Mammary Gland Development
Epigenomics of mammary gland development
... bertal mammary gland development, including a reduced number of TEBs, less side branching, and impaired ductal elongation [57, ...The mammary develop- mental defects in these mice are ...
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Keratin 6 is not essential for mammary gland development
... on mammary gland ...K6ab-null mammary tissues were transplanted into the cleared fat pads of host mice and allowed to grow for four ...in mammary gland ...of mammary epithe- lial ...
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Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity?
... for mammary stem cell self- renewal with unique developmental stage and time de- pendencies ...the mammary gland, localized Wnt signaling most likely plays a critical role in regulating the ...
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Exosome signaling in mammary gland development and cancer
... as mammary gland development and lactation but also in pathology such as breast ...the development of metastases, hence the most important improvements in morbidity and mortality will result ...
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Plk2 regulates mitotic spindle orientation and mammary gland development
... the mammary gland would cause defective centriole duplication that would result in monopolar spindles, decreased proliferation and increased apoptosis compromising outgrowth potential, as has been reported ...
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Atrazine and rat mammary gland development
... breast development, by a mean age of ...and mammary gland development through varying exposure routes, not only in rodents but in the human population as ...
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Epithelial vimentin plays a functional role in mammary gland development
... for mammary gland ...the mammary epithelium (Asiedu et ...of mammary gland ...mouse mammary ducts is significantly delayed in vivo. The Vim −/− mammary gland is ...
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Key signalling nodes in mammary gland development and cancer: Myc
... Since the early 1980s, numerous investigations have focused on c-Myc to explore its role in normal organ physiology, as well as in tumor biology [1,2]. The focus of the present review, c- Myc (hereafter referred to as ...
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ER and PR signaling nodes during mammary gland development
... the mammary epithelium is sufficient to induce side branching in virgin mammary Figure ...of mammary gland development by estrogen and ...
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Effects of BRCA1 Transgene Expression on Murine Mammary Gland Development and Mutagen-Induced Mammary Neoplasia
... in mammary gland development and tumor suppression, a transgenic mouse model of BRCA1 overexpression was ...mouse mammary tumor virus (MMTV) pro- moter/enhancer, transgenic mice expressing ...
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Insulin like growth factor binding proteins and mammary gland development
... In addition to their proposed direct actions upon cells, IGFBPs also exhibit extracellular interactions not involving the seques- tration of IGFs. For example, plasminogen is inappropriately activated during ...
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PER2 regulation of mammary gland development
... in mammary gland development and branching morphogenesis (Brisken et ...mouse mammary glands, we stained 10-week-old virgin WT and Per2 −/− mammary gland sections for ER α and ...
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Transforming growth factor β and breast cancer: Mammary gland development
... in mammary gland, indeed in most tissues, are poorly ...in mammary gland ...during mammary gland development, proliferation, and ...
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Homeobox genes in mammary gland development and neoplasia
... the mammary gland is unlikely to be devel- oped given the diverse functions and complex interactions known for many of these ...dictate mammary gland identity, form and function will require ...
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Intracellular trafficking, and function of receptor tyrosine kinases in mammary gland development
... ammary gland development (Shyamala et ...ary gland revealed a stromal and lum inal epithelial location (Shyamala et ...regulate mammary ductal ...
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Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development
... pubertal mammary gland, are an important cellular component of the gland during lactation, supplying maternal antibodies and T cells to the milk ...the mammary gland, since all ...
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ID4 regulates mammary gland development by suppressing p38MAPK activity
... Besides regulating the proliferation of cap cells, ID4 also has an important role in the proper organization of TEBs and their penetration of the fat-pad, as Id4-null TEBs exhibited cap cell detachment and stromal ...
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Key stages in mammary gland development Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ
... lobuloalvoelar development [14], Stat3 is critical for the initiation of apoptosis and involution ...in mammary gland [20,21] and the diminished involution in e/ebpδ-deficient mammary glands ...
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Key signalling nodes in mammary gland development and cancer Mitogen activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development
... of mammary tumours, and downstream ERK1/2 targets are also hyper-phosphorylated there ...normal mammary epithelial cells induces neoplastic trans- formation, highlighting the relevance of this signalling ...
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Key stages in mammary gland development Secretory activation in the mammary gland: it's not just about milk protein synthesis!
... cell to be used for triglyceride synthesis. The process is augmented by synthesis of dihydroxyacetone phosphate, a precursor of glycerol-3-PO 4 , and fatty acids from glucose. During fasting, if adipose stores are ...
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