogues
... 4. DISCUSSION Since the discovery of insulin, a number of advances have been made to allow patients to mimic the normal pattern of insulin release more accurately and conven- iently. However, insulin therapy needs to ...
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Ring contraction in a dinuclear zinc(II) complex of a Robson macrocycle
... Herein we report the structure of the Zn II complex, (I), of this 18-membered macrocyclic product. The asymmetric unit of (I) consists of a molecule of the Zn complex, one ethanol solvent molecule, a ...
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On the flexibility of complex systems
... In conclusion, we have described the emergence of flexi- bility in a dense linear systems of equations of N real vari- able and M equations. This flexibility results from the appearance, for α < α c , of an ...
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Global Mapping of DNA Conformational Flexibility on Saccharomyces cerevisiae
... of flexibility peaks, suggesting that the flexible sequence may be derived by an expansion of canonical TAYRTA polyadenylation efficiency ...of flexibility in genomes and a strategy for its characterization ...
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Conformational Flexibility in Respiratory Syncytial Virus G Neutralizing Epitopes.
... Therapeutic monoclonal antibody treatment targeting respiratory syncytial virus (RSV) G protein 454. mediates viral clearance and reduces the pathogenesis of RSV infection in BALB/c mic[r] ...
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Distal Histidine Conformational Flexibility in Dehaloperoxidase from Amphitrite Ornata
... the conformational flexibility observed in the deoxy ferrous DHP that is obtain in a temperature of 100 ...H55 conformational flexibility may also be associated with the lack of a hydrogen ...
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