membrane type-1 matrix metalloproteinase
mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization
... formin 1 (mDia1) expression has been linked with progression of malignant cancers in various ...of membrane type 1-matrix metalloproteinase (MT1-MMP) through interaction with ...
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Original Article Membrane type 1 matrix metalloproteinase expression correlated with the clinicopathological feature and invasion and metastasis in oral squamous cell carcinoma
... of membrane type 1 matrix metalloproteinase (MT1-MMP) in oral squamous cell carcinoma (OSCC) and its correlations with clinicopathologic characteristic, and to further identify the ...
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Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution
... tion. MT1-MMP, for example, has various functions that include the degradation of several types of collagen, the activations of other MMPs and activities related to apop- tosis. This study showed that the expression ...
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High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2)
... β 1 integrin expression suppressed Col I- induced MMP-2 activation via MT1-MMP up-regulation In MCF-7-MT1 cells, Col I caused activation of MMP- 2 despite MT1-MMP being under the control of a heterologous ...
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The Cytoplasmic Domain of Membrane-type 1 Matrix Metalloproteinase is Required for its Survival-Promoting, but not its Migration-Promoting Function in MCF-7 Breast Cancer Cells
... This sort of distinct change in cell morphology was observed in this study upon cytoplasmic domain mutation to MT1-MMP, as cells developed protrusive cell extensions in MT1-MMP stable cell lines cultured in a 3D Matrigel ...
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Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180.
... lacking the collagen-binding domain (East et al., 2003) or empty vector (Fig. 4F). Importantly, expression in Endo180-siRNA- treated cells of wild-type murine Endo180, but not the non- collagen-binding Endo180 ...
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The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane type matrix metalloproteinase 1 and cyclooxygenase 2 expression
... Hepatocellular carcinoma is strongly associated with chronic infection by the hepatitis B virus (HBV) and has poor prognosis due to intrahepatic metastasis. HBx is often the only HBV protein detected in hepatic tumor ...
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Original Article Immunohistochemical expression of matrix metalloproteinase-9 and inhibitor of matrix metalloproteinase-1 in prostate adenocarcinoma
... Collagen type IV is a major component of the basal membrane of the epithelial cells; it has been also detected in the wall of blood vessels and connective ...collagen type IV was detected along the ...
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www.ijcep.com /IJCEP1005007 Case Report Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane
... basement membrane and proteolysis of the extracellular matrix. MMP-1 is the only enzyme able to initiate the breakdown of the interstitial collagens, such as collagen type 1, collagen ...
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A new role of the membrane type matrix metalloproteinase 16 (MMP16/MT3 MMP) in neural crest cell migration
... Fig. 1. MMP16 is expressed in neural crest cells (A) RT-PCR analysis on mRNAs purified from whole embryos of 10, 16, 25 somites (a) or from neural- tube explants obtained from hindbrain levels of 5-8ss embryos (b), ...
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Matrix Metalloproteinase 9 Expression Is Induced by Epstein-Barr Virus Latent Membrane Protein 1 C-Terminal Activation Regions 1 and 2
... 92-kDa type IV collagenase or gelatinase, matrix metalloproteinase 9 (MMP-9), which mediates the degradation of the basement membrane and extracellular ...latent membrane protein ...
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Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study
... in type 2 diabetic patients, high interstitial MMP-3 mRNA expression was associated with higher degrees of inter- stitial injury ...that type IV collagen, one of the major substrates of proteolysis by ...
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Matrix Metalloproteinase-2 as Potential Marker of Early Nephropathy in Type 1 Diabetes
... mesangium matrix and thickening of basement membrane within the ...of type IV collagen and laminin, major components of ECM proteins ...in type 1 ...
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The effect of tomato juice on the expression of matrix metalloproteinase-2 (MMP-2) and type-1 collagen on the vaginal wall of the menopausal rats
... This was a true experimental study using Sprague- Dawley rats. The research material was tomatoes fruits (Solanum lycopersicum) which had been certified by the Indonesian Institute of Sciences, Plant Conservation Center, ...
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Original Article Serum levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 have clinical significance for the evaluation of the prognosis of patients with ruptured intracranial aneurysms after interventional therapy
... of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) before and after interventional therapy of ruptured intracranial aneurysm (IA), as well as their correlation with ...
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Soluble membrane type 3 matrix metalloprioteinase causes changes in gene expression and increased gelatinase activity during Xenopus laevis development
... Injected embryos with gastrulation and neurulation defects further continued to develop with phenotypes that ranged from minor axis perturbation and kinks, to the severe lack of axial structures. At stage 28 (Figure ...
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Interstitial collagenase (matrix metalloproteinase 1) expresses serpinase activity
... that matrix metalloproteinase-1 displays an expanded substrate repertoire that supports the existence of a new interface between connective tissue turnover and Serpin ...
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Differential membrane binding of the human immunodeficiency virus type 1 matrix protein.
... wild- type b -Gal was mostly localized to the soluble fraction ...N-terminal membrane binding signal but not the last a helix of p17MA, all exhibited association with the membrane fractions ...of ...
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Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1
... MMP activity in MAV-1-infected pmBECs. We investigated which cell types in the neurovascular unit produce MMP activity and how the MMP activity changes after MAV-1 infection. MAV-1 infects ...
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Serum Matrix Metalloproteinase 3 and Tissue Inhibitor Metalloproteinase 1 in Vascular Dementia: A Comparative Study
... Regarding MMP3 studies has demonstrated that serum MMP3 level is significantly increased at acute stage of large artery atherosclerosis as well as small artery occlusion type strokes [15]. In addition An ...
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