Mapt gene
Regulation of human MAPT gene expression
... the MAPT gene, which en- codes Tau protein, has been the subject of few articles; more articles have focused on the function of Tau pro- tein or its roles in various ...include MAPT haplotypes and ...
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Role of the H1 haplotype of microtubule-associated protein tau (MAPT) gene in Greek patients with Parkinson's disease
... The MAPT gene is encoded on chromosome 17q21 in the centre of a 900 kb fragment between two extended haplo- types, H1 and H2, which cover the entire MAPT gene ...the MAPT gene, ...
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Intrafamilial phenotypic heterogeneity in a Taiwanese family with a MAPT p.R5H mutation: a case report and literature review
... covering MAPT , GRN , VCP , FUS , CHMP2B , and TARDBP on the proband, followed by Sanger sequencing of candidate genes in eight family ...of MAPT gene, ...
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<p><em>MAPT</em> promoter CpG island hypermethylation is associated with poor prognosis in patients with stage II colorectal cancer</p>
... both MAPT gene expression and methylation data. MAPT gene was differentially expressed and methy- lated (data not ...series, MAPT promoter CpG island is frequently methylated in stage ...
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The Role of Variation at AßPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease
... in MAPT are associated with risk of other neurodegenerative ...the MAPT locus using a gene-wide approach (p = ...the MAPT gene and has previously been implicated in other ...
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Original Article Whether Alzheimer’s diseases related genes also differently express in the hippocampus of Ts65Dn mice?
... angiopathy. Mapt gene encodes the microtu- bule-associated protein tau which is differen- tially expressed in the nervous system, depend- ing on is relative to the stage of neuronal matu- ration and neuron ...
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<p>Nimodipine Improves Cognitive Impairment After Subarachnoid Hemorrhage in Rats Through IncRNA NEAT1/miR-27a/MAPT Axis</p>
... the gene by binding to the target ...(MAPT) gene is synthesized in large quantities and causes brain damage and cognitive dysfunction by inducing neural in fl ammation and brain metabolic ...
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Multiple cervical artery dissections
... Abstract—Background: Frontotemporal dementia with parkinsonism is often linked to chromosome 17 and is related to mutations in the MAPT gene. In some families the genetic basis is still unknown. The authors ...
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TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
... Humanized tau mice (hTau) lack the endogenous mouse Mapt gene (mMapt − / − ), but instead express the full-length human MAPT gene driven under the endogenous human MAPT promoter [25, 26][r] ...
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Different tau species lead to heterogeneous tau pathology propagation and misfolding
... human MAPT mutant carriers compared to sporadic AD We hypothesized that the mechanisms of tau deposition are different in sporadic tauopathies than when a mutation of MAPT gene is ...of MAPT ...
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The role of <em>MAPT</em> gene in Chinese dementia patients: a P301L pedigree study and brief literature review
... the MAPT gene, the P301L mutation has been associated with clinical and pathologic ...of MAPT gene in Chinese FTD patients remain largely ...
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Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
... the MAPT gene binds to microtubules and is important for maintaining neuronal morphology and ...of MAPT pre-mRNA generates six major tau isoforms in the adult central nervous system resulting in tau ...
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MAPT p.V363I mutation
... (MAPT) gene are implicated as a cause of CBS and related tauopathy spectrum ...these MAPT mutations is the variant ...the MAPT microtubule-binding ...
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Original Article Proteomic analysis of immature rat pups brain in response to hypoxia and ischemia challenge
... Abstract: Hypoxia and ischemia significantly affects perinatal brain development, even worse in preterm infants. However, the details of the mechanism leading to permanent brain damage after hypoxia-ischemia attack have ...
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Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders
... LD MAPT by leveraging the strong haplotype specific expression of MAPT exon 3 to gauge SNP ...human MAPT locus in neuronal cell culture models and demonstrated MAPT locus expression is under ...
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<p>Integrative gene expression profiling reveals that dysregulated triple microRNAs confer paclitaxel resistance in non-small cell lung cancer via co-targeting MAPT</p>
... integrative gene expression pro fi l- ing was applied to explore the possible novel underlying molecular mechanism of paclitaxel-resistance in NSCLC in our current ...
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Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation
... ( MAPT) , FTLD-TDP (sporadic, FTLD-TDP- GRN , FTLD-TDP- C9ORF72 ) and sporadic FTLD-FUS, using western blot and 2D-DIGE (Two-Dimensional fluorescence Difference Gel Electrophoresis) ...
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C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers
... controls, MAPT and GRN mutations carriers (p-value ...between MAPT cases versus controls and GRN cases versus con- trols, ruling out a direct influence of C9orf72 methylation level on C9orf72 expression in ...
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A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies
... To investigate the effects of TAOKs on tau phosphor- ylation in human neurons, induced pluripotent stem cells (iPSCs) from two control iPSC lines and one iPSC line generated from an individual with the FTLD- associated ...
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Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review
... H1 MAPT haplotype increases PSP risk and has been associated with higher expression of 4R tau, but it is too common in the general population to ex- plain the unusual 4R tau predominance in the present family ...
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