MAPK and signal transduction
Original Article Expression of miR-144, titin-Ab and MAPK signal transduction pathway related proteins in pre-eclampsia patients
... while MAPK signal transduc- tion pathway up-regulates IL-1β-induced MMP-9 activity in amnion cells, thus playing an impor- tant role in preterm labor [19, ...of MAPK signal transduction ...
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Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia
... kinase-based signal transduction pathways that nor- mally translate extracellular stimuli into appropriate homeostatic responses can powerfully contribute to leukemogenesis by enabling leukemic cells to ...
10
Interleukin-1β regulates the expression of glucocorticoid receptor isoforms in nasal polyps in vitro via p38 MAPK and JNK signal transduction pathways
... exact MAPK family signal pathways that may regulate the GR expression in the mucosa of GC- resistant CRS, altering the GRα/GRβ ratio and thereby changing the GC sensitivity of the inflamed nasal mu- ...
10
p38 MAPK is a likely component of the signal transduction pathway triggering rapid cold hardening in the flesh fly Sarcophaga crassipalpis
... p38 MAPK activation is most robust in life stages where the RCH response is most pronounced, ...phospho-p38 MAPK activation in flies reared at 25 than at 20°C ...p38 MAPK is activated less strongly ...
6
Involvement of the p38 MAPK-NF-κB Signal Transduction Pathway and COX-2 in the Pathobiology of Meniscus Degeneration in Humans
... p38 MAPK, its phosphorylated/activated form (p-p38), its target NF- κ B (p50–p65 dimer), and COX-2 in ruptured menisci and investigated their involvement in MD ...
7
Effect of electroacupuncture stimulation at Zusanli acupoint (ST36) on gastric motility: possible through PKC and MAPK signal transduction pathways
... extracellular signal related ki- nases 1 and 2 (ERK1/2), the C-jun terminal kinase (JNK), and the p38 MAPK are known to play important roles in the intracellular signaling response to extracellu- lar ...
8
Hog1 Mitogen-Activated Protein Kinase (MAPK) Interrupts Signal Transduction between the Kss1 MAPK and the Tec1 Transcription Factor To Maintain Pathway Specificity
... of MAPK signaling is the activation of specific genes through the control of DNA-binding transcrip- tional ...pathway MAPK, Kss1, binds to and inhibits Ste12-Tec1; however, when phosphorylated by Ste7, Kss1 ...
11
Four dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors
... eukaryotic signal transduction, and these pathways are evolutionarily conserved in cells from yeast to mammals (reviewed in Chang and Karin, 2001; Lewis et ...different MAPK families, including the ...
10
Review Article Role of long non-coding RNAs in cancer and associated signal transduction pathways
... this signal- ing cascade [49, 50]. ERK/MAPK pathway was found to be inactivated in the gallbladder carci- noma (GBC) cell lines after MALAT1 knockdown which indicated that MALAT1 might serve as an oncogenic ...
14
The regulation of TGFβ signal transduction
... (extracellular signal-regulated kinase), LIMK2 (LIM domain kinase 2), JNK (Jun N- terminal kinase), p38 (p38 MAPK), PAR6 (partitioning-defective 6 homolog), Rho (Ras homolog), ROCK (Rho-associated, ...
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A transcriptome analysis identifies potential preventive and therapeutic
... protein signal transduction response to decreased oxygen levels small GTPase mediated signal transduction response to hypoxia response to oxygen levels acute inflammatory response regulation ...
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Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
... p38 MAPK phosphor- ylation in the various leukocyte subsets, whereas khat-extract mediated a significant increase in phos- phorylation of this cell stress ...p38 MAPK phosphorylation in PBMCs in vitro , and ...
13
Reactive oxygen species in signal transduction
... Activation of NF-κB is often associated with the formation of ROS, since a number of stimuli that activate NF-κB can also cause ROS forma- tion. It has been shown that ROS are mediators in the phosphorylation of ...
9
Signal Transduction in the Footsteps of Goethe and Schiller
... hand, terminates signalling through Gab2, this mecha- nism represents a novel negative feedback mechanism for the control of growth factor signalling. Interestingly, this mechanism does not apply for Gab1-mediated ...
6
Signal transduction inhibitors in treatment of myelodysplastic syndromes
... More recently, another p38 MAPK inhibitor, ARRY-614, has shown promising activity in MDS. This compound can block both the p38 MAPK and the Tie-2 pathway. Tie-2 pathway has been noted to complement P38 MAP ...
11
RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it
... RAS/MAPK signal transduction path- way that display hypertrophic cardiomyopathy (HCM); the model from the former paper was from a gain-of-function Raf1 mutation, and the model from the latter paper ...
5
Signal transduction in vasculogenesis and developmental angiogenesis
... p38 MAPK to induce endothelial cell ...kinase/extracellular signal-regulated kinase kinase); MAPK (mitogen-activated protein kinase); PKD (protein kinase D); HDAC7 (histone deacetylase 7); PI3K ...
12
The biological effect of 125I seed continuous low dose rate irradiation in CL187 cells
... the MAPK signal transduction, the expression changes of epidermal growth factor receptor (EGFR) and Raf under continuous low dose rate irradiation (CLDR) and/or EGFR monoclonal antibodies were ...
9
Signal Transduction with Hybridization Chain Reactions
... optical signal created during qRT-PCR is physically separated from RNA, such that this technique offers no spatial information con- cerning the transcript whose presence and quantity the technique ...
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A Systems Approach to Cellular Signal Transduction
... of signal flow through diverging pathways downstream of the receptor, our calculations provided a mechanistic explanation for the clinical observation that therapeutic tyrosine kinase inhibitors can control tumor ...
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