Maturity-Onset Diabetes
Glucose Turnover and Disposal in Maturity Onset Diabetes
... discrepancies may have been due to methodology, and to nonrecognition of a circadian cycle in the glucose turnover rate that is present in health, and marked in diabetes. During the early morning hours the glucose ...
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Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young
... Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor involved in glucose homeostasis and is required for normal β cell function. Mutations in the HNF4α gene are associated with maturity onset ...
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<p>Maturity-onset diabetes of the young (MODY): current perspectives on diagnosis and treatment</p>
... Abstract: Maturity-onset diabetes of the young (MODY) is characterized by autosomal dominant inheritance, onset before 25 years of age, absence of β -cell autoimmunity, and sustained ...
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Studies of genetic variability of the hepatocyte nuclear factor-1α gene in an Indian maturity-onset diabetes of the young family
... Maturity‑onset diabetes of the young (MODY), one of the specific types of diabetes mellitus, is a monogenetic disor‑ der characterized by an autosomal dominant (AD) inheritance and β‑cell ...
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Analysis of the glucokinase gene in Iranian families with maturity onset diabetes of the young
... 2 diabetes identified up to this time (8% to 63%) ...2 diabetes called maturity onset diabetes of the young type 2 (MODY2) ...2 diabetes is char- acterized by mild and stable ...
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Deletion of the donor splice site of intron 4 in the glucokinase gene causes maturity onset diabetes of the young
... Missense and nonsense mutations in the glucokinase gene have recently been shown to result in maturity-onset diabetes of the young (MODY), a subtype of non-insulin-dependent diabetes mellitus ...
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Maturity onset diabetes of the young: Diagnosis and treatment options
... Abstract: Diabetes is a complicated disease, so multiple factors are involved in its ...2 diabetes mellitus have a monogenic form of this disease which has different treatment options and usually fewer ...2 ...
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HNF1A gene p.I27L is associated with early-onset, maturity-onset diabetes of the young-like diabetes in Turkey
... suspected maturity-onset diabetes of the young (MODY) has not been ...MODY-like diabetes mellitus in the Turkish ...MODY-like diabetes (n = 486) and non-diabetic controls (n = 263) were ...
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Evolution- and Structure-Based Computational Strategy Reveals the Impact of Deleterious Missense Mutations on MODY 2 (Maturity-Onset Diabetes of the Young, Type 2)
... of diabetes mellitus is well known, and approximately 347 mil- lion people (WHO Report) suffer from diabetes mellitus ...of diabetes, maturity-onset diabetes of the young (MODY), ...
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Effects of hepatocyte nuclear factor 1A and 4A on pancreatic stone protein/regenerating protein and C reactive protein gene expression: implications for maturity onset diabetes of the young
... Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of non-ketotic, non-insulin dependent diabetes that is typically diagnosed before 25 years of ...1 diabetes, ...
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Genetic and clinical characteristics of Chinese children with Glucokinase-maturity-onset diabetes of the young (GCK-MODY)
... monogenic diabetes genes was designed which comprised 157,624 bp that covered all exons to- gether with the flanking exon and intron boundaries (±15 bp) of 44 genes, including GCK, INS, HNF1A, HNF1B, HNF4A, ...
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Insulin Sensitivity and Insulin Binding to Monocytes in Maturity Onset Diabetes
... Tissue sensitive to insulin and insulin binding to monocytes were evaluated in 15 nonobese maturity-onset diabetics and in 16 healthy controls. Insulin sensitivity was determined by the insulin clamp ...
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Clinical features and treatment of maturity onset diabetes of the young (MODY)
... Although the diagnosis of MODY is rare, and constitutes only a small proportion of the people afflicted with diabetes, it has important implications. For the individual, it informs optimal treatment options in ...
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A missense mutation in hepatocyte nuclear factor 4 alpha, resulting in a reduced transactivation activity, in human late onset non insulin dependent diabetes mellitus
... Non–insulin-dependent diabetes mellitus (NIDDM) is a heterogeneous disorder characterized by hyperglycemia re- sulting from defects in insulin secretion and ...with maturity-onset diabetes of ...
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Genetic evidence that HNF 1α–dependent transcriptional control of HNF 4α is essential for human pancreatic β cell function
... Mutations in the genes encoding hepatocyte nuclear factor 4 α (HNF-4 α ) and HNF-1 α impair insulin secretion and cause maturity onset diabetes of the young (MODY). HNF-4 α is known to be an essen- ...
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Stem cells as a potential therapy for diabetes mellitus: a call-to-action in Latin America
... DM: diabetes mellitus; MODY: maturity-onset diabetes of the young; LADA: latent autoimmune diabetes of the adult; DPP-4: dipeptidyl peptidase IV; SGLT2: sodium-glucose cotransporter 2; ...
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Classification of Diabetes Mellitus
... of diabetes is important because different types of the disease have different ...example, Maturity-Onset Diabetes of Young (MODY3) is often mis-diagnosed as Insulin Dependent Diabetes ...
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New-Onset Diabetes after Transplant (NODAT)
... Starlz was the first to describe the role of corticosteroids in NODAT in 1964 in renal transplant recipients [34]. The diabetogenic effect of glucocorticoids is mainly due to insulin resistance, mediated by both impaired ...
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Diabetes the Global Economic Burden of Adults and the Role of Herbalism as a safe & altenative cost -effective therapy. An Updared Overview
... Afrezza (insulin human) Inhalation Powder was approved by the FDA in June 2014. Afrezza is an ultra-rapid-acting inhaled insulin that is administered with meals to improve glycemic control in adult diabetics. In clinical ...
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Insulin effect on Leptin Concentration in Children with New Onset Insulin Dependent Diabetes Mellitus
... Objective: Serum Leptin concentration reflects the body fat mass. There is controversial reports about the insulin effect on serum Leptin concentration. We wanted to examine the effect of insulin therapy on serum Leptin ...
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