Memory T cell
Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy
... of memory T cell– derived cells (T Mem cells) (11, ...that T N -derived cells maintain higher levels of the costimulatory marker CD27 and the lymphoid homing mark- ers CD62L and CCR7; ...
18
Mucosal BCG Vaccination Induces Protective Lung Resident Memory T Cell Populations against Tuberculosis
... of memory T cells has been shown to be essential for protective TB ...lung-resident memory T cell populations that confer protection against pulmonary ...
11
A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool
... To allow statistical analysis of the magnitude of clonal dis- parity between different combinations of cell compartments, an additional measurement of disparity was established (applied in Figs. 3 C and 7 F). ...
22
The LCMV gp33-specific memory T cell repertoire narrows with age
... There are many reports concerning TCE in both mice and humans [15-20,22,23,33,34]. There is no clear con- sensus concerning the genesis of TCE except the expan- sions are not malignant cells and are not associated with ...
9
Regulation of human naive and memory T cell populations by apoptosis and replicative senescence
... CD8^ T Lymphocytes During EBV Infection 119 In addition, the EBV-lytic epitope specific CD45RA^ T ceils from chronic patients were able to re-express CD45RO upon re activation with specific ...This ...
194
Inflammatory IL 15 is required for optimal memory T cell responses
... model avoids the complication of the role of IL-15 in trafficking to inflamed tissues (11, 37). Therefore, we asked whether the inabil- ity to sense IL-15 following viral infection would affect patho- gen control in the ...
15
KLRG1 restricts memory T cell antitumor immunity
... RosetteSep enrichment cocktail following with Ficoll density gradient. Human T cells were cultured in RPMI 1640 with 10% FBS and 1% penicillin/streptomycin. Human tissues of colon cancer (n = 10), colitis (n = ...
9
CD8<sup>+</sup> memory T-cell inflation renders compromised CD4<sup>+</sup> T-cell-dependent CD8<sup>+</sup> T-cell immunity via naïve T-cell anergy
... and tibiae of WT B6 mice were depleted of red-blood cells with 0.84% ammonium chloride and plated in DC culture medium (Dulbecco’s Modified Eagle’s Medium plus 10% fetal calf serum, GM-CSF [20 ng/mL] and IL4 [20 ng/mL]). ...
11
Increased attrition of memory T cells during sepsis requires 2B4
... generate T cell memory before sepsis induction (48, ...anti-CD3–mediated T cell activation and memory T cell generation demonstrat- ed increased immune ...
12
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
... in memory T cell and Teff formation, such as Tcf7, Lef1, Bcl6, and Prdm1, as well as T cell differentiation markers, includ- ing CD44, CD62L, CD27, and ...2DG-treated T cells ...
11
Human CD8+ and CD4+ T Cell Memory to Lymphocytic Choriomeningitis Virus Infection
... the T cell response to this virus in humans is incompletely ...of memory LCMV- specific CD8 ⴙ and CD4 ⴙ T cells in three human donors displaying a variety of disease outcomes after accidental ...
11
Virus-Specific CD4+ and CD8+ Cytotoxic T-Cell Responses and Long-Term T-Cell Memory in Individuals Vaccinated against Polio
... PV-specific memory T cells. As DCs can stimulate both primary and secondary T-cell re- sponses, it was unclear whether the PV-specific cells stimulated by DCs were recall responses from the ...
8
AMPKα1: A glucose sensor that controls CD8 T cell memory
... of memory cell forma- tion is a strong activator of mTORC1 signaling whereas IL-15, which supports memory T-cell formation, only weakly initiates mTORC1 activity ...trast, memory ...
8
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
... antigen-specific T cells that have been expanded ex vivo is being actively pursued to treat infections and malignancy in ...The T cell populations that are available for adoptive immunotherapy ...
13
Inducible nitric oxide synthase in T cells regulates T cell death and immune memory
... If T cell death by neglect, a consequence of the withdrawal of trophic signals due to antigen clearance, is the only death pathway operative in normal immune responses, T cell memory ...
10
Differences in coreceptor specificity contribute to alternative tropism of HIV 1 subtype C for CD4+T cell subsets, including stem cell memory T cells
... Although HIV-1 subtype C (C-HIV) strains account for >50% of HIV-1 infections worldwide and exhibit pathogenicity and tropism alterations that are distinct from other HIV-1 subtypes [12], at present there are few ...
6
Reduced thymus activity and infection prematurely age the immune system
... slowly. T cell counts and T cell function remain high, and there is no dramatic shift in the high naive/memory T cell ratio over ...naive T cells is the most common ...
5
T cell co stimulatory pathways in autoimmunity
... naïve T-cell responses more than effector T cells ...disabling T cells with CTLA4-Ig in nonimmune patients is not known at present, but it is possible that host defenses are ...deficient. ...
10
Impaired CD4 T Cell Memory Response to Streptococcus pneumoniae Precedes CD4 T Cell Depletion in HIV-Infected Malawian Adults
... specific T cells when compared with immunity to ...generalized memory T cell depletion, including mucosal compartmentaliza- tion of pneumococcal-specific T cell depletion and HIV ...
10
Human cytotoxic T-cell memory: long-lived responses to vaccinia virus.
... specific T-cell memory? One mechanism that has been suggested is immunological cross- reactivity between viruses (2, 21, ...cross-reactive T-cell re- sponses in mouse models and ...
5