MAP kinase phosphatase 2 (MKP-2)
MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice
... specific phosphatase, MAP kinase phosphatase-2 (MKP-2) has recently been demonstrated to negatively regulate macrophage arginase-1 expression, while at the same time to ...
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Over-expression of MAP kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells
... In our hands we found Adv.MKP-2 to be effective against the expression of COX-2, consistent with previous studies showing expression of this protein to be regulated by the JNK pathway (Nieminen et al. , ...
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MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana
... recombination exons 2-4 were removed. Therefore, most of the open reading frame including the phosphatase catalytic domain and the 3’UTR region of the DUSP4 gene was deleted. Although exon1, which comprises ...
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MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cells
... To study whether MKP-2 is also a potential mediator of the peripheral immune responses in CNS inflam- matory disease, we next determined the expression levels of MKP-2 in the spleen and dLN tissues during ...
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Whole genome microarray analysis of DUSP4-deletion reveals a novel role for MAP kinase phosphatase-2 (MKP-2) in macrophage gene expression and function
... protein kinase phosphatase-2 (MKP-2) is a type 1 nuclear dual specific phosphatase ...protein kinase (MAPK) signalling. However, information on the effect of MKP-2 on ...
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Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
... ERK is reduced, negative regulation is abrogated and migration enhanced. In contrast, p38 MAPK, believed to provide a positive chemotaxis signal, was not significantly altered in our studies. However, it should be noted ...
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Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
... ERK is reduced, negative regulation is abrogated and migration enhanced. In contrast, p38 MAPK, believed to provide a positive chemotaxis signal, was not significantly altered in our studies. However, it should be noted ...
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Mitogen activated protein kinase phosphatase 1 in rat arterial smooth muscle cell proliferation
... inactivate MAP kinases, MKP-1 has been studied the most ...p42 MAP kinase by dephosphorylating Thr183 and Tyr185, both in vitro and in vivo (5), and an active site mutant of MKP-1 without enzymatic ...
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T cell hypo-responsiveness against Leishmania major in MAP kinase phosphatase (MKP) 2 deficient C57BL/6 mice does not alter the healer disease phenotype
... Leishmania species are protozoan parasites that are transmitted by infected female sandflies and cause a wide spectrum of diseases ranging from self-healing cutaneous lesions to fatal systemic disease. After entering ...
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Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6
... protein kinase; MKK: MAP kinase kinase; JNK: cJun N-terminal kinase; BMDM: Bone marrow derived macrophages; IL-10: Interleukin 10; WT: Wild type; SB: SB203580 (p38 α / β inhibitor); SP: ...
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The function, regulation and therapeutic implications of the tumor suppressor protein, PML
... Big MAP kinase 1; HDACs: Histone deacetylases; HIPK2: Homeodomain‑ interacting protein kinase‑2; INFs: Interferons; JAK/STAT: Janus kinase/signal transducer and activator of ...
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DUSPs, to MAP kinases and beyond
... There are currently 25 genes in the Human Genome Organization database designated as DUSPs, namely DUSP1-28 — with DUSP17, -20, and −23 redundantly assigned as DUSP19, -18, and −25, respectively. Within the 25 DUSPs, ...
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Mitogen-activated protein kinase phosphatase-2 deletion impairs synaptic plasticity and hippocampal-dependent memory
... As LTP is proposed to be a molecular correlate of memory, our data indicating deficits in hippocampal-dependent memory processes in MKP-2 ⫺/⫺ mice supports this view. Numerous studies have reported that both ...
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FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model
... serine/threonine kinase 1; Bcl-2: B-cell CLL/lymphoma 2; CIP2A: cancer- ous inhibitor of protein phosphatase 2A; EDTA: ethylenediaminetetraacetic acid; EGTA: ethylene glycol-bis(β-aminoethyl ...
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NPs — heart hormones that regulate brown fat?
... Children with Down syndrome (DS) have a markedly increased risk of devel- oping acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic leukemia compared with that of children without DS. Despite recent break- ...
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Role of the stress activated protein kinases in endothelin induced cardiomyocyte hypertrophy
... of MAP kinases (27, 43, 44), it has become apparent that many of the stimuli which induce myocyte hypertrophy, including agonists with Gq-coupled receptors, activate the SAPKs and, in some cases, p38 (10, 11, 41, ...
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REGULATION OF REPRESSIBLE ACID PHOSPHATASE BY CYCLIC AMP IN SACCHAROMYCES CEREVISIAE
... The bcyl mutation, which suppresses the cyrl-2 mu- tation by allowing activity of a cyclic AMP-independent protein kinase, also allows acid phosphatase synthesis without [r] ...
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The defense response in Arabidopsis thaliana against Fusarium sporotrichioides
... approximately 2 g of this fine powder was added to 5 mL of PBS buffer containing 1% Triton-X 100, 1 mM phenylmethanesulfonyl fluoride (PMSF) and 1/1000 protease inhibitor cocktail (Sigma-Aldrich, MO, USA) and the ...
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Intermittent hypoxia-induced protein phosphatase 2A activation reduces PC12 cell proliferation and differentiation
... Real-time quantitative polymerase chain reaction (qPCR) RNA was extracted from PC12 cells using TRIzol re- agent (Invitrogen, USA), and cDNA was synthesized using the Verso™ cDNA kit (Thermo, USA). Real-time PCR was ...
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MAPK activation in mature cataract associated with Noonan syndrome
... A 42-year-old man experienced decreased visual acuity in the right eye before 2 years, but did not seek treatment. Later, he became aware of severely decreased visual acuity in the right eye several months ago and ...
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