matrix metalloproteinase (MMP)
Active synovial matrix metalloproteinase 2 is associated with radiographic erosions in patients with early synovitis
... matrix metalloproteinase (MMP) family are thought to play a central role in the degradation of the extracellular matrix of articular bone and ...gelatinases MMP-2 [9,10] and ...
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Original Article Matrix metalloproteinase-3 and -9: possible biomarkers of infliximab efficacy in ankylosing spondylitis (AS)?
... serum Matrix Metalloproteinase (MMP)-3 and -9 in active ankylosing spondylitis (AS) during infliximab treatment and to evaluate whether MMP-3 and MMP-9 were associated with clinical ...
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The Interaction of Stroke Risk Factors, Clinical Outcomes and Matrix Metalloproteinase 9 Levels with the Reduction of Vascular Endothelial Growth Factor A Levels at the Incidence of Brain Edema in Acute Ischemic Stroke Patients
... [13]. Matrix metalloproteinase (MMP) can increase the permeability of the blood-brain barrier in response to hypoxic-ischemic injury, multiple sclerosis, or infection ...[14]. MMP increases ...
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Original Article Serum levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 have clinical significance for the evaluation of the prognosis of patients with ruptured intracranial aneurysms after interventional therapy
... of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) before and after interventional therapy of ruptured intracranial aneurysm (IA), as well as their ...
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Matrix metalloproteinase 3 inhibitor retards treadmill running induced cartilage degradation in rats
... lage matrix degradation, MMPs have long been consid- ered excellent potential treatment for OA, and inhibition of their activities has proven to be efficacious in a variety of models of experimentally induced as ...
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The matrix metalloproteinase and insulin-like growth factor system in oral cancer – a prospective clinical study
... In conclusion, high MMP-3 and low IGF-1 and IGFBP-3 serum values are associated with OSCC. IGF-1 and IGFBP-3 and especially the combination of both the factors represent a novel potential prognostic tool of ...
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Fluid-induced, shear stress-regulated extracellular matrix and matrix metalloproteinase genes expression on human annulus fibrosus cells
... the MMP-1 and -3 genes was upregulated in rabbit tendon cells following 1 dyne/cm 2 fluid-induced shear stress for 6 h in a specially designed multi-slide flow device ...
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Clinical evaluation of a matrix metalloproteinase 12 cleaved fragment of titin as a cardiovascular serological biomarker
... The study relied on a well-characterised cohort in which all samples were collected under the same standard operating procedures. The study presents for the first time an assay for in vivo detection of titin degradation ...
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C-1562T polymorphism of matrix metalloproteinase-9 (MMP-9) gene associated with elevated level of plasma MMP-9 concentration in patient with acute myocardial infarction (AMI) in Denpasar-Bali
... Background: Acute Myocardial Infarction (AMI) is an emergency medical condition which still has high mortality and morbidity. In recent decades, its prevalence has a tendency to increase, parallel with other chronic ...
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Immunohistochemical expression of Matrix Metalloproteinase-2 (MMP-2) in inguinal hernia
... as MMP-12 shares its ability to cleave elastin along with other MMPs like gelatinases and ...addition MMP-20 can also degrade tooth enamel, specifically ...
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Matrix metalloproteinase-2, tissue inhibitor of matrix metalloproteinase-2, and transforming growth factor beta 1 in the aqueous humor and serum of patients with pseudoexfoliation syndrome
... the control groups. This finding suggests that these molecules may not be major risk factors for the investigated disease, but they might be the outcomes. According to recent reports, increased oxidative stress and a ...
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<p>MMP-2, MMP-9, TIMP-1, and TIMP-2 in the Peripheral Blood of Patients with Differentiated Thyroid Carcinoma</p>
... extracellular matrix breakdown in breast ...and MMP-9) during human colorectal tumor- ...al. Matrix metalloproteinase (MMPs) expression by differentiated thyroid carcinoma of children and ...
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Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain related molecule expression following tumor necrosis factor α stimulation of synovial cells: an in vitro study
... extracellular matrix-degrading enzymes and pain- related molecules [13 – ...reduced matrix metalloproteinase-3 (MMP-3) ex- pression by IL-1 β ...
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Roles of low-density lipoprotein receptor-related protein 1 in tumors
... regulating matrix metalloproteinase (MMP)-2 and MMP-9 expression and functions but also inhibits cell apoptosis by regulating the insulin receptor, the serine/ threonine protein kinase ...
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Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis
... plasma matrix metalloproteinase (MMP)-3, MMP-9 and tissue inhibitor of metalloproteinases (TIMP)-1 were measured as the biochemical markers of ...
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Original Article Association of MMPs/TIMPs polymorphism with alcohol-induced osteonecrosis of femoral head in the Chinese Han population
... Abstract: Alcohol-induced osteonecrosis of the femoral head (alcohol-induced ONFH) makes up almost one-third of the total proportion of non-traumatic ONFH. Polymorphism of matrix metalloproteinase ...
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Adiponectin is a potential catabolic mediator in osteoarthritis cartilage
... of metalloproteinase (TIMP)-2 and downregulates IL-1b-induced matrix metalloproteinase (MMP)-13 in OA chondrocytes, whereas Lago et ...IL-6, MMP-3, MMP-9, and MCP-1 in murine ...
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Toll like receptor 2 (TLR2) induces migration and invasive mechanisms in rheumatoid arthritis
... Cell migration is essential for tissue infiltration during the inflammatory process and is initiated by cell polar- isation and the formation of membrane protrusions at the leading edge [12]. Integrin-linked activation ...
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Synergistic and protective effect of atorvastatin and amygdalin against histopathological and biochemical alterations in Sprague-Dawley rats with experimental endometriosis
... Oxidative stress plays a crucial role in the pathophysi- ology of endometriosis. Cytokines released from mac- rophages increase cellular redox status (Bedaiwy and Falcone 2003), as evidenced by the higher Gpx and SOD ...
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Curcumin slows osteoarthritis progression and relieves osteoarthritis associated pain symptoms in a post traumatic osteoarthritis mouse model
... Background: Curcumin has been shown to have chondroprotective potential in vitro. However, its effect on disease and symptom modification in osteoarthritis (OA) is largely unknown. This study aimed to determine whether ...
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