Macrophages/adipocytes
Interactive Changes between Macrophages and Adipocytes
... Pre- adipocytes accumulate less fat and have reduced gene expres- sion of adipogenic and lipogenic markers when the cells are induced to differentiate in the presence of a macrophage-con- ditioned medium ...of ...
9
Adipocyte/macrophage fatty acid–binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice
... particularly macrophages, in adipose tissue may be an important component of the develop- ment of adipose tissue inflammatory responses triggered by obe- sity and hence contribute to the metabolic consequences, ...
12
Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages
... Local PAF production by ATMs is the first element of AKG signaling. Macrophage-derived PAF is central to host defense (15, 75, 76). In the context of AT health, PAF was hence initially considered as a metabolically ...
16
Inflammation triggers specific microRNA profiles in human adipocytes and macrophages and in their supernatants
... M1 macrophages, as inferred from changes in the expression of well-recognized pro-inflammatory genes such as IL-6 and TNFα ...mature adipocytes upon inflam- mation (Table ...M1 macrophages was more ...
10
Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2–mediated and prostaglandin E2–mediated pathways
... 3T3-L1 adipocytes and RAW264.7 macrophages, we investigated the effects of butyrate on the release of PGE2 into the medium and on lipolysis in ...in macrophages and adipocytes, and butyrate ...
17
Original Article α-Naphthoflavone modulates inflammatory response in adipocytes-macrophages interaction through NF κB signaling
... during adipocytes differentiation and adipocyte-macrophage ...RAW264.7 macrophages. Conditioned medium from activated macrophages and α-NF pre-treated macrophage were used to investigate the effects ...
7
Effects of calcitriol on the crosstalk between macrophages and human adipocytes
... These results led to the postulation that calcitriol may act on transcription factors and activation pathways leading to proinflammatory gene expression. Thus the effect of calcitriol supplementation on the expression of ...
189
Adipocyte secreted exosomal microRNA 34a inhibits M2 macrophage polarization to promote obesity induced adipose inflammation
... mature adipocytes but exerts profound effects on ATMs, we next investigated whether it is secreted from adipocytes via exosomes, which can transport microRNAs to medi- ate intercellular communications ...
17
DGAT1 dependent triacylglycerol storage by macrophages protects mice from diet induced insulin resistance and inflammation
... both adipocytes and monocyte-derived macrophages and dendritic cells (34, ...yield adipocytes and a macrophage-containing stromal-vascular fraction ...WAT, adipocytes, and SVF by quantitative ...
13
Bone marrow–derived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in mice
... perilipin) adipocytes, which are supported by stromal vascu- lar tissue containing vascular endothelial cells and macrophages, and poorly characterized undifferentiated or stem cells containing adipoblasts, ...
13
Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
... vated macrophages in addi- tion to adipocytes, thereby influencing adipose tissue ...in adipocytes of AFasKO mice, whereas it was undetectable in macrophages (Figure 4D), consistent with ...
13
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis
... M2 macrophages are recruited to subcutane- ous WAT and secrete catecholamines to activate WAT browning (54, ...in macrophages exhibited severe impairment in cold-stimulated beige adipocyte ...
10
Regulation of vascular tone by adipocytes
... Adiponectin is mainly released by both brown [86] and white [69] adipocytes and is the most abundant adipo- kine in the circulation [87]. Adiponectin has been con- sidered an anti-inflammatory and antioxidative ...
12
Obesity induced inflammatory changes in adipose tissue
... Inflammation and mechanisms of type 2 diabetes: emerging questions Studies in the past decade left little doubt that inflammatory pathways are critical in the mechanisms under- lying insulin resistance and type 2 ...
5
TLR4 links innate immunity and fatty acid–induced insulin resistance
... in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue and macrophages is blunted in ...
12
The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes
... of adipocytes but do not translocate to the plasma membrane in response to ...3T3-L1 adipocytes were further fractionated in a self-forming iodixanol ...
7
Regulation of calcitonin gene-related peptide expression through the COX-2/mPGES-1/PGE2 pathway in the infrapatellar fat pad in knee osteoarthritis
... Methods: IFPs and STs were harvested from 138 KOA patients during total knee replacement (TKR) and analyzed for CGRP, cycloxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) expression using real- ...
6
Adipose morphology and metabolic disease
... smaller adipocytes (and a reduced number of adipocytes), suggesting that mTORC1 may promote adipocyte hypertrophy (Polak et ...in adipocytes develop lipodystrophy with age, suggesting that mTORC1 is ...
11
Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B
... PTP1B regulates Munc18c tyrosine phosphorylation The adipose tissue is a regulator of systemic glucose homeostasis and energy balance [27]. There are two major types of adipose tissues in mammals, white and brown. White ...
12
The generation of adipocytes by the neural crest
... of adipocytes and other mesenchymal cell types from ES cells (Dani et ...derive adipocytes from a highly enriched population of ES cell-derived neuroepithelial ...that adipocytes developing from ...
10