Master regulator
A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor
... The activity of the master regulator of carbohydrate utilization from E. coli—the cyclic AMP receptor protein (CRP)—is also stimulated by a brief exposure to carbon limitation. In the case of CRP, this is ...
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Discovery of a Master Regulator of Injury and Healing: Tipping the Outcome from Damage toward Repair
... Disease processes provoke a balancing act between tissue damage and repair. In the 1980s, the discovery that tumor necro- sis factor (TNF)- α is a general mediator of disease-related injury led to the development of ...
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Analysis of Activator and Repressor Functions Reveals the Requirements for Transcriptional Control by LuxR, the Master Regulator of Quorum Sensing in Vibrio harveyi
... B acteria use the cell-cell communication process called quo- rum sensing to measure and respond to changes in the num- ber and species relatedness of bacteria in the environment. Quorum sensing involves the production ...
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Selective Pressure for Biofilm Formation in Bacillus subtilis: Differential Effect of Mutations in the Master Regulator SinR on Bistability
... The master regulator SinR represses all the corresponding genes, and re- pression of these key biofilm genes is lifted when SinR interacts with its cognate an- tagonist ...
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Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation
... master regulator functions to activate pathways essential for the many features that define cell ...multifaceted master regulator through activation of other master ...developmental ...
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A MYB (MYBL1) transcription factor is a master regulator of male meiosis
... male-specific master regulator of several crucial meiotic ...a master regulator of meiotic genes that are involved in multiple processes in spermatocytes, particularly those required for cell ...
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Smoothened is a master regulator of adult liver repair
... a master regulator of hepatic epithelial regeneration based on its ability to promote mesenchymal-to-epithelial transitions in a sub- population of HSC-derived MFs with features of multipotent ...
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Aborted microspores acts as a master regulator of pollen wall formation in Arabidopsis
... Mature pollen is covered by durable cell walls, principally composed of sporopollenin, an evolutionary conserved, highly resilient, but not fully characterized, biopolymer of aliphatic and aromatic components. Here, we ...
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MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression
... Systemic side effects like hepatic and cardiac toxicity as well as central nervous system disorders caused by the small molecules p38MAPK inhibitors have hindered their translational use. This might be attributed to the ...
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Regulation of the master regulator FOXM1 in cancer
... FOXM1 is a crucial regulator of many biological pro- cesses and tissues, and dysregulation of FOXM1 can sig- nificantly contribute to tumorigenesis and cancer progression. For its potential as a target for cancer ...
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Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Postinfluenza Bacterial Superinfection
... Our data show that the early type I IFN responses did not affect the reduced susceptibility that was found in the mice deficient in IFNAR at day 7, further supporting our position that a switch in the immune response ...
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Fur Is the Master Regulator of the Extraintestinal Pathogenic Escherichia coli Response to Serum
... ABSTRACT Drug-resistant extraintestinal pathogenic Escherichia coli (ExPEC) strains are the major cause of colisepticemia (coli- bacillosis), a condition that has become an increasing public health problem in recent ...
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Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?
... Under steady-state conditions, multiple mechanisms operate in concert to inhibit mTOR expression and/or activity and maintain/restore T cell homeostasis [15]. After the recognition of antigen by naïve T cells, mTOR ...
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Glucocorticoid-induced leucine zipper (GILZ) in immuno suppression: master regulator or bystander?
... Since total GILZ KO mice were also used in this study, one might speculate that potential effects of GILZ KO could have been compensated by the induction of Anxa1 or other GCinducible ge[r] ...
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Specific expression and export of the Plasmodium falciparum Gametocyte EXported Protein 5 marks the gametocyte ring stage
... AP2-G master regulator of parasite sexual development sug- gests that, after sexual commitment, differentiation pro- gresses through multiple checkpoints in the early phase of ...
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A Gene Regulatory Program in Human Breast Cancer
... ABSTRACT Molecular heterogeneity in human breast cancer has challenged diagnosis, prognosis, and clinical treatment. It is well known that molecular subtypes of breast tumors are associated with significant differences in ...
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Four decades of Hox gene investigation and many more to go
... Forty years ago, Ed Lewis established for the first time the organization of homeotic genes along the chromosome and its importance in embryo patterning. To celebrate this seminal discovery, the International Journal of ...
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Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One Carbon Metabolism Genes
... potential master regulators have arisen recently in order to adapt to evolving ...candidate master regulator of OCM, miR-125/351, that may have functional relevance in relatively recent evolutionary ...
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Iron deficiency in critically ill patients: highlighting the role of hepcidin
... Th e two main contributing factors for anemia in the critically ill are infl ammation and iron defi ciency, which have opposite eff ects on iron metabolism (see above). Until recently, infl ammation, rather than iron defi ...
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Reconfiguration of Transcriptional Control of Lysine Biosynthesis in Candida albicans Involves a Central Role for the Gcn4 Transcriptional Activator
... essential regulator of the lysine biosynthetic pathway in ...the master regulator Gcn4 under amino acid starvation conditions (15, ...essential regulator of lysine biosynthesis in ...
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