Matrix metalloproteinases (MMP)
The role of synovial macrophages and macrophage produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis
... of matrix metalloproteinases (MMPs), tis- sue inhibitors of MMP (TIMPs), and link protein in osteoarthritis synovial cell ...for MMP-1, MMP-3, MMP-13, TIMP-1, TIMP-2, TIMP- 3, ...
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The Significance of Matrix Metalloproteinases in Oral Diseases
... the MMP family has grown to include at least 23 members in humans and 24 in ...13]. Matrix metalloproteinases are considered members of the multigene metzincin family, which also includes ...
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Effect of serum-containing and serum-free culture medium-mediated activation of matrix metalloproteinases on embryonic developmental competence
... of matrix metalloproteinases (MMPs) during embryonic development (Mizumachi et ...extracellular matrix (ECM) during embryonic ...particular, MMP-9 is implicated in the develop- ment of early ...
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The Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Idiopathic Interstitisal Pneumonia
... unclear, matrix metalloproteinases (MMP) and tissue inhibitors of matalloproteinases (TIMP) are known to be important factors that affect the progress of IPF ...
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Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection
... extracellular matrix (ECM) of affected vessel walls. As matrix metalloproteinases (MMP) play a central role in the regulation of the ECM, an increased expression of these enzymes might lead to ...
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Matrix metalloproteinases in exercise and obesity
... Abstract: Matrix metalloproteinases (MMPs) are zinc- and calcium-dependent endoprotein- ases that have the ability to break down extracellular ...particular, MMP-1, -2, and -9 may be associated with ...
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Evaluation of matrix metalloproteinases (MMP)-2 and MMP-9 activity in serum and biochemical and hematological parameters in spontaneous canine cutaneous tumors before and after surgical treatment
... Recently, matrix metalloproteinases (MMP), in particular the gelatinases MMP-2 and MMP- 9, generally considered as tumor markers for clinical ...of MMP-2 and MMP-9 were ...
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Matrix metalloproteinases in inflammatory bowel disease : expression, regulation and clinical relevance
... battle against their unknown targets, these cells may damage the intestinal tissue in various ways. T cell activated neutrophils and macrophages release massive amounts of harmful reactive oxygen metabolites by ...
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Matrix metalloproteinases in pancreatitis: current insights
... processes. Matrix metalloproteinases (MMPs) are an important family of metal ion-dependent enzymes that represent a major class of endopeptidases respon- sible for degradation and remodeling of ECM ...
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Matrix metalloproteinases and epileptogenesis
... Neurons and glial cells secrete diverse molecules that contribute to the composition of the ECM. The quantity of ECM relative to cell mass is very high during em- bryonic development and declines towards the time of ...
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Matrix metalloproteinases in arthritic disease.
... colocalise MMP synthesis with cytokine and matrix expression in synovia from diseased joints in order to explore further the mecha- nisms that control the synthesis and degradation of ECM components of ...
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Matrix metalloproteinases in lung biology
... the MMP knockout mice generated to date (Table ...only MMP involved in repair of airway epithelial ...this MMP leads to excessive bronchiolization [45 • ], suggesting a role in either cell migration ...
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Matrix metalloproteinases in arthritic disease
... which MMP (or which other metallopro- teinase, such as ADAM-TS4/5 with aggrecanase activity) to inhibit still ...broad-spectrum MMP inhibitor that also inhibits the ADAM proteinases ...
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Matrix metalloproteinases-9 (mmp-9) gene polymorphisms in patients with or without family history of myocardial infarction
... between MMP-9 single nucleotide polymorphisms (SNPs) and ...of MMP-9 gene involved in the patho-physiology cardiovascular diseases, including MI and ACS ...The MMP-9 gene polymorphisms (R279Q & ...
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Role of Matrix Metalloproteinases in Intestinal Inflammation
... of MMP-1 and MMP-3, leading to severe tissue damage with epithelial cell shedding and loss of villi, whereas pokeweed mitogen- induced mucosa injury was abolished by CT1399, a synthetic MMP inhibitor ...
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Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases as Plasma Indicators of Bovine Cystic Ovarian Disease
... in MMP-2 plasma concentrations, as evi- denced by the SE associated with the ...of MMP-2 and -9 in plasma and follicular fluid in women with PCOS ...
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Role of matrix metalloproteinases (MMPs) and MMP inhibitors on intracranial aneurysms: a review article
... Tissue remodeling associated with vari- ous physiological and pathological process- es are influenced by MMPs. Example of such processes are: morphogenesis, angio- genesis, apoptosis, tissue injury , cirrhosis, ...
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Matrix metalloproteinases in the mouse retina: a comparative study of expression patterns and MMP antibodies
... in MMP expression and activity levels, rather than determining the spatial localization and function of these ...of MMP expression/activ- ity, extensive regulation of MMPs at transcriptional, translational ...
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Matrix metalloproteinases and their tissue inhibitors after selective laser trabeculoplasty in pseudoexfoliative secondary glaucoma
... After the initial success of selective laser trabeculoplasty treatment with a reduction in IOP of 20% compared with the baseline values, eyes with PEXG-SLT showed a pro- gressive increase in IOP, which, after a mean of ...
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Original Article Bone marrow derived mononuclear stromal cells and experimental model of deep endometriosis
... extracellular matrix, which directly involves the matrix metalloproteinases [33, ...both MMP-1 and MMP-9 present- ed over expression in the cases with endome- triosis [35, ...of ...
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