Matrix Metalloproteinases
Effect of serum-containing and serum-free culture medium-mediated activation of matrix metalloproteinases on embryonic developmental competence
... of matrix metalloproteinases (MMPs) and tissue inhibitors of metal- loproteinases (TIMPs) in blastocysts produced using serum-free and serum-containing ...
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Expression of Matrix Metalloproteinases and Their Tissue Inhibitor during Viral Encephalitis
... extracellular matrix (ECM) components of the blood brain barrier (BBB) as well as limited parenchymal extracellular spaces (25, ...inflammation, matrix metalloproteinases (MMPs) degrade the basal ...
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Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma
... The matrix degradation in the base- ment membrane is closely related to activities of various subtypes of matrix metalloproteinases (MMPs) and ...
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Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
... extracellular matrix (ECM) metabolism may contribute to vascular remodeling during the development and complication of human atherosclerotic ...of matrix metalloproteinases (MMPs), a family of ...
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Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis
... The concept of TIMP-1 translocating into the nucleus remains controversial [32,33], and the functions of TIMP in this location in vivo remain to be identified. However, as dis- cussed below, several recent studies have ...
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Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis
... sepsis [1,2]. The most common clinical presentation of MD is meningococcal meningitis (MM), which can affect 30-60% of infected patients, with adolescents and young adults being the age group at higher risk [3,4]. MM is ...
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Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis
... Extracellular matrix metalloproteinases (Mmps) regulated by secreted tissue inhibitors of metalloproteinases (Timps), cleave secreted and membrane-associated targets to sculpt the extracellular ...
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The Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Idiopathic Interstitisal Pneumonia
... unclear, matrix metalloproteinases (MMP) and tissue inhibitors of matalloproteinases (TIMP) are known to be important factors that affect the progress of IPF ...
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Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase 1, and matrix metalloproteinase 13 expression in fibroblast like synoviocytes more than proinflammatory mediators
... and matrix metalloproteinases in rheumatoid arthritis fibroblast-like synoviocytes Next, to evaluate whether adiponectin stimulates the produc- tion of VEGF and MMPs for angiogenesis of pannus and joint ...
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Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo
... of metalloproteinases in axon extension and ...metzincin metalloproteinases are zinc-dependent extracellular proteases that are subdivided into four subfamilies based on structure: astacins, serralysins, ...
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Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration
... extracellular matrix (ECM) degradation ...enzymes, matrix metalloproteinases (MMPs) and aggrecanases, and their natural inhibitors, tissue inhibitors of metalloproteinases (TIMPs) ...
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Matrix metalloproteinases in inflammatory bowel disease: an update
... cited. Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings ...
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CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis
... have shown the involvement of CCR9-CCL25 axis in colorectal, prostate, ovarian and breast cancers [7-11]. In patients with breast or ovarian carcinomas, higher CCR9 expression in cancer tissues correlate with disease ...
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Matrix metalloproteinases in arthritic disease
... of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as potential ...
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Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
... Matrix metalloproteinases (MMPs) 9 and 2 are increased in human abdominal aortic aneurysm (AAA) tissue, but their precise role and potential interaction remain ...
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Matrix metalloproteinases in arthritic disease.
... of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as potential ...
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Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases as Plasma Indicators of Bovine Cystic Ovarian Disease
... the matrix metallopro- teinases (MMP) and plasminogen activator/plasmin families of extracellular (ECM) ma- trix-degrading proteinases are involved in Graafian follicle breakdown and oocyte release in the ...
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Expression of CD147 and matrix metalloproteinase 11 in colorectal cancer and their relationship to clinicopathological features
... lular matrix metalloproteinase inducer (EMMPRIN), is a member of the immunoglobulin superfamily of adhesion ...secrete matrix metalloproteinases ...
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Role of Matrix Metalloproteinases in Intestinal Inflammation
... In this model, up-regulation of MMP-9 and MMP-2 has been also shown (Tarlton et al., 2000). Interestingly, in this study, mucosal and epithelial matrix degradation was clearly asso- ciated with infiltrating ...
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Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies
... The activity of MMPs may be also controlled by a series of endogenous inhibitors. Some of them are general protease inhibi- tors such as α 2-macroglobulin, which mainly blocks MMP activity in plasma and tissue fluids, ...
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