memory CD8 T cells
The Impact of a Boosting Immunogen on the Differentiation of Secondary Memory CD8+ T Cells
... of CD8 ⫹ T cells could also be modulated by the help provided by CD4 ⫹ T cells (10, ...rapid CD8 ⫹ T-cell differentiation seen in the DNA-primed mice that oc- curred ...
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Tissue patrol by resident memory CD8+ T cells in human skin
... approach to healthy human skin samples and demonstrate that human CD8 + skin-resident TRM cells.. 87.[r] ...
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NKG2D signaling certifies effector CD8 T cells for memory formation
... in memory CD8 T cells formed upon NKG2D blockade could not be attributed to a quantitative defect (reduced number of memory cells), nor a reduced ability to respond to ...the ...
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Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection
... functional memory CD8 T ...the CD8 T cells early in the response to acute or chronic infection does not simply reflect population dynamics and the selective sur- vival of ...
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Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection
... naïve CD8 T cells in aged mice, responses are dominated by fortuitously cross-reactive memory ...that memory CD8 T cells from influenza-naïve aged mice can respond ...
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Analysis of Apoptosis of Memory T Cells and Dendritic Cells during the Early Stages of Viral Infection or Exposure to Toll-Like Receptor Agonists
... of memory CD8 and CD4 T cells occurs early during many ...to T cell loss rather than ...of T cells ex vivo for activated caspases but with only low levels of ex vivo ...
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Protective Cross-Reactive Cellular Immunity to Lethal A/Goose/Guangdong/1/96-Like H5N1 Influenza Virus Is Correlated with the Proportion of Pulmonary CD8+ T Cells Expressing Gamma Interferon
... Cross-reactive cellular immunity seems to have two impor- tant potential consequences: the protection of hosts from dis- ease and the perpetuation of viruses in these hosts. Some protected chickens shed H5N1 viruses in ...
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CD4+ and CD8+ T cell–dependent antiviral immunity requires STIM1 and STIM2
... ) cells whose primary function is to kill virus-infected cells via the release of granzyme and perforin and the secretion of cytok- ines such as IFN-γ and ...TNF-α. T eff cells are ...
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Role of Thymic Output in Regulating CD8 T-Cell Homeostasis during Acute and Chronic Viral Infection
... the CD8 T-cell defect in Thx mice was not due to incomplete thymectomy, because (i) careful postmortem visual inspection revealed no evidence of thymic remnants in any of the Thx mice and (ii) thymectomy ...
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CD122 signaling in CD8+ memory T cells drives costimulation independent rejection
... on T cell subsets (Figure ...pretransplant memory T cell immunophenotype; how- ever, graft-infiltrating CD8 + T cells in animals that rejected after ...
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Decreased effector memory CD45RA+ CD62L CD8+ T cells and increased central memory CD45RA CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients
... Student’s t-test), between the age of the SLE patient group and the corresponding healthy control group (P > ...Student’s t-test), and between the RA patient group and the SLE patient group (P > ...
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Combined immunization using DNA Sm14 and DNA Hsp65 increases CD8+ memory T cells, reduces chronic pathology and decreases egg viability during Schistosoma mansoniinfection
... of CD8+ T cell activation may explain the low efficacy of the combined vaccination protocol tested, mainly because CD8+ T cells are essential for the eradication of intracellular ...
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RNA Interference Inhibits Respiratory Syncytial Virus Replication and Disease Pathogenesis without Inhibiting Priming of the Memory Immune Response
... the memory T-cell or antibody response to RSV ...the memory T- cell response was robust in WT siRNA-treated ...and CD8 ⫹ T cells make significant independent contributions ...
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Human Immunodeficiency Virus-Specific Circulating CD8 T Lymphocytes Have Down-Modulated CD3ζ and CD28, Key Signaling Molecules for T-Cell Activation
... antiviral CD8 T-cell compartment may also be true of the HIV response of CD4 T ...CD4 T cells are absent in most HIV-infected individ- ...CD4 memory cells that produce ...
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The interplay between immune maturation, age, chronic viral infection and environment
... and CD8 + T cell responses to the HCMV proteome in 32 healthy long-term HCMV- infected individuals ...of memory CD4 + and CD8 + T cells are specific to HCMV antigens, far ...
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Signatures of immune reprogramming in anti-CD52 therapy of MS: markers for risk stratification and treatment response
... of T cell subsets (CD4 and CD8 positive T cells: naïve T cells, T effector cells, T memory cells, regulatory T cells; ...
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Persistence of Transgene Expression Influences CD8+ T-Cell Expansion and Maintenance following Immunization with Recombinant Adenovirus
... the CD8 ⫹ T-cell expansion phase to sustain the memory population may reflect a situation where naïve T cells are continuously recruited into the memory population to replace ...
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Cognate CD4 T-Cell Licensing of Dendritic Cells Heralds Anti-Cytomegalovirus CD8 T-Cell Immunity after Human Allogeneic Umbilical Cord Blood Transplantation
... by T lym- phocytes. In particular, CD8 ⫹ cytotoxic T lymphocytes (CTLs) fulfill a predominant role in protection against CMV disease (2– ...immunological memory against, ...⫹ T-cell ...
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MCL1 Enhances the Survival of CD8+ Memory T Cells after Viral Infection
... antigen-specific CD8 ⫹ T cells were equivalent in nontransgenic and transgenic animals at 10 days, in transgenic animals, a lower proportion of these cells expressed annexin V, a marker that ...
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Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
... CMV-specific T cell clones were stimulated with anti-CD3 and anti-CD28 mAbs, human γ-irradiated PBMCs and B-lymphoblastoid lymphocytes, and IL-2 (50 U/ml), as previously described (48, ...2, cells were ...
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