Mammary gland development and function
Intracellular trafficking, and function of receptor tyrosine kinases in mammary gland development
... 1.1 Mammary Gland Development The mamm ary gland is a unique organ that defines the Class ...physiological function of the gland is to synthesise and deliver nutrient rich milk ...
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PER2 regulation of mammary gland development
... Recently, a role for PER proteins in maintaining progenitor stem cell division has been reported, as has a role for Clock in maintaining stem cell function in the mammary gland (Moriya et al., 2007; ...
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Homeobox genes in mammary gland development and neoplasia
... of mammary development and neoplastic ...and function in mammary gland develop- ment and neoplasia will be an exceptional ...the mammary gland has several advantages over ...
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Keratin 6 is not essential for mammary gland development
... The function of K6 in the mammary gland is not known, so we examined the expression pattern throughout mammary devel- opment, as well as the mammary gland phenotype of mice that ...
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Post-translational modifications in mammary gland development and mammary tumor progression
... Neoplasia describes the state of neoplasm growth. The type of proliferation in neoplasia is called neoplastic proliferation, as the cells do not die as they should and divide more quickly, forming tissue without normal ...
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Key stages in mammary gland development: The mammary end bud as a motile organ
... loss-of- function mutations in ...–/– mammary glands, there was a marked reduction in ductal outgrowth into the mammary fat pad that was accompanied by increased lateral branching ...of ...
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Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development
... pubertal mammary glands, nor are T cells (V Gouon-Evans and JW Pollard, unpublished ...the mammary TEBs during their estrogen-induced ...of mammary glands of eotaxin-deficient mice pro- vided the ...
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Key signalling nodes in mammary gland development and cancer: Myc
... Myc’s function in normal physiology, where its role appears to be organ specific, and in cancer where many mechanisms contribute to aberrant Myc ...the mammary gland, discussing its regulation and ...
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NEW INSIGHTS OF MAMMARY GLAND DURING DIFFERENT STAGES OF DEVELOPMENT
... Mammary gland is a unique organ with its function of milk synthesis, secretion, and involution to prepare the gland for subsequent ...The mammary epithelial cells proliferate, ...
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Plk2 regulates mitotic spindle orientation and mammary gland development
... and function of the mitotic spindle in the mammary ...the mammary gland, mitotic spindle orientation has not been well-studied, but in vitro studies in three-dimensional cultures have ...
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Epithelial vimentin plays a functional role in mammary gland development
... Vimentin, like the other IF proteins, provides different cell types with necessary mechanical stability, and mutations in IF genes are linked to many tissue-specific diseases (Toivola et al., 2015). However, it is ...
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Key stages in mammary gland development Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ
... lobuloalvoelar development [14], Stat3 is critical for the initiation of apoptosis and involution ...in mammary gland [20,21] and the diminished involution in e/ebpδ-deficient mammary glands ...
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Key signalling nodes in mammary gland development and cancer Mitogen activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development
... and function in mammary epithelial ...of mammary epithelial cells, and in models of breast cancer cell ...of mammary gland ...and mammary gland ...
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Transforming growth factor β and breast cancer: Mammary gland development
... Mammary gland development The seminal work of Daniel and coworkers [4 •• ,5] focused attention on the role of TGF-β in mammary gland develop- ment soon after its ...functional ...
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CD44 and Hyaluronan in the Regulation of Mammary Gland Development and Breast Cancer Progression
... its function during normal mammary gland development, as processes that occur in development mirror cancer progression and rely on conserved signaling pathways making it a powerful ...
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Mammary gland development: cell fate specification, stem cells and the microenvironment
... MMPs, Mammary gland, Microenvironment, Progenitor cells, Stem cells Introduction The mammary gland, which distinguishes mammals from all other animals, functions to produce and secrete milk in ...
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Functional roles of MMP14 and MMP15 in early postnatal mammary gland development
... during mammary gland morphogenesis in ...stage mammary gland development (Holmbeck et ...Interestingly, mammary glands harvested from P0 Mmp14 −/− mice generate branching ductal ...
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Investigating RUNX transcription factors in mammary gland development and breast cancer
... the mammary gland causes constitutive Wnt signalling activation and widespread squamous metaplasia (Miyoshi, et ...the mammary epithelium is fascinating: activation of a single molecule, such as ...
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Diet-induced obesity impairs mammary development and lactogenesis in murine mammary gland
... of mammary differentiation (3), was also impaired in obese ...the mammary gland, we showed that qualitatively similar changes occurred in the expression of PIA ...mouse mammary gland ...
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Rac1 Controls Both the Secretory Function of the Mammary Gland and Its Remodeling for Successive Gestations.
... during development, and for the maintenance of organ homeo- ...tissue-specific function is the mammary ...the gland is demonstrated by its ability to undergo repeated rounds of morphogenesis ...
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