Membrane-Type Matrix Metalloproteinases
Downregulation of membrane type-matrix metalloproteinases in the inflamed or injured central nervous system
... infiltrating cells at peak AT-EAE in SJL mice to be 34% in CNS isolates [17]. If such infiltrating cells did not express a particular gene which is expressed by endogenous cells in the unmanipulated CNS, then the influx ...
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Matrix metalloproteinases in pancreatitis: current insights
... decomposed type IV collagen of the basement membrane of the pancreatic ducts in ...basement membrane of the pancreas exists between the interstitium and the duct, is mainly composed of type IV ...
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The Significance of Matrix Metalloproteinases in Oral Diseases
... 13]. Matrix metalloproteinases are considered members of the multigene metzincin family, which also includes transmembrane and secreted proteins called a dis- integrin and metalloproteinases (ADAMs), ...
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Matrix metalloproteinases in the wound microenvironment: therapeutic perspectives
... a type II transmembrane domain, whereas the hemopexin-like domain was substituted by a cysteine-rich segment, which forms an immunoglobulin- like ...the membrane-anchored MMPs and three of the secreted MMPs ...
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Matrix metalloproteinases in lung biology
... For matrix sub- strates, integrin–ligand contacts provide an unambiguous signal informing the cell of which protein it has encoun- tered and, hence, which proteinase is needed and to where the enzyme should be ...
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Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma
... Tumor growth, invasion, and metastasis is a multistep process that is facilitated by the proteolytic degradation of components of the extracellular matrix (ECM) and basement membrane. The role of MMPs in ...
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Matrix metalloproteinases in arthritic disease
... the membrane-type matrix metalloproteinase [MT-MMP] MT2- MMP) exclusively present in the rheumatoid ...in type II col- lagen ...of type II collagen in osteoarthritic cartilage seems to ...
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Role of matrix Metalloproteinases in pituitary adenoma invasion
... that type IV collagenases are involved in PA ...distinct membrane structures and found high concentrations of collagen IV in both mem- ...by type IV collagenase, such as MMP-9 and MMP-2, in PA ...
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Matrix metalloproteinases in arthritic disease.
... the membrane-type matrix metalloproteinase [MT-MMP] MT2- MMP) exclusively present in the rheumatoid ...in type II col- lagen ...of type II collagen in osteoarthritic cartilage seems to ...
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MATRIX METALLOPROTEINASES: DO YOU KNOW THEM?
... Matrix Metalloproteinases are expressed in response to specific stimuli by resident connective tissue cells as well as the major inflammatory cell types that invade the tissue during remodeling ...cleave ...
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Original Article Membrane type-2 matrix metalloproteinases improve the progression of renal cell cancer
... Recent studies suggested that MT2-MMP play- ed a significant role in tumor progression, inde- pendent of MT1-MMP, and the TMK-1 cells, which expressed no MT1-MMP but high level of MT2-MMP, still have the ability of ...
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Matrix metalloproteinases in inflammatory bowel disease : expression, regulation and clinical relevance
... KH type splicing regulatory protein (KSFP) proteins increasing or decreasing mRNA stability, respectively, a mechanism shared with TNF-α and other pro-inflammatory ...plasma membrane is dependent on actin ...
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Liver transplantation : chimerism, complications and matrix metalloproteinases
... Donor/recipient mismatches for MMP gene polymorphisms (chapter 7) provided a larger study sample. In this study, MMP gene polymorphisms were solely used as a genetic association marker to explore chimerism and not as a ...
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Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism.
... the membrane- containing fractions from the first gradient was saved for detection of relevant proteins, while the remaining 50% was pooled, adjusted to 80% sucrose and 1 M NaCl, and loaded on the bottom of a ...
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Transforming growth factor-β and abdominal aortic aneurysms
... Elastic fibres in the ECM of vascular tissues provide elasticity and resilience. Elastin is cross-linked and extremely hydrophobic, which makes it one of the most stable proteins in the body [80, 81]. Inflammatory cells ...
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Original Article Association of MMPs/TIMPs polymorphism with alcohol-induced osteonecrosis of femoral head in the Chinese Han population
... the matrix cells andmove the calcium inside out before initiating bone ...bone matrix and trans- port calcium to the zone of calcification at the same ...bone matrix, cause bone matrix ...
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Effect of prostaglandin analogs on matrix metalloproteinases and tissue inhibitor of metalloproteinases in eyelid muscle specimens
... the type of surgery (CMMR vs LAR) and prior use of PA (yes/no) on MMPs and TIMP-2 were analyzed with the two-factor analysis of ...the type of surgery was considered a factor and exposure time to PA was ...
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Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases
... in matrix metalloproteinase (MMP) and decrease in tissue inhibitor of metalloproteinase (TIMP) activity may contribute to the different characteristics observed clinically on decreased intraocular pressure in ...
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Matrix metalloproteinases in head and neck cancer: current perspectives
... neoplasms in general and typical of epithelial malignant neoplasms, local, regional, or metastatic spread depend on a series of interactions and a successful breach of the epithe- lial–mesenchymal interface comprising ...
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ROLE OF MATRIX METALLOPROTEINASES IN THE DEVELOPMENT OF ENDOMETRIOSIS IN WOMEN WITH INFERTILITY
... of matrix metalloproteinases 2, 9 and 11 (MMP-2, MMP-9, MMP-11) was investigated in 20 samples of the endometriotic tissue from women with endometriosis-associated ...of matrix ...
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