Mesenchymal Stromal Cells (MSC)
Umbilical cord as a long-term source of activatable mesenchymal stromal cells for immunomodulation
... Mesenchymal stromal cells (MSCs) are used in a variety of clinical trials for a plethora of diseases, due to therapeutic- ally relevant characteristics such as their differentiation po- tential, ...
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Immunoresponse to Allogeneic Synovial or Xenogenic Mesenchymal Stromal Cells in a Co Culture Model
... genic cells, selected as potential sources for cell therapy of ...spleen-derived cells (hSpl) by three different mechanisms: 1) exposure to donor allogeneic or xenogeneic cellular antigens; 2) exposure to ...
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Immunoresponse to Allogeneic Synovial or Xenogenic Mesenchymal Stromal Cells in a Co Culture Model
... genic cells, selected as potential sources for cell therapy of ...spleen-derived cells (hSpl) by three different mechanisms: 1) exposure to donor allogeneic or xenogeneic cellular antigens; 2) exposure to ...
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Generation of mesenchymal stromal cells from cord blood: evaluation of in vitro quality parameters prior to clinical use
... of mesenchymal stromal cells (MSC) as advanced therapy medicinal products because of their immunomodulatory properties and supportive role in ...off-the-shelf MSC, cord blood (CB) ...
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The effect of thymic mesenchymal stromal cells on arginase activity and nitric oxide produced by mouse macrophages
... Mesenchymal stromal cells (MSC) gained much attention due to their therapeutic properties, media- ted largely by anti-inflammatory ...of MSC obtained from young mice to modulate ...
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Human cord blood-derived platelet lysate enhances the therapeutic activity of adipose-derived mesenchymal stromal cells isolated from Crohn’s disease patients in a mouse model of colitis
... Mesenchymal stromal cells (MSCs) are multipotent adult stem cells [1] which can differentiate in vitro and in vivo into several tissue lineages originating from the three ger- minal layers [2, ...
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Decellularized silk fibroin scaffold primed with adipose mesenchymal stromal cells improves wound healing in diabetic mice
... adipose mesenchymal stromal cells; Ad-MSCs- SF: silk fibroin patch cellularized with human adipose-derived mesenchymal stromal cells; ADM: adipocyte differentiation medium; CB: ...
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Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease
... tissue-derived mesenchymal stromal cells (ASCs) Canine low passage (P2-P5) ASCs from 5 dogs were ob- tained from falciform fat collected from UCD William ...
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Study the Safety and Efficacy of Mesenchymal Stromal Cells (MSC) in the treatment of Recurrent High Fistula-in-ano: A Pilot study
... These mesenchymal stromal cells are isolated after extraction from the bone marrow aspirate of the donor after removal of the other cell lines and expanded in ...These cells maintain the ...
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Are mesenchymal stromal cells immune cells?
... that MSC therapy lowered C-reactive protein levels, but did not affect disease indicators ...of MSC immunotherapy remains to be dem- onstrated in larger placebo-controlled trials, in several of the studies ...
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Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds
... equine MSC CM causes membrane depolarization of ...equine MSC CM-mediated bacterial membrane damage resulted in similar immediate killing of ...equine MSC CM did not immediately kill bacteria to the ...
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Clinical scale expansion of mesenchymal stromal cells: a large banking experience
... use. MSC produced and used in our clini- cal trials are of allogeneic origin but do not seem to elicit immune ...HLA-mismatched MSC manufactured by the same process were shown to be weakly immunogenic after ...
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Autologous mesenchymal stromal cells embedded in tricalcium phosphate for posterolateral spinal fusion: results of a prospective phase I/II clinical trial with long-term follow-up
... of MSC, expanded in a GMP facility, and released according to the International Society for Cellular Therapy (ISCT) criteria ...of MSC with tricalcium phosphate (TCP) and their preclinical evaluation in a ...
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Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process
... marrow MSC are sensitive to very low levels of radiation and trigger senescence due to impaired autophagy and DNA repair ...Apoptotic cells are quickly cleared by phagocytes and may be replaced by new ...
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Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death
... T cells, macrophages and alveolar type II epithelial ...iNKT cells to amplify IL-17 production to mediate lung IR injury ...immune cells responsible for initiat- ing lung IR injury remain ...
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Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
... these cells in unstable plaques com- pared to those from patients with stable coronary ar- tery disease [3, ...of mesenchymal stromal cells (MSCs) showed promise in preclinical studies and ...
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Perinatal sources of mesenchymal stem cells: Wharton’s jelly, amnion and chorion
... the cells present in the amniotic ...adherent cells isolated from the amniotic fluid without division into E-type, AF-type and F-type ...adherent cells obtained from the amniotic fluid (AF-type) ...
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Cryopreservation of canine cardiosphere-derived cells: Implications for clinical application
... canine cells the present study also provides vital translational information to the human ...fresh cells is similar to reports in other species (21,31), conversely the large spheres from cryopreserved ...
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Chondrogenic induction of mesenchymal stromal/stem cells from Wharton’s jelly embedded in alginate hydrogel and without added growth factor: an alternative stem cell source for cartilage tissue engineering
... WJ- MSC viability (>80 %) at day 14 which was maintained until the end of the ...necrotic cells found at day 3 seemed to be due to the spraying method, and were eliminated in the last step of necro- ...
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Phenotypic change and induction of cytokeratin expression during in vitro culture of corneal stromal cells
... Western. Cells were seeded in 24-well glass-bottom plates (Greiner Bio- One, Gloucestershire, UK) and cultured until confluence; or, for quiescent CSC, 21 days to allow for ...conjugated; cells were ...
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