MEK/ERK
Cooperation of FGF/MEK/ERK and Wnt/β-catenin pathway regulators to promote the proliferation and pluripotency of mouse embryonic stem cells in serum- and feeder-free conditions
... To gain a deeper understanding of the interaction between FGF/MEK/ERK pathway and Wnt/β-catenin pathway on mESCs proliferation and pluripotency, the regulators of these 2 pathways were used alone and in ...
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RAP1 mediated MEK/ERK pathway defects in Kabuki syndrome
... observed in Rap1a-KO mice (42). These observations are in line with the increased susceptibility to upper airway tract and middle ear infections as well as different levels of immune deficiencies or autoimmune challenges ...
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CVB3 Nonstructural 2A Protein Modulates SREBP1a Signaling via the MEK/ERK Pathway
... the MEK/ERK pathway ...of ERK in our experiments. However, it was shown that three MEK inhibitors (U0126, PD184352, and Trametinib) could block the phosphorylation of ERK significantly ...
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Egr 1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFα induced MEK/ERK signalling
... that MEK/ERK may selectively be required for TNF-modulated proteinase and cartilage ECM transcripts, but not for inflam- matory gene ...that MEK/ERK inhibitors might be used to block the ...
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Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer
... kinase MEK was markedly suppressed, particularly the MEK2 isoform, followed by impaired ERK1/2 phosphorylation and a simultaneous decrease in ERK1/2 protein levels (Figure ...of MEK/ ERK signaling ...
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A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets
... A number of different transcription factor families, including the Ets family, have been implicated in epithelial mesenchymal transitions and cell migrations (Savagner, 2001). In vertebrates, ets1 and ets2 are expressed ...
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Original Article Study on inhibitory effect of paclitaxel on MEK and ERK protein overexpression and activation in different breast cancer cell lines
... 1/2, ERK)pathway is one of the most widely and thoroughly studied MAPK signal transduc- tion pathways thus ...of MEK, ERK of different breast cancer ...of MEK/ERK protein, but paclitax- ...
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Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway
... Fragile X syndrome (FXS) is a monogenic disease that is associated with the expansion of the CGG trinucleotide repeat in the Fragile X mental retardation-1 (FMR1) gene, resulting in a failure to express the Fragile X ...
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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
... The “tumor microenvironment” most likely plays critical roles in CIC survival and also reemergence and subsequent metastasis [206-211]. Combinations of cytotoxic chemotherapeutic drugs and inhibitors which target the ...
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HER2 induces cell proliferation and invasion of non-small-cell lung cancer by upregulating COX-2 expression via MEK/ERK signaling pathway
... In conclusion, our results establish a functional link between HER2 and COX-2 expression in NSCLC, demonstrating that COX-2 is mediated by HER2-mediated MEK/ERK, which subsequently affect cell proliferation ...
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Original Article Trichostatin A promotes bladder cancer cell apoptosis and inhibits cell autophagy through MEK/ERK signaling pathway
... The present studies showed that the mecha- nisms of autophagy-related tumor protective effect may be attributed to the following fac- tors. Autophagy can make tumor cells adapt to the hypoxia microenvironment: Degenhardt ...
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Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy
... the MEK/ERK MAPK signaling pathway has been shown to be essential for EV71 replication in embryonic rhabdomyosarcoma (RD) cells [4, 5], human embryonic kidney (HEK) 293 cells [4], SK-N-SH cells [6] and ...
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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
... dual inhibitors this becomes a realistic therapeutic option. Also in some cases it may be necessary to eliminate the cancer by treatment with a dual PI3K/mTOR inhibitor as well as with an additional PI3K inhibitor which ...
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Computational Modelling, Synthesis and Biological Evaluation of Guanidinium like Derivatives as Protein Kinase Inhibitors for the Treatment of Cancer
... The mechanism of acquired self-sufficiency in growth signals derives from alterations of components in the downstream signalling circuits of the cell which receive signals generated by trans-membrane receptors at the ...
362
umi-unc-2281.pdf
... of ERK activation in patients with EGFR mutations, K-Ras mutations, and who were wild-type for these molecular ...the ERK signaling pathway in ...that ERK-targeted therapies will be an effective ...
231
Epiregulin as a therapeutic target in non-small-cell lung cancer
... to activate multiple downstream signaling pathways, includ- ing the MEK/ERK and PI3K/Akt pathways through an autocrine loop mechanism (Figure 2). Thus, EREG is likely to play diverse oncogenic roles, ...
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Modulation of Gq-Rho Signaling by the ERK MAPK Pathway Controls Locomotion in Caenorhabditis elegans
... KSR-Raf-MEK- ERK signaling be activated? Normally, active Ras recruits Raf to the plasma membrane but it has been shown that artificial recruitment of Raf to the plasma membrane in the absence of Ras is ...
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<p>Natural gypenosides: targeting cancer through different molecular pathways</p>
... Ras-Raf-MEK- ERK pathway, possesses several cascades and is mostly deregulated in human ...MAPK/ ERK pathway molecules are activated through its phos- ...When ERK is activated, it enters the ...
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Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression
... the MEK-ERK- CREB axis, which subsequently up-regulates ...the MEK/ERK pathway in 14-3-3ζ-overexpressing hMEC-derived ...the MEK/ERK pathway could be an effective strategy for ...
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Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity
... Loss-of-function MCT-1 decreases Shc protein levels that presumably work through either by epigenetic modification or by post-transcriptional modulation involving MCT-1 activity. In the former case, Shc promoter function ...
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