Macrophage foam cell
Differential inhibition of macrophage foam cell formation and atherosclerosis in mice by PPARα, β/δ, and γ
... and foam-cell ...same cell type, exemplified by the macrophage foam-cell, each receptor also regulates dis- tinct programs of gene ...
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CXCL5 limits macrophage foam cell formation in atherosclerosis
... of foam cells in both the brachiocephalic artery and the aortic root lesions (Figure 2B and Supplemental Figure 2E) corresponding to macrophages (Figure 2, C, E, G, and I, and Supplemental Figure 2C) with ...
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Computational systems biology of oxLDL induced macrophage foam cell formation A multilayer regulatory network analysis of atherogenic process
... Atherosclerosis, a chronic inflammatory disease of the vascular system, presents significant challenges to developing effective molecular diagnostics and novel therapies. A systems biology approach integrating data from ...
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Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation
... HC030031 decreased the efficacy of cholesterol efflux, thereby promoting macrophage foam cell formation. Moreover, AITC-activated TRPA1 prevented TNF- α -induced inflammation in macrophages. This ...
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Inhibitory effects of Mycoepoxydiene on macrophage foam cell formation and atherosclerosis in ApoE-deficient mice
... foam cell formation. It is thought that uptake of ox-LDL by macrophage scavenger receptors is largely responsible for disease ...as macrophage foam cell forma- tion and ...
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Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass
... The stimulating effect of apoA-I on apoE secretion from macrophages has been reported by several groups and also confirmed by us in the present study. We further investigated whether apoA-I also affects PLTP secretion ...
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Anti-atherosclerotic activity of n-Hexane extract of Eleutherine americana Merr. on human macrophage primary cell culture
... the macrophage foam cell at the subendothelial layer of the blood vessel ...human macrophage through in vitro induction with oxidized-Low Density Lipoprotein ...The macrophage was ...
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Chlamydia pneumoniae Accelerates Coronary Artery Disease Progression in Transgenic Hyperlipidemia-Genetic Hypertension Rat Model
... and cell cycle ...(25,26) cell types, which have been implicated in vulnerable plaque destabilization ...of cell survival (28), decreased IGF-bp2 would favor macrophage foam cell ...
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Loss of receptor mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
... attribute foam cell formation to scavenger receptor–mediated macrophage lipid uptake ...As foam cell formation has long been deemed critical to lesion development, the scavenger ...
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Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte generated reactive nitrogen species
... acid metabolism in vivo (42). In addition, functional roles for CD36 in processing apoptotic cells by den- dritic cells, differentiation of monocytes, accumulation of lipid in macrophages, fatty acid transport, and the ...
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Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation
... In these experiments, CLA was added after four days of culture, providing a model to investigate how CLA primes monocytes during their differentiation to macrophages. Therefore, this data suggests that treatment with the ...
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Cyclodextrins as catalysts for the removal of cholesterol from macrophage foam cells
... of cell cholesterol efflux ...stimulated cell cholesterol depletion, the combi- nation of the cyclodextrin shuttle together with the LUV sink produced a dramatic effect on cholesterol flux and net choles- ...
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Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI containing lipoproteins, so reducing the cholesterol efflux inducing ability of serum and aortic intimal fluid
... terol from the cells into the medium was measured (Fig. 2 A). With increasing amounts of serum, the rate of cholesterol ef- flux from the foam cells increased rapidly to a steady level at a serum protein ...
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Reactive oxygen species produced by macrophage derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro Implications for atherosclerotic plaque stability
... atheromatous foam cells when evaluated by scanning electron microscopy, oil red O, and nonspecific esterase staining ...of macrophage foam cells in granuloma or in aorta of hypercholesterolemic ...
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Original Article Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPARγ-ABCA1 pathway
... that foam cells were ...that foam cells induced by ox-LDL decreased after quercetin treatment (Figure ...and foam cell formation induced by ox-LDL in ...
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<p>Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages</p>
... The formation of macrophage foam cells is an important part of atherosclerosis. Based on the experiments described above, it was shown that isoborneol has an inhibitory effect on the accumulation of lipids ...
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Macrophage derived foam cells freshly isolated from rabbit atherosclerotic lesions degrade modified lipoproteins, promote oxidation of low density lipoproteins, and contain oxidation specific lipid protein adducts
... hypercholesterolemia. The MFC were isolated under sterile conditions using an enzymatic digestion procedure and discontinuous density gradient centrifugation. The purity of the MFC preparations was verified ...
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Lipoprotein lipase is synthesized by macrophage derived foam cells in human coronary atherosclerotic plaques
... particularly macrophage-derived foam cells, but was not detected in association with any intimal or medial smooth muscle ...with macrophage-derived foam cells, endothelial cells, adventitial ...
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Lowering the n-6/n-3 PUFAs ratio inhibits the formation of THP-1 macrophage-derived foam cell
... the foam cell ...of foam cells, which includes increasing of cholesterol uptake and biosyn- thesis, decreasing of cholesterol ...the foam cell, but not much is known about the effect of ...
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Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice
... Atherosclerosis is characterized by in fl ammation and choles- terol deposition in the arterial wall. Oxidation of LDL accompanies the disease process and oxidized lipoproteins are indeed present in vivo, particularly in ...
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