Merkel cell polyomavirus
Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus Associated Merkel Cell Carcinoma
... the cell, which has important implications for treatment and the evo- lution rate of the ...of Merkel cell polyomavirus to hijack specific cellular processes and produce a tumorigenic pheno- ...
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Novel human polyomaviruses, Merkel cell polyomavirus and human polyomavirus 9, in Japanese chronic lymphocytic leukemia cases
... between Merkel cell polyomavirus (MCPyV) and CLL, although no data have been reported from Eastern ...human polyomavirus 9 (HPyV9), another lymphotropic polyomavirus, in Japanese CLL ...
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The T Antigen Locus of Merkel Cell Polyomavirus Downregulates Human Toll-Like Receptor 9 Expression
... virus, Merkel cell polyomavirus (MCPyV), has been recently identified that causes up to 80% of Merkel cell carcinomas ...BK polyomavirus (BKPyV), JC polyomavirus (JCPyV), ...
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Age-Specific Seroprevalence of Merkel Cell Polyomavirus, BK Virus, and JC Virus
... of Merkel cell polyomavirus, a recently discovered human polyomavirus implicated in the eti- ology of Merkel cell cancer, and compared its seroprevalence to those of the first ...
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Merkel Cell Polyomavirus Small T Antigen Drives Cell Motility via Rho-GTPase-Induced Filopodium Formation
... ABSTRACT Cell motility and migration is a complex, multistep, and multicompo- nent process intrinsic to progression and ...sions. Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high ...
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Merkel Cell Polyomavirus-Infected Merkel Cell Carcinoma Cells Require Expression of Viral T Antigens
... Merkel cell carcinoma (MCC) is the most aggressive skin ...human Merkel cell polyomavirus (MCV) is clonally integrated in ⬃ 80% of MCC ...MCC cell lines using three different ...
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Ganglioside GT1b Is a Putative Host Cell Receptor for the Merkel Cell Polyomavirus
... The Merkel cell polyomavirus (MCPyV) was identified recently in human Merkel cell carcinomas, an aggressive neuroendocrine skin ...host cell receptor for ...host cell ...
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Assessing host virus codivergence for close relatives of Merkel cell polyomavirus infecting African great apes
... lineage of PyV infecting hominine hosts, the Merkel cell polyomavirus MCPyV lineage.. characterizing their genetic diversity in seven African great ape taxa, we show that these.[r] ...
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Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review
... Abstract: Merkel Cell Polyomavirus (MCV) is a virus belonging to the human Polyomavirus ...of Merkel Cell Carcinoma (MCC) tumors, it has been associated with this rare and ...
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Detection of Merkel cell polyomavirus in cervical squamous cell carcinomas and adenocarcinomas from Japanese patients
... Background: Merkel cell polyomavirus (MCPyV) was identified originally in Merkel cell carcinoma (MCC), a rare form of human skin neuroendocrine ...squamous cell carcinomas (SCCs) ...
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Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus.
... is Merkel cell carcinoma (MCC), a rare but aggressive skin ...2008, Merkel cell polyomavirus (MCPyV) was discovered as the causative agent of ...oncogenic polyomavirus, and open ...
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The Minimum Replication Origin of Merkel Cell Polyomavirus Has a Unique Large T-Antigen Loading Architecture and Requires Small T-Antigen Expression for Optimal Replication
... Merkel cell polyomavirus (MCV) is a recently discovered human polyomavirus causing the majority of human Merkel cell carcinomas. We mapped a 71-bp minimal MCV replication core ...
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Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen
... Merkel cell polyomavirus (MCV) is a newly discovered human cancer virus encoding a small T (sT) ...for Merkel cell carcinoma growth, but its in vitro transforming activity depends on ...
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African Great Apes Are Naturally Infected with Polyomaviruses Closely Related to Merkel Cell Polyomavirus
... oncogenic Merkel cell polyomavirus (MCPyV) infects humans worldwide, but little is known about the occurrence of viruses related to MCPyV in the closest phylogenetic relatives of humans, great ...
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Merkel Cell Polyomavirus Large T Antigen Disrupts Host Genomic Integrity and Inhibits Cellular Proliferation
... of Merkel cell polyomavirus (MCV) DNA into the host genome has been observed in at least 80% of Merkel cell carcinoma ...and cell cycle ...
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Merkel Cell Polyomavirus Infection of Animal Dermal Fibroblasts
... ABSTRACT Merkel cell polyomavirus (MCPyV) is the first polyomavirus to be associ- ated with human ...during Merkel cell carcinoma (MCC) oncogenic ...
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The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA Replication
... Merkel cell polyomavirus (MCPyV) plays an important role in Merkel cell carcinoma (MCC). MCPyV small T (sT) antigen has emerged as the key oncogenic driver in MCC carcinogenesis. It has ...
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Age-Specific Seroprevalences of Merkel Cell Polyomavirus, Human Polyomaviruses 6, 7, and 9, and Trichodysplasia Spinulosa-Associated Polyomavirus
... (Merkel cell polyomavirus [MCPyV], human polyomavirus 6 [HPyV6], HPyV7, HPyV9, trichodysplasia spinulosa polyomavirus [TSPyV], and Malawi polyomavirus ...
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A new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV)
... Tolstov Y, Gjoerup O, Mansukhani MM, Swerdlow SH, Chaudhary PM, Kirkwood JM, Nalesnik MA, Kant JA, Weiss LM, Moore PS, Chang Y: Human Merkel cell polyomavirus infection I. MCV T antigen expression in ...
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Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E BP1 translation regulator
... Merkel cell polyomavirus (MCV) is the recently discovered cause of most Merkel cell carcinomas (MCCs), an aggressive form of nonmelanoma skin ...tumor cell genome and to undergo ...
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