MDR1 gene
C3435T polymorphism of the MDR1 gene is not associated with blood levels of hypothalamus-pituitary-adrenal axis hormones in healthy male subjects.
... human MDR1 gene has the chromosomal locus 7p21, and has a single nucleotide polymorphism in exon 26 at position 3435 (C3435T, rs1045642) (Hoffmeyer et ...influences MDR1 expression and activity ...
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Effect of mdr1 gene expression related to c3435t polymorphism in iraqi acute myeloid leukemia patients
... AML. MDR1 expression and P-glycoprotein (P-gp) function have been affected by Allelic variants in healthy volunteers (Sipeky et ...that MDR1 gene polymorphism associated with susceptibility to ...
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Association of Acute Lymphoblastic Leukemia and MDR1 Gene Polymorphism in an Ethnic Iranian Population
... the MDR1 gene using the specific primers resulted in a 206 bp DNA ...between MDR1 gene C3435T polymorphism and clinical parameters including age at the time of diagnosis and sex ...
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Original Article C3435T polymorphism in the MDR1 gene and breast cancer risk in northeastern Mexico
... resistance gene 1 (MDR1) encodes a membrane-bound phosphoglycoprotein ...of MDR1 has been investigated for its association with breast cancer in different ...the MDR1 C3435T polymorphism and ...
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IDENTIFICATION OF FUNCTIONAL SNPs OF MDR1 GENE AMONG NEPHROTIC SYNDROME CHILDREN IN SOUTH INDIA
... resistance gene-1 (MDR-1) plays a vital role among NS patients as well as other ...The gene which encodes for a transmembrane P-glycoprotein (P-gp), with 170 kD belonging to the superfamily of ATP-binding ...
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Influence of RAR α gene on MDR1 expression and P-glycoprotein function in human leukemic cells
... of MDR1 gene in some cultured cells of solid tumors ...of MDR1/Pgp activity remains ...influence MDR1 and/or Pgp activity, while in the others it either augmented or reduced MDR1/Pgp ...
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Reversal of multidrug resistance by magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticle copolymerizating daunorubicin and MDR1 shRNA expression vector in leukemia cells
... the MDR1 gene product, P-glycoprotein (P-gp), a 170-kD energy-depen- dent efflux ...and MDR1 shRNA expression vector in K562/A02 ...of MDR1 mRNA. PGC silencer-U6-neo-GFP-shRNA/MDR1 ...
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A robust and versatile signal-on fluorescence sensing strategy based on SYBR Green I dye and graphene oxide
... Optimization of SGI concentration in the detection system was investigated. A 200 µ L MDR1 gene detection system was used to analyze the changes in F/F 0 for different SGI con- centrations. Figure 4 reveals ...
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Original Article Individual postoperative analgesia and gene polymorphisms of CYP3A7 and MDR1: an association study
... and gene polymorphisms of CYP3A7 and ...and MDR1 were analyzed with PCR and ...and MDR1, and was verified by pain scoring for fentanyl ...of gene polymorphisms (P < ...of MDR1 ...
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Multi-drug resistance 1 genetic polymorphism and prediction of chemotherapy response in Hodgkin's Lymphoma
... cells. MDR1 protein, called P-glycoprotein (P-gp), belongs to ATP-binding cassette superfamily ...the MDR1 gene were found to be of clinical importance, since they can alter drug absorption, ...
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Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1)
... LV.SFFV.CDD gene-modified cells was analyzed in the presence of increasing concentrations of ...CTX-R gene was ...LV.SFFV.CDD.2A.MDR1 gene-modified cells demonstrated a marked drug resistance ...
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Sensitivity of K562 human chronic myelogenous leukemia blast cells transfected with a human multidrug resistance cDNA to cytotoxic drugs and differentiating agents
... the MDR1 gene ...of MDR1 overexpression on cytodestructive and differentiation therapy and the ability of sensitizers to restore chemosensitivity in this ...human MDR1 cDNA from the pHaMDR1/A ...
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MDR1polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients
... ( MDR1 ) gene, also known as adenosine triphosphate-binding cassette superfamily member 1 ( ABCB1 ) is an interesting candi- date gene for IBD for several ...reasons. MDR1 encodes a ...
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Functional study of the novel multidrug resistance gene HA117 and its comparison to multidrug resistance gene 1
... HA117 gene and the green fluorescence protein gene (GFP) (Ad-GFP-HA117), the MDR1 and GFP (Ad-GFP-MDR1) or GFP (Ad-GFP) was respectively carried ...HA117 gene and MDR1 ...
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Pharmacogenetics in inflammatory bowel disease: understanding treatment response and personalizing therapeutic strategies
... (MDR1) gene code for a drug efflux pump P-glycoprotein-170 (perme- ability glycoprotein or Pgp), which is expressed on the apical surface of lymphocytes and intestinal epithelial ...
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Ultrasound microbubble-mediated delivery of the siRNAs targeting MDR1 reduces drug resistance of yolk sac carcinoma L2 cells
... resistance gene (MDR1), multidrug resistance-associated protein, lung resistance protein, glutathione-S-transferase Pi, contribute to drug resistance ...that MDR1 was the most and highest expressed ...
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Disruption of the PfPK7 Gene Impairs Schizogony and Sporogony in the Human Malaria Parasite Plasmodium falciparum
... FIG. 1. Gene disruption and genotyping. (A) Disruption of the PfPK7 locus. Primers used for the detection of integration events are indicated by numbered arrows (see Materials and Methods for the primer ...
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Genetic Polymorphisms of Hepatic ABC Transporter in Patients with Hepatocellular Carcinoma
... luciferase gene re- porter experiment indicated that promoter constructs in- cluding -15281_-15278CTCT > delete were not associ- ated with changes in luciferase activity ...
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Pharmacokinetic drug–drug interactions between 1,4-dihydropyridine calcium channel blockers and statins: factors determining interaction strength and relevant clinical risk management
... are also dependent on ABCB1 (adenosine triphosphate [ATP]- binding cassette transporter subfamily B member 1) (the gene coding P-gp) polymorphism. Lercanidipine might inhibit P-gp activity and thus elevate the ...
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Differential drug resistance acquisition to doxorubicin and paclitaxel in breast cancer cells
... Among the ABC transporters, P-glycoprotein (P-gp) is the first described and most extensively studied one [4]. This transporter protein is encoded by the gene multi-drug resistance 1 (MDR1) in human and is ...
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