Mechanotransduction and response
The involvement of interleukin 1 and interleukin 4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration
... cell mechanotransduction following ...chondrocyte mechanotransduction, where the pretreatment of cells with neutralising antibodies to IL-1 b prevented the CTS-induced depolarisation response, ...
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Cellular Mechanotransduction in Bone
... This thesis examined the sensitivity o f cells o f the osteoblastic lineage to mechanical strain using three different methods. First, Atomic Force Microscopy (AFM) was used to mechanically stimulate the cells and ...
267
Molecular mechanisms of mechanotransduction in psoriasis
... Putative treatment strategies against psoriasis Current treatments include conventional therapies with adverse effects and a short-term remission of symptoms, but also targeted therapy with monoclonal antibodies and a ...
11
Mechanotransduction at cell-cell contacts
... However, besides vinculin recruitment, other force-dependent molecular remodeling at cadherin adhesions could also alter local junction mechanics. Additionally, the molecular basis of the stiffening response ...
136
Mechanotransduction: use the force(s)
... same across many different taxa and adhesive pad designs: climbing animals use shear forces (pulling and pushing) to turn adhesion on and off [111, 112]. A pull towards the body typically brings the pad into contact and ...
14
Biophysical Tools to Study Cellular Mechanotransduction
... of Mechanotransduction The phenomenon of mechanotransduction ensures a rapid biochemical response to external mechanical ...in response to a specific mechanical ...
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Biomimetic substrate control of cellular mechanotransduction
... cellular mechanotransduction pathways via allowing easiness in imaging and RNA and protein sample collection, tests on simple flat surfaces would not necessarily recapitulate complex cellular mechanosensing ...
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Inhibition of somatosensory mechanotransduction by Annexin A6
... We next assessed whether overexpressing annexin A6 in DRG neurons had the opposite effect on mechanotransduction to that induced by knocking out Anxa6. Cultured DRG neurons were transfected with a CMV-driven ...
34
YAP-mediated mechanotransduction promotes fibrotic activity
... YAP mechanotransduction which is required for basal expression of pro-fibrotic genes, then YAP activation may be required for the ability of TGFβ1 signalling to induce gene ...
91
Gamma-Sarcoglycan Mediated Mechanotransduction in Skeletal Muscle
... in response to tetanic muscle contraction (Martineau and Gardiner, 2001; Ryder et ...in response to ex vivo mechanical stimulation (Barton, 2006), indicating potential misregulation of its target ...
148
Microfluidic traction force microscopy to study mechanotransduction in angiogenesis.
... study mechanotransduction in ...the response of endothelial cells to mechanical signals could reveal an optimal angiogenic mechanical environment, and provide insight into development, wound healing, the ...
25
Mechanotransduction in Living Bone: Effects of the Keap1-Nrf2 Pathway
... 1.7.6 Research Goals Previous findings indicate that Nrf2 activation increases bone formation. The majority of research in this field, however, has used global knockout models of Nrf2 deficiency [1]. The goals of this ...
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A theoretical model of inflammation and mechanotransduction driven asthmatic airway remodelling
... Abstract Inflammation, airway hyper-responsiveness and airway remodelling are well-established hallmarks of asthma, but their inter-relationships remain elusive. In order to obtain a better understanding of their ...
20
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
... In addition to the direct effect of nuclear rupture, altered nuclear mechanics can affect cells through impaired nuclear mechanotransduction. Recent studies have reported desmin intermediate filament–mediated ...
10
The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate
... Various studies have pointed to the role of mechanical loading in directing MSC fate, and recently the focus has been targeting the LINC complex as a key component of such phenomena. For example, in a study by Uzer et ...
12
The imperative for controlled mechanical stresses in unraveling cellular mechanisms of mechanotransduction
... Cell perfusion chambers have been developed to simulate physiologic fluid flow in vitro and to study the role of fluid flow in mechanotransduction [19,20,22,23,46]. How- ever, this study evaluates how well these ...
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Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy.
... vascular mechanotransduction to shear stress and tensile stress relies on the integrity of cytoskeletal proteins and intercellular communications 12-17 ...in response to vasoactive agents and mechanical ...
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Mechanotransduction of subcellular AMPK and its role in breast cancer cell migration
... We identified the metabolic regulator AMPK as a potential downstream target of FAK/Src signaling in response to fluid shear stress. In our study, interstitial fluid flow induced differential, subcellular AMPK ...
54
Formation, contraction, and mechanotransduction of myofribrils in cardiac development: clues from genetics
... Subsequently, we and others have shown that mutations in other genes that encode other myofibrillar proteins can cause defective cardiac development [5–10]. Traditionally, com- promised contractility of the cardiac ...
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P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction
... in response to fluid shear stress exerted by the flowing ...several mechanotransduction signaling processes that are involved in fluid shear stress–induced endothelial effects, but how fluid shear stress ...
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