membrane-type matrix metalloproteinase
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane type matrix metalloproteinase 1 and cyclooxygenase 2 expression
... Hepatocellular carcinoma is strongly associated with chronic infection by the hepatitis B virus (HBV) and has poor prognosis due to intrahepatic metastasis. HBx is often the only HBV protein detected in hepatic tumor ...
9
A new role of the membrane type matrix metalloproteinase 16 (MMP16/MT3 MMP) in neural crest cell migration
... that matrix remodeling enzymes are involved (Bar et ...2000). Matrix-metalloproteinases (MMPs) are a family of secreted or membrane bound enzymes, known primarily for their ability to degrade a wide ...
13
Original Article Membrane type 1 matrix metalloproteinase expression correlated with the clinicopathological feature and invasion and metastasis in oral squamous cell carcinoma
... of membrane type 1 matrix metalloproteinase (MT1-MMP) in oral squamous cell carcinoma (OSCC) and its correlations with clinicopathologic characteristic, and to further identify the function of ...
13
Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1
... adenovirus type 1 (MAV-1) infection causes encephalitis in sus- ceptible strains of mice and alters the permeability of infected brains to small mole- cules, which indicates disruption of the blood-brain barrier ...
16
Matrix Metalloproteinase-2 as Potential Marker of Early Nephropathy in Type 1 Diabetes
... mesangium matrix and thickening of basement membrane within the ...of type IV collagen and laminin, major components of ECM proteins ...in type 1 ...
5
Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution
... crude membrane fraction from the rat uterus was iso- lated as previously reported ...crude membrane fraction and stored at -80°C until ...of membrane-bound pro-MMP-2, aliquots of the crude uter- ine ...
7
Original Article Immunohistochemical expression of matrix metalloproteinase-9 and inhibitor of matrix metalloproteinase-1 in prostate adenocarcinoma
... the type IV collagen in the basement membrane of the prostatic glands was evaluated semi-quan- titatively in compliance with the following parameters 0-lack of collagen along the base- ment membrane, ...
9
Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes
... cell membrane forms is mediated by certain members of the ADAM [a disintegrin and metalloproteinase] proteinase family ...the matrix metalloproteinases [MMP], which have a role in vascular plaque ...
5
www.ijcep.com /IJCEP1005007 Case Report Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane
... basement membrane and proteolysis of the extracellular ...collagen type 1, collagen type 2, and collagen type 3 ...serous membrane like pseudo- mesotheliomatous cancer in the ...
6
Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs
... and metalloproteinase and in a disintegrin and metalloproteinase with thrombospondin) or the transmembrane group as found in membrane-type MMPs [13], and the MMP28 promotor has a unique ...
8
Original Article Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions
... periodontal membrane and alveolar bone are mainly composed of collagenous ...Basement membrane is mainly composed of type IV collagen/gelatin, which can be degrad- ed into small fragments by ...
7
The Cytoplasmic Domain of Membrane-type 1 Matrix Metalloproteinase is Required for its Survival-Promoting, but not its Migration-Promoting Function in MCF-7 Breast Cancer Cells
... This sort of distinct change in cell morphology was observed in this study upon cytoplasmic domain mutation to MT1-MMP, as cells developed protrusive cell extensions in MT1-MMP stable cell lines cultured in a 3D Matrigel ...
100
High threshold of β1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase (MT1-MMP) activation of matrix metalloproteinase 2 (MMP-2)
... MMP-2 activation and fibrillar collagen degradation are thought to be important functions of MT1-MMP. Both of these activities uniquely require MT1-MMP to be in a dimeric form on the cell surface, and inhib- ition of ...
13
mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization
... plasma membrane to induce cancer cell ...performed membrane fractionation ...plasma membrane was significantly ...plasma membrane, confirming that MT1-MMP localization to the plasma ...
15
Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180.
... by matrix metalloproteinases (MMPs), of which, membrane-anchored membrane-type-1 matrix metalloproteinase (MT1-MMP, also known as MMP-14), is a key collagenolysin (Holmbeck et ...
7
Expression of CD147 and matrix metalloproteinase 11 in colorectal cancer and their relationship to clinicopathological features
... extracellular matrix (ECM) and some other ...cellular matrix component, instead, it catalyzes the deg- radation of serine protease inhibitors, a 1-antitrypsin and insulin-like growth factor binding ...
11
Original Article Serum levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 have clinical significance for the evaluation of the prognosis of patients with ruptured intracranial aneurysms after interventional therapy
... Ruptured IA is a common cerebrovascular dis- ease in clinical practice, and SAH accounts for a great percentage of all cases of ruptured IA [10]. Cerebral angiospasm is the most common and severe complication of ruptured ...
7
Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase 2 and NAD(P)H oxidase
... FIG. 1. The effects of OGD±R on the blood-brain barrier integrity and function. Human brain microvascular endothelial cell-human astrocyte co-cultures were exposed to 4 hours of oxygen-glucose deprivation alone (OGD) and ...
33
The effect of tomato juice on the expression of matrix metalloproteinase-2 (MMP-2) and type-1 collagen on the vaginal wall of the menopausal rats
... Increased ROS activates the pathway of the mitogen- activated protein kinase (MAPK) thereby reducing extracellular signal-regulated kinase (ERK) and increasing cJun Kinase (JNK / p38), then activating an increase in ...
6
Serum Matrix Metalloproteinase 3 and Tissue Inhibitor Metalloproteinase 1 in Vascular Dementia: A Comparative Study
... of matrix metalloproteinase 3 (MMP3) and tissue inhibitor metallo- proteinase 1 (TIMP1) in vascular dementia patients and healthy control ...multiinfarct type (VDMI) 14 patients, and vascular ...
7