membrane interactions
Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils
... amyloid-protein interactions with cellular membranes have been the focus of intense experimental work in recent years ...and membrane-interactions of misfolded proteins appear to be closely related ...
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Membrane interactions of S100A12 (Calgranulin C)
... peripheral membrane protein with two EF-hand structural ...and membrane models simultaneously? (3) what are the specific conformational changes taking place when ions and membranes are both present? (4) ...
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Spectroscopic Studies of Peptide-Membrane Interactions
... Peptide-membrane interactions play a key role in many biological activities and ...cell membrane (Dathe and Wieprecht, 1999; Sato and Feix, ...the membrane lipids to peptide ...the ...
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Deconstructing the DGAT1 enzyme: membrane interactions at substrate binding sites
... trans- membrane domain, suggesting it would interact with DAG headgroup on (or close to) the membrane surface [17, ...the membrane, in order to access and present the substrates to the catalytic ...
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CapZ-lipid membrane interactions: a computer analysis
... the physiological situation of 0.3–1.5%, which then allows it to associate with the plasma membrane [18]. Furthermore, it has been reported that polyphosphoi- nositides (PPI) form aggregates within the bilayer ...
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Characterization of Hepatitis C Virus Core Protein Multimerization and Membrane Envelopment: Revelation of a Cascade of Core-Membrane Interactions
... Coexpression of the 191 core with exogenous SPP. To con- firm that processing of the signal sequence by SPP is required for core envelopment, the 191 core was coexpressed with the WT or D219A mutant SPP, both of which ...
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Multiscale Simulations Suggest a Mechanism for the Association of the Dok7 PH Domain with PIP-Containing Membranes
... peripheral membrane protein that is associated with the MuSK receptor tyrosine ...the membrane remains largely ...via interactions of the β 1/ β 2, β 3/ β 4, and β 5/ β 6 loops, which together form a ...
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García Soriano, Daniela Azucena (2018): Towards bottom-up reconstitution of a minimal division machinery: characterization of FtsZ chimera protein in different membrane systems. Dissertation, LMU München: Fakultät für Physik
... Small unilamellar vesicles (SUV) are a very frequent starting material for SLB produc- tion. Incubated on a hydrophilic surface (glass, mica or silica), SUV are forced to fuse on a glass coverslip aided by the use of Ca ...
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Applications of neutron reflectometry in biology
... the interactions between these two biomolecules. In fact, protein-membrane interactions are of general great interest; they are at the basis of many diseases (including some of high societal impact ...
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Membranes: A Variety of Energy Landscapes for Many Transfer Opportunities
... The two-fluid formalism is based on the application of the momentum and the mass balances on the dispersed phase and on the fluid phase (Jackson, 1997). This formalism allows to account for the different transport ...
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Biochemical Characterization of Rous Sarcoma Virus MA Protein Interaction with Membranes
... for membrane association and ...localization, membrane binding, and particle release identified specific regions within MA, in addition to the myristate moiety, that are critical for plasma membrane ...
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The NS1 Protein of Influenza A Virus Participates in Necroptosis by Interacting with MLKL and Increasing Its Oligomerization and Membrane Translocation
... in membrane translocation and oligomerization of MLKL, respectively ...and membrane translocation are hallmarks of the necroptosis pathway; however, the underlying mechanisms regulating these events are not ...
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Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B
... and it displayed a complex spectrum with two large negative bands around 208 and 222 nm, indicating the presence of an ␣ -helix with some less-defined secondary structures (Fig. 4A). An ␣ -helix content of approximately ...
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Alcohol reversibly disrupts TNF-α/TACE interactions in the cell membrane
... TNF/TACE interactions by an activity which is reversible and related to alcohol-chain ...cell membrane in a reversible fashion, resulting in inhibition of interactions between TNF- α and ...
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Analyses of Coronavirus Assembly Interactions with Interspecies Membrane and Nucleocapsid Protein Chimeras
... essential interactions with M that map to parts of N protein other than ...reported interactions remains to be determined, but our results establish that they are not required for virion ...
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An Alphavirus E2 Membrane Proximal Domain Promotes Envelope Protein Lateral Interactions and Virus Budding
... virus membrane is covered by a lattice composed of 80 spikes, each a trimer of heterodimers of the E2 and E1 transmembrane ...virus membrane with the endosome membrane, thus initiating virus in- ...
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Characterization of the Mycoplasma pulmonis soluble hemolysin
... In order to understand the role of host defenses in mycoplasmal disease, one must identify the membrane antigens or proteins responsible for the interactions observed and define the mech[r] ...
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Protein and Lipid Interactions Driving Molecular Mechanisms of in meso Crystallization
... the membrane proteins partition into a lamellar phase formed of stacked bilayers and connected to the ...the membrane plane and stacking interactions in the third dimension, perpendicular to the ...
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Alterations in the MA and NC Domains Modulate Phosphoinositide-Dependent Plasma Membrane Localization of the Rous Sarcoma Virus Gag Protein
... dependent membrane localization. (A) Schematic diagrams of RSV Gag ⌬ NC- YFP, which has deletion of amino acids 495 to 577 in the NC domain, and RSV Gag.Zip-GFP, which has the leucine zipper domain of the human ...
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Refined Agent Model Using Shape Based Grained Structure: Application to Membrane Molecules
... Computational performances are often the main drawback for MAS. The needs to implement thousands of agents and the multiple direct interactions between agents re- main the main cost in computing time, comparing ...
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