Mammary epithelial cell differentiation
Effect of substrate stiffness on early human embryonic stem cell differentiation
... stem cell differentiation was provided by qualitative studies involving mouse mammary epithelial cells that showed increased differentiation when grown on soft gel colla- gen substrates ...
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Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation
... some cell types, and in doing so it regulates the activity of RAC1 (Rosenberger and Kutsche, 2006; Sepulveda and Wu, ...controls epithelial polarity and ...
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CCAAT/Enhancer Binding Protein-delta (C/EBP-delta) regulates cell growth, migration and differentiation
... cancer cell lines ...HC11 cell lines approach contact mediated growth inhibition (48-72 hours), pSTAT3 and C/EBPδ protein levels increase and the levels of Cyclin D1, a marker of cell cycle ...
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Tif1γ is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition
... Transcriptional intermediary factor 1 (Tif1; also called ectodermin, Trim33, RFG7 or PTC7) has been recently implicated in the activities promoted by TGF superfamily pathways. Tif1 is a member of the TIF family of ...
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ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation
... the cell types of the mammary gland expressing ErbB3, confirming ErbB3 protein expression in developing alveoli (the milk-producing epithelial structures) ...to mammary glands from ErbB3 +/+ ...
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Differentiation of transformed and non-transformed human mammary luminal epithelial cells
... 5* day final cell numbers of the ErbB2 over-expressing lines, C3.6 (P<0.02) and C5.2. (P<0.02), but not of their non-transformed counterparts (HB4a, H4.1) or th[r] ...
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Murine amniotic fluid stem cells contribute mesenchymal but not epithelial components to reconstituted mammary ducts
... Mammary epithelial outgrowths can be observed in cleared mammary fat pads transplanted with ductal frag- ments or dispersed mammary ...identify mammary stem cells and to study their ...
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Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial mesenchymal transition
... mouse mammary gland epithelium induces tumors of multiple histological subtypes in a dose-dependent ...diverse differentiation, and exhibited progression to aggressive malignant neoplasms, as is often ...
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PubMedCentral-PMC4972522.pdf
... primary mammary epithelial cells (MECs) that express the receptor ...stem cell phenotype, activates MET signaling and enforces a differentiation ...predisposes mammary epithelial ...
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Tightly controlled MRTF A activity regulates epithelial differentiation during formation of mammary acini
... of mammary epithelial ...stem cell forma- tion and promotion of EMT ...deregulated cell cycle/apoptosis indicates a transforming potential of MRTF-A or MRTF-B in MCF10A ...
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A co culture genome wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation
... targeting cell cycle genes showed that the total count can be used as a surrogate for the GFP-positive ...in cell growth (adjusted P < ...-L9 cell growth using the Gene Functional Classification ...
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The WNT controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage
... stem cell self-renewal and quiescence, and promotes basal epithelial characteristics by regulating transcription of genes involved in cell proliferation, adhesion and the basal cytoskeleton, ...
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Stem Cell Research: A Novel Boulevard towards Improved Bovine Mastitis Management
... production. Mammary tissue damage reduces the number and activity of epithelial cells and consequently contributes to decreased milk ...Bovine mammary epithelial cells (MECs) and their stem ...
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Cytogenetic characterization and H-ras associated transformation of immortalized human mammary epithelial cells
... murine mammary tumors exhibited diverse histological ...the mammary gland, suggesting that constitutive mTERT expression led to the promotion of preneoplastic ...the cell cycle in cells with Rb ...
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Epithelial vimentin plays a functional role in mammary gland development
... for mammary gland ...in epithelial- to-mesenchymal transition (EMT) (Mendez et ...the mammary epithelium (Asiedu et ...of mammary gland ...mouse mammary ducts is significantly delayed ...
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A role for p53 in terminal epithelial cell differentiation
... and differentiation. For example, p53-induced differentiation is well documented in a number of cell lineages such as myogenic cells, osteogenic cells, ker- atinocytes, neurons, and thyroid cells (5, ...
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Bone morphogenetic proteins (BMPs) induce epithelial differentiation of NT2D1 human embryonal carcinoma cells
... germ cell tumours of adolescents and adults (TGCTs) are neoplasms thought to arise as a result of abnormal germ cell ...of differentiation into embryonic and extraembryonic ...stem cell ...
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Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias
... IRF1, polarity of the spheres is preserved and a lumen – albeit smaller – is maintained in most cases. Therefore, additional alterations are required to allow mammary tumor formation. These additional alterations ...
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Uptake of DNA by cancer cells without a transfection reagent
... different cell lines also revealed that those aggressive cancers have the ability to take large DNA, which supports the hypothesis that endocytosis is related to the aggressiveness of can- ...
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Epstein Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation Dependent Exit from the Cell Cycle
... normal epithelial cells into carcinomas, it is important to study latent EBV infection in non- transformed ...analogous epithelial cell transformation ...primary epithelial cells typically ...
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