meningococcal sepsis
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
... in sepsis [37]. High levels of TNF in the initial phase of sepsis have been associated with early hemodynamic deterioration [37, ...of sepsis development may be particularly ...of sepsis ...
9
Validation of a method to partition the base deficit in meningococcal sepsis: a retrospective study
... with meningococcal sepsis admitted to the paediatric intensive care unit from January 2001 to June ...with meningococcal meningitis without septic shock were ...
7
Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis
... a meningococcal infection admitted to the PICU, as well as for 46 age- and sex-matched healthy controls (Table 1; see Table S1 in the supplemental ...with meningococcal sepsis and of their ...
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Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis
... Data analysis. The absolute intensities of the extracted glycoforms were total area normalized per IgG subclass, and derived glycan traits were calculated based on specific glycosylation features (Table 2 and Table S2). ...
13
CC and CXC chemokine levels in children with meningococcal sepsis accurately predict mortality and disease severity
... in meningococcal sepsis or septic shock has not so far been studied ...In meningococcal disease, lipo-oligosaccharide and outer mem- brane proteins of the meningococcus induce a strong inflam- matory ...
8
The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults.
... The priority for patients admitted with suspected meningi- tis is to a) stabilise their airway, breathing and circulation, b) begin appropriate investigations, and c) instigate prompt treatment. These three things should ...
34
A new scoring system derived from base excess and platelet count at presentation predicts mortality in paediatric meningococcal sepsis
... in meningococcal sepsis, target- ing pathways of inflammation and coagulation such as recombinant bactericidal/permeability-increasing protein (rBPI) [4] and human activated protein C (rhAPC) [5], have ...
11
Pathophysiological aspects of hyperglycemia in children with meningococcal sepsis and septic shock: a prospective, observational cohort study
... Better insight into pathophysiological mechanisms leading to hyperglycemia is crucial to improve treatment strategies. The gold standard for quantifying insulin sen- sitivity in vivo is the hyperinsulinemic euglycemic ...
10
Bench to bedside review: Genetic influences on meningococcal disease
... of meningococcal disease, which is in contrast with the association of high TNF levels and the adverse outcome shown by other studies ...in meningococcal sepsis is unclear ...during ...
6
Chronic Meningococcemia
... of meningococcal disease, globally, accounting for 80% to 85% of all reported cases, is Meningococcal meningitis (in half of these cases sepsis is also present ...a meningococcal sepsis ...
5
Improving Early Sepsis Identification on Inpatient Units
... of sepsis identification and treatment provided grounds for improving resource materials for these ...with sepsis to ultimately lead to better outcomes for both the hospital and its ...
34
Prevention and Control of Meningococcal Disease: Recommendations for Use of Meningococcal Vaccines in Pediatric Patients
... of meningococcal disease relative to other people their ...of meningococcal disease and potential benefits of im- munization with MPSV4, that college and university health services facilitate implementation ...
12
Evaluation of the surveillance system for invasive meningococcal disease (IMD) in the Netherlands, 2004–2016
... Abbreviations CSF: Cerebrospinal fluid; IMD: Invasive meningococcal disease; IMDW: Invasive meningococcal disease caused by serogroup W; IQR: Interquartile range; NRLBM: Netherlands Refe[r] ...
8
UK parents’ attitudes towards meningococcal group B (MenB) vaccination: a qualitative analysis
... how meningococcal infec- tion spreads, its incidence and who is most likely to catch it (quote 2, table ...of meningococcal disease were either medically trained or had paid privately for their children to ...
10
Acute polyarthritis in a young patient caused by meningococcal and parvovirus B19 infections: a case report and review of the literature
... adults and children from 1977 to 2015 (Table 1). Diag- noses were made by positive blood culture or positive joint fluid culture. Among them, one case that only in- cluded a positive pharyngeal swab test was considered ...
5
Sepsis-3 definitions predict ICU mortality in a low–middle-income country
... new sepsis definitions raised several concerns [26, 27], and the Surviving Sepsis Campaign suggested that lactate should continue to be measured to identify dysfunction ...of Sepsis-3 definitions, ...
9
The Hypervariable Region of Meningococcal Major Pilin PilE Controls the Host Cell Response via Antigenic Variation
... The major pilin subunit PilE is involved in host cell responses. As mentioned above, a pilV-mutated strain is unable to signal to endothelial cells, thus demonstrating the essential role of PilV to induce a host cell ...
13
Development and Evaluation of a Tetraplex Flow Cytometric Assay for Quantitation of Serum Antibodies to Neisseria meningitidis Serogroups A, C, Y, and W-135
... Microsphere assay for quantification of meningococcal serogroup capsular polysaccharide-specific IgG. Seven fourfold dilutions (1:20 to 1:81,920) of stan- dard reference serum sample CDC 1992 were prepared in PBS ...
8
A Study on the Validation of paediatric index of mortality 2 (PIM2) score in the Paediatric Intensive Care Unit of CMC, Vellore
... predominantly sepsis as major cause of admission, malnutrition, chronic illness, delayed referral, absence of good transport facilities for sicker children, scarce resources, both physical and human staffing of ...
78
Meningococcal pneumonia: a review
... of meningococcal pneumonia, either on its own, or associated with other forms of meningococcal infection ...primary meningococcal pneumonia reported in the US, ser- ogroup Y infection was documented ...
13