MAGE-A3
Original Article MAGE-A3 is highly expressed in a cancer stem cell-like side population of bladder cancer cells
... (MAGE- A3), one of the most studied cancer testis (CT) antigens, in these SP and main population (MP) cells derived from SW780 ...of MAGE-A3 and a positive coexpression of ...
8
Original Article Construction, expression and purification of recombinant HBcAg-MAGE-A3 therapeutic cancer vaccine
... at the amino terminus of HBcAg form a spike tip, the major immunodominant region (MIR), foreign epitopes could be inserted into MIR to generate a fusion peptide. This region was pre- viously reported to be the major B ...
6
Original Article Expression of MAGE-A3 and/or PRAME tumor antigens in South Korean gastric cancer patients
... of MAGE-A3 specific antibodies, IHC cannot distinguish MAGE-A3 from other members of the MAGE-A ...family. MAGE-A3 ex- pression was thus generally screened for us- ing ...
12
Original Article Rates of MAGE-A3 and PRAME expressing tumors in FFPE tissue specimens from bladder cancer patients: potential targets for antigen-specific cancer immunotherapeutics
... the MAGE-A3 and PRAME genes in bladder tumors and to investigate the feasibility of using formalin-fixed paraffin-embedded (FFPE) tumor tissues for ...of MAGE-A3 and PRAME using ...
11
Original Article Gene expression of MAGE-A3 and PRAME tumor antigens and EGFR mutational status in Chinese non-small cell lung cancer patients
... of MAGE-A3 and PRAME was determined by quantitative reverse transcription polymerase chain reaction (qRT- PCR) using TaqMan methods and the ABI PRISM 7900 Sequence Detection ...
12
Association of homogeneous inflamed gene signature with a better outcome in patients with metastatic melanoma treated with MAGE-A3 immunotherapeutic
... Tumour heterogeneity has been shown to be an important feature in different cancers; furthermore, it has been proposed to be a cause of treatment failure. 41–43 In this study, we found that the expression of ...
10
Adenovirus-mediated delivery of CALR and MAGE-A3 inhibits invasion and angiogenesis of glioblastoma cell line U87
... and MAGE-A3 genes were delivered to the glioblastoma cell line U87, using adenovirus ...and MAGE-A3 were detected by PCR and Western ...
10
Safety and immunogenicity of MAGE-A3 cancer immunotherapeutic with dacarbazine in patients with MAGE-A3-positive metastatic cutaneous melanoma: an open phase I/II study with a first assessment of a predictive gene signature
... with MAGE-A3-positive metastatic cutaneous melanoma, treat- ment with MAGE-A3 vaccination administered concur- rently with dacarbazine was generally well tolerated and induced ...
8
Original Article Predictive and prognostic effect of CD133 and cancer-testis antigens in stage Ib-IIIA non-small cell lung cancer
... showed MAGE-A3/4 and NY-ESO-1 positive staining in ...reasons. MAGE A10 expression is high in NSCLC, which may imply the possibility of its value in ...
10
Original Article Expression and clinical significance of cancer-testis genes in clear cell renal cell carcinoma
... Briefly, formalin-fixed paraffin-embedded tis- sue sections were deparaffinized in xylene, rehydrated through graded concentrations of ethanol to distilled water, and treated in hydro- gen peroxide for 10 min at room ...
8
Urine exosome gene expression of cancer-testis antigens for prediction of bladder carcinoma
... of MAGE-B4 was significantly higher in bladder cancer patients compared with normal samples (expression ...between MAGE-A3 and MAGE-B4 expressions in exosomes obtained from ...
9
Original Article Combined cancer testis antigens enhanced prediction accuracy for prognosis of patients with hepatocellular carcinoma
... 1991, MAGE-1 (melanoma associated antigen) gene has been cloned from melanoma cells [14], dozens of MAGE genes have been identified ...the MAGE proteins are termed as CTAs [16]. Many studies reported ...
16
Analysis of expression profiles of MAGE-A antigens in oral squamous cell carcinoma cell lines
... that MAGE-A antigens are simultaneously expressed in antigen groups. The MAGE-A subgroups differ in their protein ...of MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A6 and ...
9
Pommer, Björn (2008): Korrelation zwischen der Expression von MAGE-A Genen in disseminierten Tumorzellen und etablierten Prognosefaktoren bzw. dem Verlauf nach radikaler Prostatektomie beim lokal begrenzten Prostatakarzinom. Dissertation, LMU München: Medizinische Fakultät
... AAC-3' MAGE-A1 outer antisense 5'-CAG GAG CTG GGC AAT GAA GAC-3' MAGE-A1 inner sense 5'-TAG AGT TCG GCC GAA GGA AC-3' MAGE-A1 inner antisense 5'-CTG GGC AAT GAA GAC CCA CA-3' MAGE-A2 outer ...
52
Expression and prognostic significance of cancer-testis antigens (CTA) in intrahepatic cholagiocarcinoma
... MAGE-A1, MAGE-A3/4 and NY-ESO-1 have been applied for clinical trials of vaccine immunotherapy for multiple cancer patients, but the utility of CTA immunotherapy against patients with IHCC remains ...
6
Vaccines in Non Small Cell Lung Cancer
... Therapeutic vaccines for the treatment of NSCLC have been included in various clinical trials, hoping to obtain positive results in patients. Different mechanisms of ac- tion have been explored, including ...
6
Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapy
... from MAGE-A3 immunotherapy, while only 18% of the MITF-low proliferative classified tumors had clinical benefit from the vaccine ...for MAGE-A3 immunotherapy ...to MAGE-A3 ...
13
PubMedCentral-PMC4935975.pdf
... of MAGE-A4–RAD18 interac- tion, we show here that endogenous MAGE-A4 confers RAD18 stability and expression in cancer ...for MAGE-A4–RAD18 as a mutagenic driver or source of genomic instability in ...
14
I. NTRODUCTION MAGE matching rises frequently in the field of image
... MAGE matching rises frequently in the field of image analysis under many topics such as, image registration, template matching, image retrieval, image classification, etc. These methods are either feature-based ...
6
Health related quality of life improvement in chronic non-specific neck pain: secondary analysis from a single blinded, randomized clinical trial
... baseline); A3: Assessment at 3 months (A3 – 16 weeks from baseline); A3: Assessment just after the intervention period (3 weeks from baseline); A4: Assessment at 6 months (A4 – 30 weeks from ...
10