Matrix metalloproteinase-9
Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase 9 with enhanced expression in a model of membranous nephropathy
... extracellular matrix has remained largely unex- ...man matrix metalloproteinase-9 (MMP-9, or gelatinase B) suggested the identity of this activity, which was confirmed by ...
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Kupffer-derived matrix metalloproteinase-9 contributes to liver fibrosis resolution
... Figure 5. Effect of KC-derived MMP9 on transcription of MMPs and TIMPs. Total mRNA was extracted from liver at indicated time points. The levels of (A) MMP9, (B) MMP13, (C) MMP2, (D) MMP14, (E) TIMP1 and (F) TIMP2 were ...
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Original Article Serum levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 have clinical significance for the evaluation of the prognosis of patients with ruptured intracranial aneurysms after interventional therapy
... of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) before and after interventional therapy of ruptured intracranial aneurysm (IA), as well as their ...
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Elevated Levels of Matrix Metalloproteinase 9 and Tissue Inhibitor of Metalloproteinase 1 during the Acute Phase of Kawasaki Disease
... Previously, matrix metalloproteinase 9 (MMP-9), which is secreted complexed to tissue inhibitor of metalloproteinase 1 (TIMP-1), has been implicated in abdominal aortic aneurysm ...
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Assessing the Effect of Matrix Metalloproteinase-9 on the Growth of Mice Teeth by NMR
... of matrix metalloproteinases and their inhibitor, TIMP-1, in developing human osteophytic ...of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV COLLAGENASE = gelatinase B) in ...
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Matrix metalloproteinase 9 modulates collagen matrices and wound repair
... Acute and chronic injuries are characterized by leukocyte infiltration into tissues. Although matrix metalloproteinase 9 (Mmp9) has been implicated in both conditions, its role in wound repair ...
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Correlation of Matrix Metalloproteinase-9 (MMP-9) expression and bone destruction in Chronic Suppurative Otitis Media (CSOM) patients with cholesteatoma at Adam Malik General Hospital Medan-Indonesia
... Introduction: Cholesteatoma is a cyst which coated by stratified squamous epithelium containing keratin epithelial desquamation. The recurrence and bone destruction arerelevant features in cholesteatoma pathophysiology, ...
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Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline
... Notes: aMs from ahr−ns (n=10), ahr−s (n=13) or ahr+s (n=8) were incubated for 24 hr. The level of MMP-9 (A) and TIMP-1 (B) in the culture supernatants was determined by enzyme-linked immunosorbent assays. The ...
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Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity
... The level of MMP-9 production in the untreated TA synoviocytes was below the detection limit level; therefore, the concentration of MMP-9 produced by TA synoviocytes, when treated, remained below the ...
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Serum Level of Matrix Metalloproteinase-9 in Patients with Salivary Gland Tumor
... Problem: Matrix metalloproteinases (MMPs) have been im- plicated in the pathogenesis of certain diseases and cancers via tissue destruc- tion and can be secreted into the blood ...
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C-1562T polymorphism of matrix metalloproteinase-9 (MMP-9) gene associated with elevated level of plasma MMP-9 concentration in patient with acute myocardial infarction (AMI) in Denpasar-Bali
... A cross-sectional study evaluating the association between single-nucleotide polymorphisms (SNPs) in the promoter regions of MMP-9 was conducted in Sanglah General Hospital. 70 patients were enrolled and divided ...
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Role of α Tubulin Acetylation and Protein Kinase D2 Ser/Tyr Phosphorylation in Modulation by Ghrelin of Porphyromonas gingivalis Induced Enhancement in Matrix Metalloproteinase 9 (MMP 9) Secretion by Salivary Gland Cells
... Moreover, relying on the literature evidence as to the role of cytoskeleton MT stabilization in the secretory vesicle trafficking [11] [15] [16], we assessed the impact of the LPS and ghrelin on the acinar cell secretion ...
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Lipoprotein docosapentaenoic acid is associated with serum matrix metalloproteinase-9 concentration
... Low rates of CHD were found in Greenland Eskimos who are exposed to a diet rich in n-3 fatty acid fish oil [9]. Such diets have also been suggested to reduce the risk of inflam- matory bowel disease [10]. ...
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Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2
... extracellular matrix proteins, cytokines, and ...that matrix metalloproteinase (MMP)-9 and MMP-2 contrib- ute to neuropathic pain following nerve injury ...MMP- 9/2 also enhance ...
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Matrix metalloproteinase 9 modulates intestinal injury in rats with transmural colitis
... ity and expression in all specimens, especially on days 7 and 10 after TNBS enema instillation. However, zymographic anal- ysis showed no significant difference in MMP-2 activity be- tween control and colitic rats. ...
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Matrix Metalloproteinase 9 Facilitates West Nile Virus Entry into the Brain
... In this study, we focused on MMP9 because its expression and activity are highly inducible (26) and it was the most-highly influenced by WNV infection. In the murine brain, MMP9 was upregulated by WNV at mRNA and protein ...
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Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser <em>in situ</em> keratomileusis
... and CS concentrations did not recover to the preoperative levels even by 3 months following LASIK. These results indicated that the corneal wound healing did not terminate at 3 months after LASIK. A study in rabbits ...
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Matrix metalloproteinase-9 in the pathophysiology and diagnosis of dry eye syndrome
... ing tear MMP-9 activity rather than concentration, MMP-9 activity increased with categorical severity of tear dysfunc- tion using the Dry Eye Workshop (DEWS) criteria and tear MMP-9 activities showed ...
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Elevated matrix metalloproteinase 9 in patients with systemic sclerosis
... Detection of MMP-9 activities by gel zymography MMP-9 and MMP-2 activities were also tested by gelatin zymography. A 0.5-µl sample of serum diluted in 30 µl of SDS buffer was separated in 10% SDS–PAGE gel ...
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Original Article Immunohistochemical expression of matrix metalloproteinase-9 and inhibitor of matrix metalloproteinase-1 in prostate adenocarcinoma
... forming a complex with pro-MMP-9 that blocks activation of the latter by stromelysins [8]. TIMPs, which have been described as potential MMP inhibitors, currently are regarded as pro- teins with pro-oncogenic and ...
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