Merozoite surface protein
Genetic polymorphism of merozoite surface protein 2 and prevalence of K76T pfcrt mutation in Plasmodium falciparum field isolates from Congolese children with asymptomatic infections
... Genotyping of merozoite surface protein-2 (msp2) is the commonly used method to study the genetic diversity of P. falciparum. This gene presents polymorphisms in the number of repeats and sequence ...
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Asymptomatic Plasmodium falciparum infection in children is associated with increased auto antibody production, high IL 10 plasma levels and antibodies to merozoite surface protein 3
... a protein micro-array immunoassay, the total auto-antibody repertoire by quantitative immunoblotting and circulating cytokine levels were measured by ELISA in endemic controls (EC) and ...to merozoite ...
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Antibody responses to the merozoite surface protein 1 complex in cerebral malaria patients in India
... The merozoite surface protein (MSP)-1, a large multipro- tein complex exposed on the surface of merozoites, is one of the well characterized antigens of ...
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Identification and characterization of Pv50, a novel Plasmodium vivax merozoite surface protein
... and merozoite surface proteins in native ...with merozoite surface protein(s), fluorescence intensi- ties observed using the Cy5 channel from the simulta- neous activity and binding ...
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Immunogenicity of a chimeric Plasmodium falciparum merozoite surface protein vaccine in Aotus monkeys
... There is mounting agreement in the field that an effec- tive malaria vaccine will require induction of immune responses to multiple, distinct target antigens. This con- cept is central in the development of whole ...
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Polymorphic patterns of the merozoite surface protein 3β in Korean isolates of Plasmodium vivax
... The P. vivax merozoite surface protein-3 (PvMSP-3) family consists of several related proteins, PvMSP-3α, PvMSP-3β and PvMSP-3γ. Although the level of shared amino acid sequence identity among the ...
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Characterization of Pv92, a novel merozoite surface protein of Plasmodium vivax
... a merozoite surface protein, and this protein is ex- pressed at the late schizont stage, but no study of Pv92, the orthologue of Pf92 in ...the protein structure of Pv92 was analyzed, ...
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Changing pattern of the genetic diversities of Plasmodium falciparum merozoite surface protein 1 and merozoite surface protein 2 in Myanmar isolates
... falciparum merozoite surface protein-1 (PfMSP-1) and -2 (PfMSP-2) are major blood-stage vaccine candidate antigens, which play important roles in erythrocyte inva- sion [6, 7], and are targeted by ...
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IMMUNOGENICITY OF THE MEROZOITE SURFACE PROTEIN-1 (MSP-1) OF HUMAN PLASMODIUM SP.
... the merozoite surface protein-1 (MSP-1), specifically on its evaluation and immunogenicity in rodents and primate models, and its safety and immunogenicity in human clinical ...
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Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non polymorphic domains
... Figure 1 Schematic structure, full-length alignment sequence, and overlapping 20 mers covering D and C regions of MSP2. A) Represents schematic structures of merozoite surface protein 2 (MSP2) with ...
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Diversity and population structure of Plasmodium falciparum in Thailand based on the spatial and temporal haplotype patterns of the C terminal 19 kDa domain of merozoite surface protein 1
... Additional file 2: Nucleotide sequence alignment of the Plasmodium falciparum merozoite surface protein-1 (msp-1) gene block 17. Data shows the representative five variants (haplotypes E/KNG/L, ...
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Merozoite surface protein 3α is a reliable marker for population genetic analysis of Plasmodium vivax
... Table 1: PCR-RFLP analysis of msp-3 α gene in 50 northern and 94 southern P. vivax clinical isolates from Iran. B = Belem Type 1; S = Salvador I Type 2; R = Recombinant Type 3 [20]. N = northern sample, S = southern ...
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Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein 1 (MSP142) administered intramuscularly with adjuvant system AS01
... recombinant protein Plasmodium falciparum vaccine antigens which, when mixed with po- tent adjuvants such as AS01, an Adjuvant System con- taining 3-O-desacyl-4’-monophosphoryl lipid A (MPL) and Quillaja saponaria ...
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Genetic diversity of the merozoite surface protein 3 gene in Plasmodium falciparum populations in Thailand
... accumulating. First, hyperimmune sera that inhibited P. falciparum growth in vitro in the presence of blood monocytes in an antibody-dependent cellular assay were shown to contain antibodies targeting MSP-3 [12, 13]. ...
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Immunogenicity analysis of genetically conserved segments in Plasmodium ovale merozoite surface protein 8
... Parasite antigenic diversity has become a major obsta- cle hindering the development of effective malaria vac- cines [14]. Erythrocyte invasion is a critical point in the life-cycle of malaria parasites and it is at this ...
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Merozoite surface protein-7. A novel protein on the surface of Plasmodium falciparum merozoites
... the surface o f the parasite as a precursor for the formation o f individual ...f merozoite formation develop at the ends o f each mitotic spindle, these are spaced at regular intervals in the ...
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Effect of malaria transmission reduction by insecticide treated bed nets (ITNs) on the genetic diversity of Plasmodium falciparum merozoite surface protein (MSP 1) and circumsporozoite (CSP) in western Kenya
... and the highly polymorphic pre-erythrocytic-stage circum- sporozoite protein (CSP) Th2R and Th3R T-helper cell epitopes. These two genes were chosen for assessment because their polymorphism is thought to be ...
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Genetic polymorphism of merozoite surface protein 1 and merozoite surface protein 2 in Plasmodium falciparum field isolates from Myanmar
... population [36]. Multiple clonal infections with different genotypes of P. falciparum were identified among Myan- mar P. falciparum isolates in a high proportion (79.4% for MSP-1 and 87.3% for MSP-2). And a high level of ...
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Genetic polymorphism of merozoite surface protein 1 and merozoite surface protein 2 in Plasmodium falciparum isolates from Brazzaville, Republic of Congo
... The present study was aimed at analysing genetic diversity of Plasmodium falciparum merozoite surface proteins 1 and 2 MSP-1 and MSP-2 and to determine the multiplicity of infection in c[r] ...
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Plasmodium falciparum merozoite surface protein 1: Antigenicity, immunogenicity and structure.
... fusion protein and tested as to whether or not they can act synergistically to block parasite ...fusion protein o f Pfs25 and Pfs28 can induce potent transmission-blocking antibodies in mice (Gozar et al, ...
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