Matrix metalloproteinase-2
Original Article Serum levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 have clinical significance for the evaluation of the prognosis of patients with ruptured intracranial aneurysms after interventional therapy
... of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) before and after interventional therapy of ruptured intracranial aneurysm (IA), as well as their ...
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SERUM MATRIX METALLOPROTEINASE-2 AS A BIOMARKER FOR DIAGNOSIS OF IDIOPATHIC EPILEPSY
... 7. Serum matrix metalloproteinase -2 (MMP-2) levels will be assessed interictally. Five milliliters of blood was collected from the antecubital vein into vacutainer tubes without ...
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The effect of tomato juice on the expression of matrix metalloproteinase-2 (MMP-2) and type-1 collagen on the vaginal wall of the menopausal rats
... Background: Aging is a multifactorial phenomenon that is characterized by a decrease in physiological functions that increases with age. Free radicals cause oxidative stress, which plays a role in the aging process. The ...
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Active synovial matrix metalloproteinase 2 is associated with radiographic erosions in patients with early synovitis
... In view of the analogies between erosion formation in arthritis and tumor invasion in cancer, we hypothesized that activated MMP-2 and possibly MMP-9 might play an important role in the early stages of invasion of ...
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Matrix Metalloproteinase-2 as Potential Marker of Early Nephropathy in Type 1 Diabetes
... important. Matrix metalloproteinases-2 (MMP-2) regulates a variety of cellular functions including apoptosis and ...(Group 2) and the last 100 patients had disease duration more than 5 years ...
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Aging is associated with increased activities of matrix metalloproteinase 2 and 9 in tenocytes
... MMP-3, MMP-10, MMP-12, MMP-27 and TIMP-2 in either ruptured or painful tendons [5-8,10]. However, there is currently no direct evidence of an association between age and the activities of MMPs. Gelatinases ...
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Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion
... In order to detect proteolytic activity in conditioned media (CM) collected after 48–72 h culture, substrate-gel- electrophoresis (Zymography) on gels containing gelatin as the substrate were used as was described by our ...
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CD147 and matrix-metalloproteinase-2 expression in metastatic and non-metastatic uveal melanomas
... CD147 is proposed not only to be involved in vasculo- genic mimicry formation but also in the regulation of angiogenesis via VEGFR-2. Tang et al. have recently re- ported that the up-regulation of EMMPRIN in MDA- ...
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Upregulated matrix metalloproteinase-2 and downregulated tissue factor pathway inhibitor-2 are risk factors for lymph node metastasis and perineural invasion in pancreatic carcinoma
... indicated that high-level expression of MMP-2 protein is an independent risk factor for developing LNM; the combina- tion of intratumoral hypoxia-inducible factor-1 α , vascular endothelial growth factor, and ...
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Matrix metalloproteinase-2 is elevated in midtrimester amniotic fluid prior to the development of preeclampsia
... When further subdivided into groups of GH, PET and sPET, we found a significant difference in MMP-2 amni- otic fluid levels between normotensive women and women who developed PET or sPET. No significant differ- ...
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Integrin Alpha V Beta 3 Matrix Metalloproteinase 2 (MMP 2), Cross Talk
... breast cancer cases of different stages from the institutional hospital catchment area. Patients were offered treatment according to the stage of the disease, either surgery followed by chemotherapy and ± Radiotherapy or ...
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High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2)
... Activation of pro-MMP-2 proceeds on the cell surface and is mediated by a tri-molecular complex of MT1-MMP, TIMP-2 and MMP-2 [15,16]. Collagen type I (Col I) has been shown to stimulate ...
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Platelet aggregation induced by Caco 2 cells: regulation by matrix metalloproteinase 2 and adenosine diphosphate
... o-phenanthroline, or APT102, which was added 2 min prior to tumor cells. When TCIPA reached 50% maximal light transmission, the reaction was terminated by 10-fold dilution with physiologic saline. Resting ...
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Relationship between single-nucleotide polymorphism of matrix metalloproteinase-2 gene and colorectal cancer and gastric cancer susceptibility: a meta-analysis
... In this study, the significant relationship between MMP- 2(C-1306T) polymorphism and CRC risk was found in reces- sive model and codominant model (TT vs CC/CT: OR: 2.39, 95% CI: 1.30–4.37, P = 0.005; TT vs CC: OR: ...
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Immunohistochemical expression of Matrix Metalloproteinase-2 (MMP-2) in inguinal hernia
... The exact etiology of inguinal hernias is still being widely experimented and remains unclear. Many factors predisposing to hernias have been proposed which includes; an open processus vaginalis, increased intraabdominal ...
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Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution
... The crude membrane fraction from the rat uterus was iso- lated as previously reported [17,23]. Briefly, uterine tissue samples were homogenized in 2 ml of Tris buffer contain- ing 0.25 M sucrose using a Teflon ...
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Matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2, and transforming growth factor beta 1 in the aqueous humor and serum of patients with pseudoexfoliation syndrome
... TGF- β 1 in aqueous humor, without a serum levels’ compari- son, and detected the highest concentration with PEX glau- coma patients. There was a significant correlation between the aqueous levels of these molecules, and ...
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The Distribution of Matrix Metalloproteinase-2, Tissue Inhibitor of Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-4 in Psoriatic Skin
... MMP-2 expressed in few to moderate (+/++) keratinocytes and in moderate to numerous (++/+++) dermal connective tissue cells in healthy skin (Fig. 1). In tissue samples of psoriasis patients numerous (+++) ...
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Modulation of monocyte matrix metalloproteinase 2 by breast adenocarcinoma cells
... The monocyte cell line THP-1, the estrogen receptor positive human breast cancer cell line MCF-7 and the estrogen recep- tor negative breast cancer cell line MDA-MB-231 were obtained from the American Type Culture ...
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Synergistic and protective effect of atorvastatin and amygdalin against histopathological and biochemical alterations in Sprague-Dawley rats with experimental endometriosis
... The aim of the present study was to evaluate the protective effects of combined atorvastatin and amygdalin in a rat model of endometriosis. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), matrix ...
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