Melanoma Cells
Original Article Targeting STAT3 restores BRAF inhibitor sensitivity through miR-759-3p in human cutaneous melanoma cells
... of melanoma and advance the basis upon which such resistance may be ...melanomas cells in vitro and in ...vemurafenib-resistant cells. This suggests that STAT3 plays a role in a subset of ...
11
IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens
... a melanoma cDNA library in search for the antigens recognized by tumor infiltrating T lymphocytes from a melanoma patient ...into melanoma cells [10], we wondered whether other ORFs closer to ...
10
The c-Jun/RHOB/AKT pathway confers resistance of BRAF -mutant melanoma cells to MAPK inhibitors
... BRAF-mutant melanoma patients to BRAF inhibitors is dramatically impaired by secondary resistances and rapid ...BRAF-mutant melanoma cells, inhibition of BRAF or its target MEK induces RHOB ...
15
miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy
... of melanoma cells in vitro and lung colonization in ...of melanoma cells which was reversed by ...supports melanoma progression and suppresses p53-mediated apoptosis pathways, autophagy ...
15
A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme
... target cells were co-incubated overnight with effector cells at different E:T ratios in a 96- well ...target cells were preincubated for 1 h on ice with different concentrations of antiHuman ICAM1 ...
17
Polyphenols from green tea inhibit the growth of melanoma cells through inhibition of class I histone deacetylases and induction of DNA damage
... on melanoma cancer cell growth and the molecular mechanism underlying these effects using different human melanoma cell lines as an in vitro ...of melanoma cell lines (A375, Hs294t, SK-Mel28 and ...
13
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells
... metastatic melanoma tissues than in normal skin, cutaneous squamous cell carcinoma or basal cell ...carcinoma. Melanoma cells overexpressing UBE3C frequently exhibited a mesenchymal phenotype, ...
9
The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells
... A375 melanoma cells takes place within minutes after ...dividing cells in a matter of several hours or days [46, ...cancer cells by either plasma membrane attack via pore formation or through ...
14
Uptake of Cystatin by Melanoma Cells in Culture
... B16F10 melanoma cells were seeded on acidpre-treated glass coverslips ...onto cells on coverslips and incubation followed for 1 hour at 37˚C under cell culture ...The cells were then washed 3× ...
6
Reprogramming of melanoma cells by embryonic microenvironments
... stem cells, such as plasticity and undifferentiated phenotype, are regulated, at least partially, by common ...human melanoma cells by the embryonic microenvironment using zebrafish and chick embryos ...
6
B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells
... of melanoma cells does not lead to cross- resistance to TMZ and ...pulse-treated cells in vitro while not influencing the MGMT promoter methylation status in tumors following ...
14
Retrovirus Targeting by Tropism Restriction to Melanoma Cells
... molecular-weight melanoma-associated antigen (HMW-MAA) to the amphotropic murine leukemia virus ...HMW-MAA-expressing cells, as inclusion of the proline-rich hinge prevented viral binding to the amphotropic ...
7
Mitochondrial oxidative phosphorylation controls cancer cell’s life and death decisions upon exposure to MAPK inhibitors
... cancer cells and their long-term efficacy is strikingly limited in patients with BRAF-mutant ...in melanoma exposed to ...in cells exposed to BRAFi in vitro and in ...NRAS-mutant melanoma ...
13
Original Article Desmoplastic melanoma involving head and fingers: diagnostic challenges and clinical characteristics
... In conclusion, DM is considered a relatively rare variant of malignant melanoma, which mainly consisted of spindle shaped melanoma cells with abundant collagenous matrix, with a high potential ...
8
PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas
... example, cells harboring BRCA1/2 inactivating mutations are sensitive to PARP1 inhibitors [14, ...in melanoma treatment) was effective against melanoma cells displaying downregulation of LIG4 ...
10
Original Article ZFX-mediated down-regulation of FBP1 confers to growth in melanoma
... stem cells and hematopoietic stem cells [16, ...in melanoma cells, the exact biological role and detailed mechanisms remain to be explored in our fur- ther ...
9
Original Article Repression of M-phase phosphoprotein 8 inhibits melanoma growth and metastasis in vitro and in vivo
... Next we determined the role of MPP8 knock- down on cell cycle distribution in melanoma cells. A375 cells transfected with MPP8-shRNA or scramble shRNA were subjected to flow cytometry analysis. We ...
7
Receptor tyrosine kinases and their activation in melanoma
... Figure 1. Summary of signalling pathways from RTKs, with emphasis on those with known importance in melanoma cells. Arrows: upregulation; T-bars: downregulation. Red indicates pro-tumorigenic signaling and ...
33
Healthy mitochondria inhibit the metastatic melanoma in lungs
... tumor cells, distancing themselves from an oxygen supply and avoiding cell apoptosis dominated by mitochondria in hypoxic ...in melanoma cells are altered, and the cells exhibit increased ...
12
Inhibition of Pannexin 1 reduces tumorigenic properties of human melanoma
... biopsies and primary melanoma cells. Although patient-dependent differences should be considered, this expression suggests that PANX1 channel blockers could be applied at each stage of melanoma ...
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