MAP kinases
CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction
... JNK MAP kinases, inactivation of NF-kB protective pathways and mitochondrial dysfunction are downstream mediators of this CYP2E1-LPS/TNF potentiated hepato- ...
19
The role of MAP kinases in the regulation of mechanical load-induced procollagen gene expression in cardiac fibroblast
... Mechanical forces have also been shown to activate this pathway in a variety o f cell types of the cardiovascular system. Static mechanical stretch of cardiac myocytes has been shown to induce activation of several ...
279
Selective regulation of MAP kinases and Chemokine expression after ligation of ICAM-1 on human airway epithelial cells
... of MAP kinases in both A549 cells and a fully differ- entiated primary culture of NHBE ...of MAP kinases, or an increase in cytokine gene expression and ...
10
TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes
... This study shows that TBK1, similar to IKKε, is involved in inflammatory nociceptive processing in the spinal cord and might therefore constitute a promising target for pharmacological intervention in pain. Our data ...
13
DUSPs, to MAP kinases and beyond
... non- MAP kinase targets may result from indirect ...through MAP kinase-dependent pathways as discussed previously, the observed changes in STAT activation may also be secondary effects due to autocrine or ...
10
Mite and cockroach proteases activate p44/p42 MAP kinases in human lung epithelial cells
... The understanding of the allergen-induced early signaling mechanisms in epithelial cells is critical to our knowledge of the mechanisms and modulation of airway inflamma- tion and induction of innate and adaptive ...
12
TGF-β1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases
... CA) was added for the final 4 hours and the incorporation was terminated by washing the cells with PBS twice. The cells were lysed with 0.2 N NaOH and the radioactivity was counted with a scintillation counter (Beckman ...
10
In vivo regulation of MAP kinases in Ratus norvegicus renal papilla by water loading and restriction
... demonstrate that in the rat, at the basal level of hydration, which is associated with the excretion of a concentrated urine ( z 2,000 mOsm/kg), there is a marked activation of the three members of the MAPK family when ...
9
Activation of MAP kinases by green leaf volatiles in grasses
... Abstract Objective: Previously we have shown that mechanical wounding and volatiles released from cut grass, activated a 46 and 44 kDa mitogen-activated protein kinase MAPK in the mode[r] ...
6
Characterization of signaling pathways activated by the interleukin 1 (IL 1) receptor homologue T1/ST2 A role for Jun N terminal kinase in IL 4 induction
... Members of the Toll/IL-1 receptor superfamily are structur- ally related and are primarily categorized on the basis of a conserved intracellular region called the TIR domain. It previ- ously has been shown in the case of ...
7
Acute hypertension activates mitogen activated protein kinases in arterial wall
... phorylation by the MAP kinases. Fos and Jun proteins com- bine to form stable AP-1 heterodimers, which bind to AP-1 consensus sequences present in numerous genes associated with cell proliferative and ...
8
Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells
... the MAP kinases Erk1/2 and, when used in conjunction, enhances cell death induced by platinum compounds in a large subset of colorectal cancer cell ...
13
Role of the stress activated protein kinases in endothelin induced cardiomyocyte hypertrophy
... of MAP kinases (27, 43, 44), it has become apparent that many of the stimuli which induce myocyte hypertrophy, including agonists with Gq-coupled receptors, activate the SAPKs and, in some cases, p38 (10, ...
11
The cloning and characterisation of link1: A LIM-domain containing protein kinase
... protein kinases have been reported that are not closely related to the sequence of any other protein kinase superfamily ...Such kinases have been labelled "dual-specificity" kinases (Lindberg ...
151
Stimulation of MAP kinase pathways after maternal IL-1β exposure induces fetal lung fluid absorption in guinea pigs
... protein kinases (MAP kinases) may regulate β AR stimulation of lung fluid absorption by affecting Na,K-ATPase mem- brane expression ...activated MAP kinase pathways in fetal guinea pig lungs ...
8
LPS Induced Proliferation and Chemokine Secretion from BEAS 2B Cells
... Thus MAP-Kinases p38 and JNK, tyrosine kinases, and PI3-kinase are involved in the signaling cascade from the LPS-CD14-complex on the cell surface to the increased cell proliferation and expression ...
12
Flavocoxid, a dual inhibitor of COX 2 and 5 LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis
... In a second experiment, six mice per group were subjected to sham operation or CLP, and NF-B, MAP kinases, TNF-a, IL-6, IL-10, and b-arrestin 2 expression was determined in the lung and [r] ...
12
Plasma membrane-bound AGC3 kinases phosphorylate PIN auxin carriers at TPRXS(N/S) motifs to direct apical PIN recycling
... Previously, we have shown that the PID kinase and PP2A phosphatase act antagonistically on PIN polarization through reversible phosphorylation of the PINHL (Friml et al., 2004; Michniewicz et al., 2007). Here, we ...
13
A Duo of Potassium Responsive Histidine Kinases Govern the Multicellular Destiny of Bacillus subtilis
... Potassium constitutes the signal for the fine-tuned intercon- nection of social sliding and biofilm development. Potassium represents the most abundant ion in the cytoplasm (~200 mM in E. coli versus 7 mM content in LB ...
16
Characterization of the Sak kinase interaction with cyclin B1 and Gadd45a
... Polo-like Kinases Function and Members 1 The Structure of the Polo-like Kinases 2 Plks Expression and Kinase Activity 4.. Plks Localization 5.[r] ...
115