matrix metalloproteinases (MMPs)
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in the aqueous humour of patients with primary angle closure glaucoma - a quantitative study
... The role of matrix metalloproteinases (MMPs) in de- grading and remodelling extracellular matrix (ECM) is well documented [1,2]. In the eye, abnormal expression of MMPs has been implicated in corneal ...
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Matrix metalloproteinases in cystic fibrosis: pathophysiologic and therapeutic perspectives
... Notes: The left and middle panels show the multiple domains present in subgroups of pro-MMPs. The “cysteine switch” mechanism by which latency is achieved in pro- MMPs is mediated through an interaction between a ...
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MATRIX METALLOPROTEINASES: DO YOU KNOW THEM?
... Matrix Metalloproteinases are expressed in response to specific stimuli by resident connective tissue cells as well as the major inflammatory cell types that invade the tissue during remodeling ...
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The Significance of Matrix Metalloproteinases in Oral Diseases
... 13]. Matrix metalloproteinases are considered members of the multigene metzincin family, which also includes transmembrane and secreted proteins called a dis- integrin and metalloproteinases (ADAMs), ...
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Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration
... extracellular matrix (ECM) degradation ...enzymes, matrix metalloproteinases (MMPs) and aggrecanases, and their natural inhibitors, tissue inhibitors of metalloproteinases (TIMPs) ...
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Matrix metalloproteinases in pancreatitis: current insights
... processes. Matrix metalloproteinases (MMPs) are an important family of metal ion-dependent enzymes that represent a major class of endopeptidases respon- sible for degradation and remodeling of ECM ...
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Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases
... Fig. 1 Quantitative PCR shows gene expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in human non-pigmented ciliary epithelial cells (HNPCECs). MMP-1, ...
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Matrix metalloproteinases in impaired wound healing
... particular matrix metalloproteinases (MMPs) contribute to all phases of the healing process by regulating immune cell influx, facili- tating migration of fibroblasts and keratinocytes, and remodeling of the ...
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Liver transplantation : chimerism, complications and matrix metalloproteinases
... Chimerism after orthotopic liver transplantation (OLT) is the main focus of the studies described in this thesis. The first study showed that chimerism of different cell lineages within the liver graft does occur after ...
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Matrix metalloproteinases in inflammatory bowel disease: an update
... cited. Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings ...
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Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis
... Extracellular matrix metalloproteinases (Mmps) regulated by secreted tissue inhibitors of metalloproteinases (Timps), cleave secreted and membrane-associated targets to sculpt the extracellular ...
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Matrix metalloproteinases in the wound microenvironment: therapeutic perspectives
... Abstract: Matrix metalloproteinases (MMPs) are key effector molecules responsible for extracellular matrix (ECM) turnover. They are involved in tissue remodeling and regeneration. Although the main ...
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Matrix metalloproteinases in head and neck cancer: current perspectives
... Abstract: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases encoded by 24 distinct genes. Their functions have been implicated in numerous normal and pathologic processes, including uterine ...
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ROLE OF MATRIX METALLOPROTEINASES IN THE DEVELOPMENT OF ENDOMETRIOSIS IN WOMEN WITH INFERTILITY
... The activity of matrix metalloproteinases (MMPs) 2, 9 and 11 on ectopic endometrium was studied in women with endometriosis. Fragments of ectopic endometrium (endometriotic tissue), obtained by laparoscopy ...
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Matrix metalloproteinases and their inhibitors in human traumatic spinal cord injury
... extracellular matrix (ECM) plays an important role in most of these events Matrix metalloproteinases (MMPs) are a family of extra- cellular zinc- and calcium-dependent endopeptidases that degrade the ...
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Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma
... The matrix degradation in the base- ment membrane is closely related to activities of various subtypes of matrix metalloproteinases (MMPs) and ...
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The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases
... The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are zinc matrix metalloproteinases (MMPs) with a precisely ordered modular organization. ADAMTS comprises a family of secreted ...
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MATRIX METALLOPROTEINASES AND THEIR ROLE IN BREAST CANCER: A MINI REVIEW
... Matrix metalloproteinases (MMPs) are members of metzincin group of zinc- dependent endopeptidases which are responsible for degrading and remodeling of extracellular matrix (ECM) during ...
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Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis
... The concept of TIMP-1 translocating into the nucleus remains controversial [32,33], and the functions of TIMP in this location in vivo remain to be identified. However, as dis- cussed below, several recent studies have ...
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Matrix metalloproteinases in exercise and obesity
... Abstract: Matrix metalloproteinases (MMPs) are zinc- and calcium-dependent endoprotein- ases that have the ability to break down extracellular matrix. The large range of MMPs’ func- tions widens ...
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