MDR1 expression
Influence of RAR α gene on MDR1 expression and P-glycoprotein function in human leukemic cells
... on MDR1 gene activity We studied intrinsic and ATRA induced expression of MDR1 gene in all cell lines by semi-quantitative RT-PCR ...of MDR1 mRNA varied in dif- ferent wild type cells: in H9 ...
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Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after induction chemotherapy
... and MDR1 expression is significantly associated with nodal metastasis independently of a high proliferation rate, which was another of the significant (and independent) predictors identified ...addition, ...
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Original Article Elevated expression of MDR1 associated with Line-1 hypomethylation in esophageal squamous cell carcinoma
... Increased MDR1 expression is an important factor in patients with ...with MDR1 activation may be important for better understanding of Line-1 hypomethyl- ...elevated expression of MDR1 ...
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Transcriptional Regulation of MDR1, Encoding a Drug Efflux Determinant, in Fluconazole-Resistant Candida albicans Strains through an Mcm1p Binding Site
... the MDR1 trans-activation strains CAPR510, CAPR513, CAPR514, CAPR515, and CAPR517 ...affect MDR1 expression, indicating that there was a region(s) upstream of the MDRE that was functionally redundant ...
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Effect of mdr1 gene expression related to c3435t polymorphism in iraqi acute myeloid leukemia patients
... higher MDR1 expression rates in ...high expression in acute leukemia might eliminating the antileukemic drugs (Anthracyclines, Daunorubicin and Vincristeine) (Roa et ...the expression and ...
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P-glycoprotein Mediates Postoperative Peritoneal Adhesion Formation by Enhancing Phosphorylation of the Chloride Channel-3
... of MDR1 expression in ...human MDR1-GFP vectors and ClC-3-Flag or ...P-gp expression or inhibition of Src kinase by SU6656 on phosphorylation of human ClC-3 tyrosine induced by TGF β1 and ...
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Original Article Relationship between the expression of MDR1 in hepatocellular cancer and its biological behaviors
... tance. MDR1 gene encoding P-gp glycoprotein, it is a pharmaceutical carrier can be formed ATP dependent membrane pumps in the cell membrane, and upon binding of anti-cancer drugs can be combined again with the ATP ...
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Significance of MDR1 and multiple drug resistance in refractory human epileptic brain
... of MDR1 expression in drug extrusion by astrocytes To determine whether MDR1 expression in 'epileptic' astrocytes results in enhanced extrusion of xenobiotics compared to 'normal' astrocytes, ...
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Virulence factors, antifungal susceptibility and molecular mechanisms of azole resistance among Candida parapsilosis complex isolates recovered from clinical specimens
... pump MDR1 in only three (out of 35) resistant isolates with a minimum 25-fold increase ...of MDR1 for only one ...mRNA expression of MDR1 in the presence of fluconazole ...However, MDR1 ...
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Association of Acute Lymphoblastic Leukemia and MDR1 Gene Polymorphism in an Ethnic Iranian Population
... P-gp expression in tumor cells is associated with multidrug resistance phenotype in some hematological malignancies, ...of MDR1 gene locus have been ...the expression of ...duodenal MDR1 ...
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ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA
... the expression of genes that are frequently upregulated in HCC, including AFP, GPC3 and H19 [11, ...added MDR1 as a new target of ...represses MDR1 transcription by interacting with NF-YA that is ...
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Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A
... To assess whether the biologic effect of RA on chemo-resistant OS is potentially effective in vivo, we established a nude mouse orthotopic model using chemo-resistant KHOSR cells as described previously [29]. Mice were ...
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Evaluation of biodistribution and safety of adenovirus vector containing MDR1 in mice
... Enhanced BMCs clearance of pharmaceuticals via P-gp may reduce plasma concentrations and in turn the thera- peutic efficacy of these agents. It remained technically feasible that drug resistance gene was able to protect ...
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Effect of benomyl and diazinon on acquired azole resistance in Aspergillus flavus and expression of mdr1 and cyp51c genes
... spergillus flavus, as one of the most common fungal agents widely found in the environment, is one of the most common causes of aspergillosis with a wide clinical manifestation in immunocompromised patients. Azole drugs ...
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Sensitivity of K562 human chronic myelogenous leukemia blast cells transfected with a human multidrug resistance cDNA to cytotoxic drugs and differentiating agents
... the MDR1 gene ...of MDR1 overexpression on cytodestructive and differentiation therapy and the ability of sensitizers to restore chemosensitivity in this ...human MDR1 cDNA from the pHaMDR1/A ...
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Over expression of efflux pumps genes in resistant Candida albicans clinical isolated from oral colonization in Iranian HIV positive patients
... various mechanisms. One of these mechanisms is a point Mutation in the Lanosterol demethylase (ERG11) gene which its product is targeted by azole. The conformational changes induced by the point mutation, unable proper ...
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MDR1/P glycoprotein and MRP 1 mRNA and protein expression in non small cell lung cancer
... of MDR1 or MRP1 gene expression individually – or, in a few cases, both pumps – at either the mRNA or protein level (see Table ...of MDR1 and MRP1 mRNA and protein in the same NSCLC specimens has not ...
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C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance
... P-gp expression and activity and enhanced apoptosis [9], suggesting that c- fos affects the expression of ...of mdr1 and p-gp protein increased ...of mdr1 and p-gp. It indicates that the ...
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<p>Astragalus Polysaccharide Promotes Adriamycin-Induced Apoptosis in Gastric Cancer Cells</p>
... As a result, the purpose of this study was to examine the effects of APS on chemotherapeutic sensitivity of GC to adriamycin and reveal the underlying mechanism. Our results suggested that APS treatment enhanced adriamy- ...
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Pharmacokinetic drug–drug interactions between 1,4-dihydropyridine calcium channel blockers and statins: factors determining interaction strength and relevant clinical risk management
... besylate/atorvastatin calcium combination tablet. C), MDR1 G2677T/A and MDR1 C3435T are determinants of inter-subject vari- ability in fluvastatin pharmacokinetics in healthy Chinese vo[r] ...
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