Maximum Tolerated Dose
A comparative study of the estimation of the maximum tolerated dose
... the maximum dose of a new pharmacological treatment with significant effect but that will not cause unacceptable adverse effect; commonly known as the maximum tolerated dose ...using ...
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Ambulatory blood pressure parameters after canrenone addition to existing treatment regimens with maximum tolerated dose of angiotensin-converting enzyme inhibitors/angiotensin II type 1 receptor blockers plus hydrochlorothiazide in uncontrolled hypertensive patients
... the maximum tolerated dose of ACE inhibitors or AT1R antagonists plus HCT) and were randomly assigned to be treated for 3 months with canrenone (50 or 100 mg/day) in addition to their existing ...
8
Platinum Co-ordination Complexes in Cancer Chemotherapy14-19
... platinum(1V) (CHIP, JM9) were reported. The maximum tolerated dose in patients who had received previous chemotherapy with other drugs was 45mg/m2/day. Partial responses we[r] ...
6
ACUTE AD SUB-CHROIC TOXICITY EFFECT OF JASMIUM SAMBAC LI. OLEACEAE FLOWER I SWISS ALBIO MICE
... the maximum tolerated dose) of MEJS was investigated in mice for six weeks and the evaluation was done by the studies of hematological parameters, biochemical estimations of hepatorenal parameters, ...
9
Tolerability of oral sorafenib in pet dogs with a diagnosis of cancer
... one dose of sorafenib and presented 1 week later for a follow-up examination, blood work, and assessment of drug ...a maximum tolerated dose as may be reasonable in conventional cytotoxic ...
6
Pharmacokinetics and safety of DTS-108, a human oligopeptide bound to SN-38 with an esterase-sensitive cross-linker in patients with advanced malignancies: a Phase I study
... CTCv3.1, dose-limiting toxicities at cycle 1, the maximum tolerated dose (MTD), and the recommended Phase II dose (RP2D) of intravenous DTS-108 (1–2 hours) every 2 weeks were evaluated ...
10
Anticholangiocarcinoma activity and toxicity of the Kaempferia galanga Linn Rhizome ethanolic extract
... the maximum single oral dose of 5000 mg/kg body weight and daily dose of 1000 mg/kg body weight for 30 ...the maximum tolerated dose of 1000 mg/kg body weight for 30 days ...
11
Pomalidomide: a novel drug to treat relapsed and refractory multiple myeloma
... pomalidomide dose-level cohorts: 2 mg (n = 6); 3 mg (n = 8); 4 mg (n = 14); and 5 mg (n = ...four dose- limiting toxicities (grade 4 neutropenia) at 5 mg/day, the maximum tolerated dose ...
8
Phase I dose-escalation study of long-acting pasireotide in patients with neuroendocrine tumors
... the maximum tolerated dose (MTD) and characterizing the safety, tolerability, pharmacokinetics (PKs), and efficacy of pasireotide in patients with advanced neuroendocrine tumors ...phases: ...
10
A phase I clinical study of VB4-845: Weekly intratumoral administration of an anti-EpCAM recombinant fusion protein in patients with squamous cell carcinoma of the head and neck
... the maximum tolerated dose (MTD) of VB4-845 when administered as weekly intratumoral (IT) injections to patients with squamous cell carcinoma of the head and neck ...ascending dose cohorts of ...
10
<p>Comparative review of drug–drug interactions with epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer</p>
... the maximum tolerated dose (MTD) of erlotinib in current smokers with NSCLC was 300 mg/day 108 (ie, double the MTD previously established in unselected patients), although the authors did not spec- ...
18
Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency
... the maximum tolerated dose (MTD) and phar- macokinetics of both intravenous (IV) and intra-arterial (IA) NAC in adults with chronic kidney disease to be used in further trials on oto- and ...
10
Results of the safety run-in part of the METAL (METformin in Advanced Lung cancer) study: a multicentre, open-label phase I–II study of metformin with erlotinib in second-line therapy of patients with stage IV non-small-cell lung cancer
... optimal dose of metformin to be used in non-diabetic patients still remains to be ...the maximum tolerated dose and to evaluate safety and activity of metformin combined with erlotinib in ...
6
A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies
... of dose-finding studies in Phase I trial is to estimate maximum tolerated dose (MTD), which is the maximum test dose that can be assigned with an acceptable level of ...
13
The effect of an H2 receptor antagonist on food stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcers: comparison with an anticholinergic drug
... largest dose of isopropamide that can be taken clinically without producing intolerable side effects (maximum tolerated dose) suppressed food-stimulated acid secretion by ...400-mg dose ...
8
Docetaxel-loaded human serum albumin (HSA) nanoparticles: synthesis, characterization, and evaluation
... Methods: In this study, a DTX-loaded human serum albumin (HSA) nanoparticle (DTX-NP) was designed to overcome the hypersensitivity reactions that are induced by polysorbate 80. The methods of preparing the DTX-NPs have ...
14
Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers
... the maximum tolerated dose of ISO in combination with ibuprofen, and the further assessment of the safety of the combined treatment in terms of AEs and variations in ...well tolerated by ...
9
A phase I study of AST1306, a novel irreversible EGFR and HER2 kinase inhibitor, in patients with advanced solid tumors
... DLT: Dose-limiting toxicity; RP2D: Recommended phase II dose; MTD: Maximum tolerated dose; EGFR: Epidermal growth factor receptor; TKI: Tyrosine kinase inhibitor; NSCLC: Non-small-cell ...
11
Phase I study of miriplatin combined with transarterial chemotherapy using CDDP powder in patients with hepatocellular carcinoma
... I dose- escalation study on DDP-H-TAC followed by miriplatin- TOCE to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) in unresect- able ...
8
A Phase Ib study of ruxolitinib + gemcitabine ± nab-paclitaxel in patients with advanced solid tumors
... a dose-finding phase to identify the maximum tolerated dose (MTD) of ruxolitinib when administered with gemcitabine with or without nab-paclitaxel to patients with advanced or meta- static ...
9