Macrophage/Monocyte
The monocyte-macrophage-mast cell axis in dengue pathogenesis
... Both innate and adaptive immune responses to DENV play significant roles in protection against DENV, but can also elicit pathological responses which may worsen disease [2, 7]. Understanding the mechanisms that regu- ...
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Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases
... Figure 2 Human MC and M ϕ differentiation, and distinct subset functions. Human CD14 ++ CD16 - classical MCs leave the bone marrow in a CC-chemokine receptor 2 (CCR2)-dependent manner. In the steady state, classical MCs ...
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Innate immunity and monocyte-macrophage activation in atherosclerosis
... of monocyte-macrophages infiltrating the plaque [12] and their location at plaque rupture-sensitive sites (such as the fibrous cap and areas of erosion [13,14]) is related to plaque ...[13]. Macrophage ...
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Molecular mechanisms of HIV 1 persistence in the monocyte macrophage lineage
... The introduction of HAART in 1996 has greatly improved survival, but it has been unable to eradicate the virus from latently infected reservoirs. A principle cause may be that besides the best characterized cellular ...
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Plasmodium falciparum PfEMP1 modulates monocyte/macrophage transcription factor activation and cytokine and chemokine responses
... IL-10, monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1 ␣ (MIP-1 ␣ ), MIP-1  , and TNF specifically in response to VAR2CSA PfEMP1-containing parasites than in response to ...
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Bordetella Adenylate Cyclase Toxin Inhibits Monocyte to Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte like Cells
... Preventing monocyte-to-macrophage transition at the site of infection is thus likely to play a role in the colonization capacity of ...differentiated macrophage cells can be dedifferentiated back to ...
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Original Article Increased circulating macrophage-colony stimulating factor and monocyte chemoattractant protein-1 are predictors of in-hospital events in Chinese patients with unstable angina pectoris
... Background: Macrophage colony stimulating factor (MCSF) and monocyte chemoattractant protein-1 (MCP-1) play an important role in the activation of monocyte resulting in the onset and progression of ...
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Hepatitis A Virus Suppresses Monocyte-to-Macrophage Maturation In Vitro
... To analyze the pathogenetic mechanism of hematopoietic dysregulation associated with hepatitis A virus (HAV) infections, we studied the influence of HAV on monocyte (MO)-to-macrophage (MAC) maturation in ...
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Regulation of HIV 1 transcription in cells of the monocyte macrophage lineage
... the monocyte-macrophage lineage, although replication occurs to a lesser extent than in infected T ...the monocyte-macrophage lineage become differentiated and activated and subsequently ...
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Epigenetic dynamics of monocyte-to-macrophage differentiation
... during monocyte-to-macrophage differentiation is a rapid, active process catalyzed by TET enzymes, as shown by increasing levels of 5hmC lev- els in the first 12 h of differentiation and the inhibition of ...
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Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis
... activated macrophages in the pathogenesis of SSc. Mac- rophages have been thought to be particularly activated in patients with skin disease including SSc and are poten- tially important sources for fibrosis-inducing ...
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Human cytomegalovirus infection of the monocyte/macrophage lineage in bone marrow.
... Because our data suggested that undifferentiated monocytes could be infected with HCMV in vitro, we asked whether endogenous HCMV DNA could be detected in bone marrow progenitor cells of[r] ...
5
Performance and immune characteristics of bronchoalveolar lavage by research bronchoscopy in pulmonary tuberculosis and other lung diseases in the Western Cape, South Africa
... decreased macrophage/monocyte frequencies, increased neutrophil frequencies and decreased lymphocyte frequencies in TB patients, relative to healthy and OLD control ...Furthermore, ...
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Oral contraceptives modify DNA methylation and monocyte-derived macrophage function
... Figure 3 Activation status of estrogen receptors. Representative western blot for estrogen receptor a phosphorylation (A) and representative western blot with corresponding densitometric analysis of estrogen receptor b ...
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Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma
... predominant macrophage cell population; however, under conditions of blood-brain barrier leakage, peripheral monocytes/macrophages can infiltrate the brain and participate in CNS disease ...peripheral ...
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Multidimensional assessment of alveolar T cells in critically ill patients
... (e.g., monocyte and macrophage populations and neutrophils) for transcriptional and epigenetic profiling, and the residual fluid can be used for pathogen isolation and sequencing and shotgun metagenomic ...
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Assessment of interactions of efavirenz solid drug nanoparticles with human immunological and haematological systems
... M-CSF: macrophage colony stimulating factor; MDM: monocyte derived macrophages; NK: natural killer; PAMAM: polyaminoamine; PBMC: peripheral blood mononuclear cells; PCC: physical–chemical characteristics; ...
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Impact of VIP and cAMP on the regulation of TNF α and IL 10 production: implications for rheumatoid arthritis
... induce monocyte, macrophage, and T-cell IL-10 but could, however, downregulate TNF-α upon stimulation and spon- taneous TNF-α production by ...augments macrophage IL-10 produc- tion with a ...
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Recent advances in the treatment of skin involvement in systemic sclerosis
... from monocyte-macrophage lineage cells, which also provide a precursor of pro- angiogenic hematopoietic cells and fibrocytes [21, ...the monocyte-macrophage lineage cells contrib- uting to ...
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Apoptosis of human intestinal epithelial cells after bacterial invasion
... mouse monocyte-macrophage cell lines following bacterial in- ...mouse monocyte- macrophage cell lines within 1–2 h of infection (17–19), although Shigella did not induce apoptosis of human ...
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